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• W4313500586 abstract "In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed to assess and determine the possible pharmacological activities of A. maculatum and evaluate its potential to act as a wound care plant.The antioxidant and antimicrobial activities of A. maculatum were investigated using excisional in vivo and in vitro wound healing mouse models. A total of 32 Balb-c mice were used, which were equally, divided into four groups: saline control group, control group, A. maculatum group, and Centella asiatica extract group. Treatment applications were performed topically once per day. Wound area narrowing, wound healing percentage, and epithelialization time were analyzed.A. maculatum application supported the healing process in in vivo and in vitro wound models. A. maculatum contributed to the healing process by promoting granulation tissue formation, epidermal regeneration, and angiogenesis.Wound healing is a complex and well-organized process that requires communication between cells. The antioxidant and antimicrobial activities of A. maculatum extract have been determined by current studies. A. maculatum extract may provide significant benefits in promoting the wound healing process.Bu araştırmada antioksidan özelliklerini değerlendirmek için Arum maculatum bitkisi seçilmiştir. Bildiğimiz kadarıyla A. maculatum meyvelerinin metanol özünün yara iyileştirici aktivitesi ilk kez bu çalışmada rapor edilmiştir. Bu çalışma, A. maculatum’un olası farmakolojik aktivitelerini belirlemek, değerlendirmek ve bir yara tedavi edici bitki olarak etki gösterme potansiyelini değerlendirmek içindi.A. maculatum’un antioksidan ve antimikrobiyal aktiviteleri, farelerde eksizyonel in vivo ve in vitro yara iyileşme modelleri kulanılarak araştırılmıştır. Toplamda 32 Balb-c fare kullanılmış olup salin kontrol grubu, kontrol grubu, A. maculatum uygulanan grup ve Centella asiatica özütü uygulanan grup olmak üzere 4 gruba ayrılmıştır. Tedavi uygulamaları günde bir kez topikal olarak gerçekleştirilmiştir. Skar alanı hacminde gerçekleşen değişim, yara iyileşme yüzdesi ve epitelizasyon süresi analiz edilmiştir.A. maculatum uygulaması in vivo ve in vitro yara modelinde iyileşme sürecini desteklemiştir. A. maculatum, granülasyon dokusunu artırarak iyileşme sürecine katkıda bulunmuş, epidermal rejenerasyonu ve anjiyogenezi artırmıştır.Yara iyileşmesi, hücreler arası iletişimi gerektiren karmaşık ve iyi organize edilmiş bir süreçtir. Mevcut çalışmalar doğrultusunda antioksidan ve antimikrobiyal aktivitesi belirlenmiş olan A. maculatum özü, yara iyileşme sürecinin desteklenmesinde önemli bir fayda sağlayabilir." @default.
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• W4313500586 date "2023-03-27" @default.
• W4313500586 modified "2023-10-17" @default.
• W4313500586 title "Wound Healing Activity of Arum Maculatum" @default.
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• W4313500586 doi "https://doi.org/10.4274/mmj.galenos.2022.73368" @default.
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