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- W4313491644 endingPage "100421" @default.
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- W4313491644 abstract "Kojic acid-aromatic aldehydes 6a-6m were synthesized and screened for their anti-tyrosinase activities. These compounds showed potently anti-tyrosinase activity with IC50 values in the range of 5.32 ± 0.23 to 77.89 ± 3.36 μM compared with kojic acid (IC50 = 48.05 ± 3.28 μM). Thereinto, compound 6j with 3-fluorine and 4-aldehyde substitutions showed the most potent anti-tyrosinase activity (IC50 = 5.32 ± 0.23 μM). Enzyme kinetic study revealed that 6j is a noncompetitive tyrosinase inhibitor (Ki = 2.73 μM). The action mechanism of 6j was evaluated by fluorescence spectrum quenching, molecular docking, 1H NMR titration, etc. The anti-browning assay showed that 6j could delay the enzymatic browning of fresh-cut apples. Besides, the cell viability assay proved that 6j had a good safety profile as an anti-browning agent. Hence, these results identify a new class of anti-tyrosinase and anti-browning agents for further investigation in the food industry." @default.
- W4313491644 created "2023-01-06" @default.
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- W4313491644 date "2023-01-01" @default.
- W4313491644 modified "2023-10-14" @default.
- W4313491644 title "Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety" @default.
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- W4313491644 doi "https://doi.org/10.1016/j.crfs.2022.100421" @default.
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