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- W4313491524 abstract "Neuronal hyperactivity induces memory deficits in Alzheimer’s disease. However, how hyperactivity disrupts memory is unclear. Using in vivo synaptic imaging in the mouse visual cortex, we show that structural excitatory-inhibitory synapse imbalance in the apical dendrites favors hyperactivity in early amyloidosis. Consistent with this, natural images elicit neuronal hyperactivity in these mice. Compensatory changes that maintain activity homeostasis disrupt functional connectivity and increase population sparseness such that a small fraction of neurons dominates population activity. These properties reduce the selectivity of neural response to natural images and render visual recognition memory vulnerable to interference. Deprivation of non-specific visual experiences improves the neural representation and behavioral expression of visual familiarity. In contrast, in non-pathological conditions, deprivation of non-specific visual experiences induces disinhibition, increases excitability, and disrupts visual familiarity. We show that disrupted familiarity occurs when the fraction of high-responsive neurons and the persistence of neural representation of a memory-associated stimulus are not constrained." @default.
- W4313491524 created "2023-01-06" @default.
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- W4313491524 date "2023-01-01" @default.
- W4313491524 modified "2023-10-15" @default.
- W4313491524 title "Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions" @default.
- W4313491524 cites W1580065819 @default.
- W4313491524 cites W1584834830 @default.
- W4313491524 cites W1646796606 @default.
- W4313491524 cites W1927567505 @default.
- W4313491524 cites W1967917932 @default.
- W4313491524 cites W1973253072 @default.
- W4313491524 cites W1979344173 @default.
- W4313491524 cites W1979612107 @default.
- W4313491524 cites W1984881525 @default.
- W4313491524 cites W1990752558 @default.
- W4313491524 cites W2004852048 @default.
- W4313491524 cites W2015393008 @default.
- W4313491524 cites W2015701831 @default.
- W4313491524 cites W2017539895 @default.
- W4313491524 cites W2036550078 @default.
- W4313491524 cites W2039881289 @default.
- W4313491524 cites W2039894149 @default.
- W4313491524 cites W2040709031 @default.
- W4313491524 cites W2048685634 @default.
- W4313491524 cites W2052364473 @default.
- W4313491524 cites W2054578267 @default.
- W4313491524 cites W2056431599 @default.
- W4313491524 cites W2062605351 @default.
- W4313491524 cites W2071529764 @default.
- W4313491524 cites W2074376560 @default.
- W4313491524 cites W2078459727 @default.
- W4313491524 cites W2078917784 @default.
- W4313491524 cites W2082429191 @default.
- W4313491524 cites W2086664483 @default.
- W4313491524 cites W2103775384 @default.
- W4313491524 cites W2116529502 @default.
- W4313491524 cites W2118516203 @default.
- W4313491524 cites W2124733101 @default.
- W4313491524 cites W2134494361 @default.
- W4313491524 cites W2146008734 @default.
- W4313491524 cites W2167279371 @default.
- W4313491524 cites W2168312889 @default.
- W4313491524 cites W2168334242 @default.
- W4313491524 cites W2287764147 @default.
- W4313491524 cites W2292595116 @default.
- W4313491524 cites W2305929847 @default.
- W4313491524 cites W2314634699 @default.
- W4313491524 cites W2336146895 @default.
- W4313491524 cites W2461575795 @default.
- W4313491524 cites W2472130460 @default.
- W4313491524 cites W2474977510 @default.
- W4313491524 cites W2519528771 @default.
- W4313491524 cites W2538812158 @default.
- W4313491524 cites W2543770555 @default.
- W4313491524 cites W2549366107 @default.
- W4313491524 cites W2617018884 @default.
- W4313491524 cites W2735697144 @default.
- W4313491524 cites W2761818916 @default.
- W4313491524 cites W2767500419 @default.
- W4313491524 cites W2782493947 @default.
- W4313491524 cites W2785094520 @default.
- W4313491524 cites W2790477621 @default.
- W4313491524 cites W2790954104 @default.
- W4313491524 cites W2791212118 @default.
- W4313491524 cites W2797445080 @default.
- W4313491524 cites W2799622464 @default.
- W4313491524 cites W2820472930 @default.
- W4313491524 cites W2883065428 @default.
- W4313491524 cites W2902439423 @default.
- W4313491524 cites W2904140944 @default.
- W4313491524 cites W2910040357 @default.
- W4313491524 cites W2950893325 @default.
- W4313491524 cites W2952117376 @default.
- W4313491524 cites W2965194014 @default.
- W4313491524 cites W2968840243 @default.
- W4313491524 cites W2969899571 @default.
- W4313491524 cites W2980485312 @default.
- W4313491524 cites W2991298252 @default.
- W4313491524 cites W2994737554 @default.
- W4313491524 cites W3000353894 @default.
- W4313491524 cites W3011830677 @default.
- W4313491524 cites W3033511372 @default.
- W4313491524 cites W3035710767 @default.
- W4313491524 cites W3042751831 @default.
- W4313491524 cites W3084726996 @default.
- W4313491524 cites W3088306168 @default.
- W4313491524 cites W3093342946 @default.
- W4313491524 cites W3112777140 @default.