Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313493312> ?p ?o ?g. }
- W4313493312 abstract "Abstract Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect." @default.
- W4313493312 created "2023-01-06" @default.
- W4313493312 creator A5005663670 @default.
- W4313493312 creator A5006876162 @default.
- W4313493312 creator A5011866803 @default.
- W4313493312 creator A5018262789 @default.
- W4313493312 creator A5025485180 @default.
- W4313493312 creator A5026580896 @default.
- W4313493312 creator A5030553328 @default.
- W4313493312 creator A5035901179 @default.
- W4313493312 creator A5044043542 @default.
- W4313493312 creator A5046078938 @default.
- W4313493312 creator A5047189927 @default.
- W4313493312 creator A5047658318 @default.
- W4313493312 creator A5063027009 @default.
- W4313493312 creator A5067148171 @default.
- W4313493312 creator A5070837221 @default.
- W4313493312 creator A5075415907 @default.
- W4313493312 creator A5075851507 @default.
- W4313493312 creator A5075882111 @default.
- W4313493312 creator A5079051154 @default.
- W4313493312 creator A5080774279 @default.
- W4313493312 creator A5086623549 @default.
- W4313493312 creator A5086691130 @default.
- W4313493312 creator A5091314291 @default.
- W4313493312 date "2023-01-04" @default.
- W4313493312 modified "2023-10-18" @default.
- W4313493312 title "Lithiated porous silicon nanowires stimulate periodontal regeneration" @default.
- W4313493312 cites W1664276307 @default.
- W4313493312 cites W1974678166 @default.
- W4313493312 cites W1987956036 @default.
- W4313493312 cites W1990523205 @default.
- W4313493312 cites W1999892948 @default.
- W4313493312 cites W2010517016 @default.
- W4313493312 cites W2020724077 @default.
- W4313493312 cites W2021039545 @default.
- W4313493312 cites W2039493020 @default.
- W4313493312 cites W2046420363 @default.
- W4313493312 cites W2049306818 @default.
- W4313493312 cites W2063620211 @default.
- W4313493312 cites W2070185729 @default.
- W4313493312 cites W2070364826 @default.
- W4313493312 cites W2073887259 @default.
- W4313493312 cites W2078636870 @default.
- W4313493312 cites W2100366177 @default.
- W4313493312 cites W2105866363 @default.
- W4313493312 cites W2105926839 @default.
- W4313493312 cites W2123861916 @default.
- W4313493312 cites W2142904252 @default.
- W4313493312 cites W2155216263 @default.
- W4313493312 cites W2322687913 @default.
- W4313493312 cites W2421346361 @default.
- W4313493312 cites W2473604141 @default.
- W4313493312 cites W2527903921 @default.
- W4313493312 cites W2568491470 @default.
- W4313493312 cites W2581095595 @default.
- W4313493312 cites W2594427730 @default.
- W4313493312 cites W2742439464 @default.
- W4313493312 cites W2782037904 @default.
- W4313493312 cites W2787436741 @default.
- W4313493312 cites W2888419818 @default.
- W4313493312 cites W2898633283 @default.
- W4313493312 cites W2913565319 @default.
- W4313493312 cites W2947513705 @default.
- W4313493312 cites W2986495815 @default.
- W4313493312 cites W3092320582 @default.
- W4313493312 cites W3108208736 @default.
- W4313493312 cites W3139406108 @default.
- W4313493312 doi "https://doi.org/10.21203/rs.3.rs-1020270/v1" @default.
- W4313493312 hasPublicationYear "2023" @default.
- W4313493312 type Work @default.
- W4313493312 citedByCount "0" @default.
- W4313493312 crossrefType "posted-content" @default.
- W4313493312 hasAuthorship W4313493312A5005663670 @default.
- W4313493312 hasAuthorship W4313493312A5006876162 @default.
- W4313493312 hasAuthorship W4313493312A5011866803 @default.
- W4313493312 hasAuthorship W4313493312A5018262789 @default.
- W4313493312 hasAuthorship W4313493312A5025485180 @default.
- W4313493312 hasAuthorship W4313493312A5026580896 @default.
- W4313493312 hasAuthorship W4313493312A5030553328 @default.
- W4313493312 hasAuthorship W4313493312A5035901179 @default.
- W4313493312 hasAuthorship W4313493312A5044043542 @default.
- W4313493312 hasAuthorship W4313493312A5046078938 @default.
- W4313493312 hasAuthorship W4313493312A5047189927 @default.
- W4313493312 hasAuthorship W4313493312A5047658318 @default.
- W4313493312 hasAuthorship W4313493312A5063027009 @default.
- W4313493312 hasAuthorship W4313493312A5067148171 @default.
- W4313493312 hasAuthorship W4313493312A5070837221 @default.
- W4313493312 hasAuthorship W4313493312A5075415907 @default.
- W4313493312 hasAuthorship W4313493312A5075851507 @default.
- W4313493312 hasAuthorship W4313493312A5075882111 @default.
- W4313493312 hasAuthorship W4313493312A5079051154 @default.
- W4313493312 hasAuthorship W4313493312A5080774279 @default.
- W4313493312 hasAuthorship W4313493312A5086623549 @default.
- W4313493312 hasAuthorship W4313493312A5086691130 @default.
- W4313493312 hasAuthorship W4313493312A5091314291 @default.
- W4313493312 hasBestOaLocation W43134933121 @default.
- W4313493312 hasConcept C134018914 @default.
- W4313493312 hasConcept C136229726 @default.
- W4313493312 hasConcept C151279780 @default.