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• W4313492788 endingPage "199040" @default.
• W4313492788 startingPage "199040" @default.
• W4313492788 abstract "Zika virus (ZIKV) is an arbovirus that belongs to the Flaviviridae family and inflammatory responses play a critical role in ZIKV pathogenesis. As a first-line defense, monocytes are key components of innate immunity and host response to viruses. Monocytes are considered the earliest blood cell type to be infected by ZIKV and have been shown to be associated with ZIKV pathogenesis. The first ZIKV epidemic was reported in Africa and Asia although, it is less well known whether African- and Asian- lineages of ZIKV have different impacts on host immune response. We studied the pro-inflammatory and antiviral response of ZIKV-infected monocytes using publicly available RNA-seq analysis (GSE103114). We compared the transcriptomic profiles of human monocytes infected with ZIKV Puerto Rico strain (PRVABC59), American-Asian lineage, and ZIKV Nigeria strain (IBH30656), African lineage. We validated RNA-seq results by ELISA or RT-qPCR, in human monocytes infected with a clinical isolate of ZIKV from Colombia (American-Asian lineage), or with ZIKV from Dakar (African lineage). The transcriptomic analysis showed that ZIKV Puerto Rico strain promotes a higher pro-inflammatory response through TLR2 signaling and NF-kB activation and induces a strong IL27-dependent antiviral activity than ZIKV Nigeria strain. Furthermore, human monocytes are more susceptible to infection with ZIKV from Colombia than ZIKV from Dakar. Likewise, Colombian ZIKV isolate activated IL27 signaling and induced a robust antiviral response in an IFN-independent manner. Moreover, we show that treatment of monocytes with IL27 results in decreased release of ZIKV particles in a dose-dependent manner with an EC50 =2.870 ng/mL for ZIKV from Colombia and EC50 =10.23 ng/mL to ZIKV from Dakar. These findings highlight the differential inflammatory response and antiviral activity of monocytes infected with different lineages of ZIKV and may help better management of ZIKV-infected patients." @default.
• W4313492788 created "2023-01-06" @default.
• W4313492788 creator A5033625366 @default.
• W4313492788 creator A5071650360 @default.
• W4313492788 creator A5091437568 @default.
• W4313492788 date "2023-02-01" @default.
• W4313492788 modified "2023-10-05" @default.
• W4313492788 title "American-Asian- and African lineages of Zika virus induce differential pro-inflammatory and Interleukin 27-dependent antiviral responses in human monocytes" @default.
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• W4313492788 cites W2016956768 @default.
• W4313492788 cites W2020482563 @default.
• W4313492788 cites W2058228196 @default.
• W4313492788 cites W2085237060 @default.
• W4313492788 cites W2086495450 @default.
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• W4313492788 cites W2156013098 @default.
• W4313492788 cites W2156414024 @default.
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• W4313492788 cites W2160328264 @default.
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• W4313492788 cites W2172292246 @default.
• W4313492788 cites W2191654227 @default.
• W4313492788 cites W2206554718 @default.
• W4313492788 cites W2224665992 @default.
• W4313492788 cites W2311276862 @default.
• W4313492788 cites W2327959547 @default.
• W4313492788 cites W2346484133 @default.
• W4313492788 cites W2395416726 @default.
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• W4313492788 cites W2735527928 @default.
• W4313492788 cites W2759977828 @default.
• W4313492788 cites W2762425132 @default.
• W4313492788 cites W2765173411 @default.
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• W4313492788 cites W2782327081 @default.
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• W4313492788 cites W2819964150 @default.
• W4313492788 cites W2883180486 @default.
• W4313492788 cites W2885564449 @default.
• W4313492788 cites W2885679300 @default.
• W4313492788 cites W2886167793 @default.
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• W4313492788 cites W3036268819 @default.
• W4313492788 cites W3089013511 @default.
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• W4313492788 cites W3184486712 @default.
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• W4313492788 doi "https://doi.org/10.1016/j.virusres.2023.199040" @default.
• W4313492788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610657" @default.
• W4313492788 hasPublicationYear "2023" @default.
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