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- W4313493401 abstract "The natriuretic peptides (NPs) hormone family, which consists mainly of atrial, brain, and C-type NPs (ANP, BNP, and CNP), play diverse roles in mammalian species, ranging from renal, cardiac, endocrine, neural, and vascular hemodynamics to metabolic regulations, immune responsiveness, and energy distributions. Over the last four decades, new data has transpired regarding the biochemical and molecular compositions, signaling mechanisms, and physiological and pathophysiological functions of NPs and their receptors. NPs are incremented mainly in eliciting natriuretic, diuretic, endocrine, vasodilatory, and neurological activities, along with antiproliferative, antimitogenic, antiinflammatory, and antifibrotic responses. The main locus responsible in the biological and physiological regulatory actions of NPs (ANP and BNP) is the plasma membrane guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), a member of the growing multi-limbed GC family of receptors. Advances in this field have provided tremendous insights into the critical role of Npr1 (encoding GC-A/NPRA) in the reduction of fluid volume and blood pressure homeostasis, protection against renal and cardiac remodeling, and moderation and mediation of neurological disorders. The generation and use of genetically engineered animals, including gene-targeted (gene-knockout and gene-duplication) and transgenic mutant mouse models has revealed and clarified the varied roles and pleiotropic functions of GC-A/NPRA in vivo in intact animals. This review provides a chronological development of the biochemical, molecular, physiological, and pathophysiological functions of GC-A/NPRA, including signaling pathways, genomics, and gene regulation in both normal and disease states." @default.
- W4313493401 created "2023-01-06" @default.
- W4313493401 creator A5013084644 @default.
- W4313493401 date "2023-01-04" @default.
- W4313493401 modified "2023-10-05" @default.
- W4313493401 title "Guanylyl cyclase/natriuretic peptide receptor-A: Identification, molecular characterization, and physiological genomics" @default.
- W4313493401 cites W101207630 @default.
- W4313493401 cites W137536100 @default.
- W4313493401 cites W1481270293 @default.
- W4313493401 cites W148648419 @default.
- W4313493401 cites W1496216397 @default.
- W4313493401 cites W1500832403 @default.
- W4313493401 cites W1510010134 @default.
- W4313493401 cites W1520611194 @default.
- W4313493401 cites W1525728123 @default.
- W4313493401 cites W1534361617 @default.
- W4313493401 cites W1541662023 @default.
- W4313493401 cites W1542279315 @default.
- W4313493401 cites W1545530316 @default.
- W4313493401 cites W1552901871 @default.
- W4313493401 cites W1556568434 @default.
- W4313493401 cites W1559048099 @default.
- W4313493401 cites W1562380669 @default.
- W4313493401 cites W1564187709 @default.
- W4313493401 cites W1573211116 @default.
- W4313493401 cites W1574096163 @default.
- W4313493401 cites W1579903794 @default.
- W4313493401 cites W1596410157 @default.
- W4313493401 cites W1599050967 @default.
- W4313493401 cites W1603537849 @default.
- W4313493401 cites W1607672162 @default.
- W4313493401 cites W1610892577 @default.
- W4313493401 cites W1775131150 @default.
- W4313493401 cites W1836582633 @default.
- W4313493401 cites W1892530357 @default.
- W4313493401 cites W1904859085 @default.
- W4313493401 cites W1905627889 @default.
- W4313493401 cites W1912249044 @default.
- W4313493401 cites W193459508 @default.
- W4313493401 cites W1939456349 @default.
- W4313493401 cites W1963513906 @default.
- W4313493401 cites W1964194790 @default.
- W4313493401 cites W1964409706 @default.
- W4313493401 cites W1966513216 @default.
- W4313493401 cites W1968573434 @default.
- W4313493401 cites W1970546352 @default.
- W4313493401 cites W1974159422 @default.
- W4313493401 cites W1975790899 @default.
- W4313493401 cites W1976389091 @default.
- W4313493401 cites W1978038902 @default.
- W4313493401 cites W1978254878 @default.
- W4313493401 cites W1982891639 @default.
- W4313493401 cites W1983094993 @default.
- W4313493401 cites W1983311124 @default.
- W4313493401 cites W1983509986 @default.
- W4313493401 cites W1984092953 @default.
- W4313493401 cites W1984893737 @default.
- W4313493401 cites W1985761104 @default.
- W4313493401 cites W1989352995 @default.
- W4313493401 cites W1990075625 @default.
- W4313493401 cites W1991102782 @default.
- W4313493401 cites W1991228692 @default.
- W4313493401 cites W1991490897 @default.
- W4313493401 cites W1993577260 @default.
- W4313493401 cites W1995920288 @default.
- W4313493401 cites W1997272952 @default.
- W4313493401 cites W1997409050 @default.
- W4313493401 cites W1998139028 @default.
- W4313493401 cites W1998371231 @default.
- W4313493401 cites W1998465616 @default.
- W4313493401 cites W1998904527 @default.
- W4313493401 cites W1999876831 @default.
- W4313493401 cites W2002527015 @default.
- W4313493401 cites W2003235464 @default.
- W4313493401 cites W2003309225 @default.
- W4313493401 cites W2004456062 @default.
- W4313493401 cites W2004801897 @default.
- W4313493401 cites W2005982860 @default.
- W4313493401 cites W2006512908 @default.
- W4313493401 cites W2007034430 @default.
- W4313493401 cites W2008478256 @default.
- W4313493401 cites W2008742005 @default.
- W4313493401 cites W2009800112 @default.
- W4313493401 cites W2010730039 @default.
- W4313493401 cites W2011632934 @default.
- W4313493401 cites W2014252953 @default.
- W4313493401 cites W2015012568 @default.
- W4313493401 cites W2015135418 @default.
- W4313493401 cites W2015860873 @default.
- W4313493401 cites W2016476207 @default.
- W4313493401 cites W2017532904 @default.
- W4313493401 cites W2018114325 @default.
- W4313493401 cites W2018491949 @default.
- W4313493401 cites W2018559689 @default.
- W4313493401 cites W2018835929 @default.
- W4313493401 cites W2018985944 @default.
- W4313493401 cites W2019547038 @default.
- W4313493401 cites W2019592403 @default.
- W4313493401 cites W2019593637 @default.
- W4313493401 cites W2020211786 @default.