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• W4313491471 endingPage "111952" @default.
• W4313491471 startingPage "111952" @default.
• W4313491471 abstract "Sensory processing is crucial for execution of appropriate behavior. The external globus pallidus (GPe), a nucleus within the basal ganglia, is highly involved in the control of movement and could potentially integrate sensory-motor information. The GPe comprises prototypic and arkypallidal cells, which receive partially overlapping inputs. It is unclear, however, which inputs convey sensory information to them. Here, we used in vivo whole-cell recordings in the mouse GPe and optogenetic silencing to characterize the pathways that shape the response to whisker stimulation in prototypic and arkypallidal cells. Our results show that sensory integration in prototypic cells is controlled by the subthalamic nucleus and indirect pathway medium spiny neurons (MSNs), whereas in arkypallidal cells, it is primarily shaped by direct pathway MSNs. These results suggest that GPe subpopulations receive sensory information from largely different neural populations, reinforcing that the GPe consists of two parallel pathways, which differ anatomically and functionally." @default.
• W4313491471 created "2023-01-06" @default.
• W4313491471 creator A5013467876 @default.
• W4313491471 creator A5058669809 @default.
• W4313491471 date "2023-01-01" @default.
• W4313491471 modified "2023-09-30" @default.
• W4313491471 title "Sensory processing in external globus pallidus neurons" @default.
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• W4313491471 doi "https://doi.org/10.1016/j.celrep.2022.111952" @default.
• W4313491471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640317" @default.
• W4313491471 hasPublicationYear "2023" @default.
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