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• W4313494619 endingPage "123" @default.
• W4313494619 startingPage "123" @default.
• W4313494619 abstract "The global prevalence of diabetes continues to increase partly due to rapid urbanization and an increase in the aging population. Consequently, this is associated with a parallel increase in the prevalence of diabetic vascular complications which significantly worsen the burden of diabetes. For these diabetic vascular complications, there is still an unmet need for safe and effective alternative/adjuvant therapeutic interventions. There is also an increasing urge for therapeutic options to come from natural products such as plants. Hyperglycemia-induced oxidative stress is central to the development of diabetes and diabetic complications. Furthermore, oxidative stress-induced inflammation and insulin resistance are central to endothelial damage and the progression of diabetic complications. Human and animal studies have shown that polyphenols could reduce oxidative stress, hyperglycemia, and prevent diabetic complications including diabetic retinopathy, diabetic nephropathy, and diabetic peripheral neuropathy. Part of the therapeutic effects of polyphenols is attributed to their modulatory effect on endogenous antioxidant systems. This review attempts to summarize the established effects of polyphenols on endogenous antioxidant systems from the literature. Moreover, potential therapeutic strategies for harnessing the potential benefits of polyphenols for diabetic vascular complications are also discussed." @default.
• W4313494619 created "2023-01-06" @default.
• W4313494619 creator A5038591415 @default.
• W4313494619 creator A5083694510 @default.
• W4313494619 creator A5091271878 @default.
• W4313494619 date "2023-01-04" @default.
• W4313494619 modified "2023-10-14" @default.
• W4313494619 title "Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications" @default.
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