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- W4313492708 endingPage "114497" @default.
- W4313492708 startingPage "114497" @default.
- W4313492708 abstract "Previous studies have revealed nephrotoxicity, hepatotoxicity, subchronic developmental and reproductive toxicity in rats exposed to fluorotelomer alcohol (FTOH). However, the effects of embryonic 6:2 FTOH exposure on the reproductive system of offspring mice remain unclear. The purpose of this study is to explore the reproductive toxic effects of embryonic 6:2 FTOH exposure on offspring male mice and the related molecular mechanisms. Therefore, the pregnant mice were given corn oil or 6:2 FTOH by gavage from gestational days 12.5-21.5. The results demonstrated that embryonic 6:2 FTOH exposure resulted in disrupted testicular structure, low expression of tight junction protein between Sertoli cells (SCs), impaired blood-testis barrier (BTB) formation and maturation, reduced sperm viability and increased malformation, and induced testicular inflammation in the offspring of mice. Further in vitro studies showed that 6:2 FTOH treatment upregulated MMP-8 expression by activating AKT/NF-κB signaling pathway, which in turn enhanced occludin cleavage leading to the disruption of SCs barrier integrity. In summary, this study demonstrated that 6:2 FTOH exposure caused reproductive dysfunction in male offspring through disruption of BTB, which provided new insights into the effects of 6:2 FTOH exposure on the offspring." @default.
- W4313492708 created "2023-01-06" @default.
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- W4313492708 date "2023-01-01" @default.
- W4313492708 modified "2023-10-17" @default.
- W4313492708 title "Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice" @default.
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- W4313492708 doi "https://doi.org/10.1016/j.ecoenv.2023.114497" @default.
- W4313492708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608565" @default.
- W4313492708 hasPublicationYear "2023" @default.
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