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• W4313493407 abstract "Abstract Purpose We examined the impact of using a probiotic containing three different Lactobacilli (3L) on the gut microbiome of rats following cyclophosphamide (CTX) treatment. CTX corresponded to chemotherapy which is used for human cancer treatment and known to have adversive effects on the immune system. Methods We conducted our experiment with ten rats in five different experimental groups which included control, CTX treated, and then low, medium, and high probiotic treatment with CTX treatment. Of these ten rats in each group, we sequenced the stool of three of them using both ITS and 16S sequencing. We then went on to examine the taxonomic composition of these samples to determine whether probiotic treatment helped the rat’s microbiome return to similar structure as the control rats. Results We used Illumina MiSeq sequencing to generate sequencing data from microbial genomic DNA libraries, which is useful for testing the effects of 3L on bacteria and fungi. Microbiome analysis, phylogenetic and classification reports, and community data have all backed up the experiments and findings that 3L had a significant positive impact on the microbiome. Furthermore, the effect on specific metabolic pathways aids in deriving the study’s conclusion (use of 3L in chemotherapy) to the mode of action, mechanistically by correcting microbiota composition and enhancing specific gut metabolic functions. Conclusions Through experimental results using an in vivo model, we suggested the role of novel natural probiotics 3L, 3 Lactobacilli in the establishment of a strong and sustainable beneficial healthy gut flora, after CTX chemotherapy. We suggested some new adjuvants to chemotherapy as drugs + lactobacillus treament using the rat CTX model (immunosuppression caused by cyclophosphamide). Furthermore, in numerous studies that reported the use of probiotics involving Lactobacillus in post-chemo or post-surgical procedures, we proposed a new probiotic formulation ( L. acidophilus + L. casei + L. plantarum ) to be further studied and explored in the prevention of health condition loss by alteration of the general immune system." @default.
• W4313493407 created "2023-01-06" @default.
• W4313493407 creator A5004585663 @default.
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• W4313493407 creator A5087975975 @default.
• W4313493407 date "2023-01-04" @default.
• W4313493407 modified "2023-10-01" @default.
• W4313493407 title "3L, three-Lactobacilli on recovering of microbiome and immune-damage by cyclophosphamide chemotherapy —A pilot experiment—" @default.
• W4313493407 cites W1586032508 @default.
• W4313493407 cites W1883997870 @default.
• W4313493407 cites W1914453902 @default.
• W4313493407 cites W1974028415 @default.
• W4313493407 cites W1976939092 @default.
• W4313493407 cites W1982595964 @default.
• W4313493407 cites W1984046947 @default.
• W4313493407 cites W1988925586 @default.
• W4313493407 cites W1990955560 @default.
• W4313493407 cites W1995393174 @default.
• W4313493407 cites W1996513377 @default.
• W4313493407 cites W2002861821 @default.
• W4313493407 cites W2005971420 @default.
• W4313493407 cites W2006156042 @default.
• W4313493407 cites W2006367006 @default.
• W4313493407 cites W2010084960 @default.
• W4313493407 cites W2015561372 @default.
• W4313493407 cites W2021295767 @default.
• W4313493407 cites W2032082852 @default.
• W4313493407 cites W2046928699 @default.
• W4313493407 cites W2047902191 @default.
• W4313493407 cites W2055245266 @default.
• W4313493407 cites W2072145140 @default.
• W4313493407 cites W2072970694 @default.
• W4313493407 cites W2077088073 @default.
• W4313493407 cites W2078224825 @default.
• W4313493407 cites W2086062223 @default.
• W4313493407 cites W2086927107 @default.
• W4313493407 cites W2097808005 @default.
• W4313493407 cites W2105329815 @default.
• W4313493407 cites W2105549148 @default.
• W4313493407 cites W2107794977 @default.
• W4313493407 cites W2114807146 @default.
• W4313493407 cites W2115387350 @default.
• W4313493407 cites W2117692326 @default.
• W4313493407 cites W2124351063 @default.
• W4313493407 cites W2125826054 @default.
• W4313493407 cites W2126346076 @default.
• W4313493407 cites W2127743008 @default.
• W4313493407 cites W2133856765 @default.
• W4313493407 cites W2138327697 @default.
• W4313493407 cites W2143442621 @default.
• W4313493407 cites W2143842034 @default.
• W4313493407 cites W2145897416 @default.
• W4313493407 cites W2148420701 @default.
• W4313493407 cites W2150777859 @default.
• W4313493407 cites W2151267730 @default.
• W4313493407 cites W2151333962 @default.
• W4313493407 cites W2153604508 @default.
• W4313493407 cites W2153832854 @default.
• W4313493407 cites W2155747865 @default.
• W4313493407 cites W2160947363 @default.
• W4313493407 cites W2167336969 @default.
• W4313493407 cites W2168909179 @default.
• W4313493407 cites W2170940180 @default.
• W4313493407 cites W2171942860 @default.
• W4313493407 cites W2232557022 @default.
• W4313493407 cites W2258061020 @default.
• W4313493407 cites W2278396373 @default.
• W4313493407 cites W2346673016 @default.
• W4313493407 cites W2401404581 @default.
• W4313493407 cites W2440692448 @default.
• W4313493407 cites W2486068312 @default.
• W4313493407 cites W2513506562 @default.
• W4313493407 cites W2551729158 @default.
• W4313493407 cites W2559352823 @default.
• W4313493407 cites W2584950134 @default.
• W4313493407 cites W2585025165 @default.
• W4313493407 cites W2586897522 @default.
• W4313493407 cites W2587517604 @default.
• W4313493407 cites W2606594686 @default.
• W4313493407 cites W2610723832 @default.
• W4313493407 cites W2736808617 @default.
• W4313493407 cites W2745821917 @default.
• W4313493407 cites W2751853585 @default.
• W4313493407 cites W2762408691 @default.
• W4313493407 cites W2765314233 @default.
• W4313493407 cites W2767088268 @default.
• W4313493407 cites W2767627499 @default.
• W4313493407 cites W2768096340 @default.
• W4313493407 cites W2771554323 @default.
• W4313493407 cites W2777353230 @default.
• W4313493407 cites W2783111588 @default.
• W4313493407 cites W2785328545 @default.
• W4313493407 cites W2790276913 @default.
• W4313493407 cites W2801168210 @default.
• W4313493407 cites W2803201481 @default.

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