FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313502456> ?p ?o ?g. }

• W4313502456 endingPage "19" @default.
• W4313502456 startingPage "19" @default.
• W4313502456 abstract "The antimicrobial properties of proline-rich Aedes aegypti decapeptide TMOF (AeaTMOF) and oncocin112 (1-13) were compared. Incubations with multidrug-resistant Escherichia coli cells showed that AeaTMOF (5 mM) was able to completely inhibit bacterial cell growth, whereas oncocin112 (1-13) (20 mM) partially inhibited bacterial growth as compared with bacterial cells that were not multidrug-resistant cells. AeaTMOF (5 mM) was very effective against Acinetobacter baumannii and Pseudomonas aeruginosa, completely inhibiting cell growth during 15 h incubations. AeaTMOF (5 mM) completely inhibited the Gram-positive bacteria Staphylococcus aureus and Bacillus thurengiensis sups. Israelensis cell growth, whereas oncocin112 (1-13) (10 and 20 mM) failed to affect bacterial cell growth. E. coli cells that lack the SbmA transporter were inhibited by AeaTMOF (5 mM) and not by oncocin112 (1-13) (10 to 20 mM), indicating that AeaTMOF can use other bacterial transporters than SbmA that is mainly used by proline-rich antimicrobial peptides. Incubation of E. coli cells with NaAzide showed that AeaTMOF does not use ABC-like transporters that use ATP hydrolysis to import molecules into bacterial cells. Three-dimensional modeling and docking of AeaTMOF to SbmA and MdtM transporters showed that AeaTMOF can bind these proteins, and the binding location of AeaTMOF inside these protein transporters allows AeaTMOF to be transported into the bacterial cytosol. These results show that AeaTMOF can be used as a future antibacterial agent against both multidrug-resistant Gram-positive and -negative bacteria." @default.
• W4313502456 created "2023-01-06" @default.
• W4313502456 creator A5074773498 @default.
• W4313502456 creator A5081602458 @default.
• W4313502456 creator A5086095963 @default.
• W4313502456 date "2022-12-21" @default.
• W4313502456 modified "2023-10-03" @default.
• W4313502456 title "Bactericidal Properties of Proline-Rich Aedes aegypti Trypsin Modulating Oostatic Factor (AeaTMOF)" @default.
• W4313502456 cites W1487871178 @default.
• W4313502456 cites W1863216998 @default.
• W4313502456 cites W1878404532 @default.
• W4313502456 cites W1894942982 @default.
• W4313502456 cites W1912107272 @default.
• W4313502456 cites W1939757033 @default.
• W4313502456 cites W1977276752 @default.
• W4313502456 cites W1980111518 @default.
• W4313502456 cites W1986191025 @default.
• W4313502456 cites W1989998611 @default.
• W4313502456 cites W2004572827 @default.
• W4313502456 cites W2007524080 @default.
• W4313502456 cites W2012115019 @default.
• W4313502456 cites W2016333765 @default.
• W4313502456 cites W2017359886 @default.
• W4313502456 cites W2020799333 @default.
• W4313502456 cites W2029377282 @default.
• W4313502456 cites W2048137852 @default.
• W4313502456 cites W2048248135 @default.
• W4313502456 cites W2052130550 @default.
• W4313502456 cites W2058429414 @default.
• W4313502456 cites W2060306551 @default.
• W4313502456 cites W2074858437 @default.
• W4313502456 cites W2079339594 @default.
• W4313502456 cites W2081032349 @default.
• W4313502456 cites W2099099776 @default.
• W4313502456 cites W2105751124 @default.
• W4313502456 cites W2111611477 @default.
• W4313502456 cites W2112537322 @default.
• W4313502456 cites W2115486016 @default.
• W4313502456 cites W2130479394 @default.
• W4313502456 cites W2132629607 @default.
• W4313502456 cites W2135533782 @default.
• W4313502456 cites W2144239598 @default.
• W4313502456 cites W2152301430 @default.
• W4313502456 cites W2153255725 @default.
• W4313502456 cites W2159614853 @default.
• W4313502456 cites W2161983628 @default.
• W4313502456 cites W2163161948 @default.
• W4313502456 cites W2192685225 @default.
• W4313502456 cites W2580811139 @default.
• W4313502456 cites W2737953146 @default.
• W4313502456 cites W2751523357 @default.
• W4313502456 cites W2769205803 @default.
• W4313502456 cites W2911964808 @default.
• W4313502456 cites W3083406432 @default.
• W4313502456 cites W3174628804 @default.
• W4313502456 cites W3213743547 @default.
• W4313502456 cites W3214404244 @default.
• W4313502456 cites W4224034220 @default.
• W4313502456 cites W4247333866 @default.
• W4313502456 doi "https://doi.org/10.3390/life13010019" @default.
• W4313502456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36675967" @default.
• W4313502456 hasPublicationYear "2022" @default.
• W4313502456 type Work @default.
• W4313502456 citedByCount "1" @default.
• W4313502456 countsByYear W43135024562023 @default.
• W4313502456 crossrefType "journal-article" @default.
• W4313502456 hasAuthorship W4313502456A5074773498 @default.
• W4313502456 hasAuthorship W4313502456A5081602458 @default.
• W4313502456 hasAuthorship W4313502456A5086095963 @default.
• W4313502456 hasBestOaLocation W43135024561 @default.
• W4313502456 hasConcept C104317684 @default.
• W4313502456 hasConcept C173758957 @default.
• W4313502456 hasConcept C17741926 @default.
• W4313502456 hasConcept C19655278 @default.
• W4313502456 hasConcept C2776315533 @default.
• W4313502456 hasConcept C2777637488 @default.
• W4313502456 hasConcept C2777775583 @default.
• W4313502456 hasConcept C2779707156 @default.
• W4313502456 hasConcept C2779815552 @default.
• W4313502456 hasConcept C4937899 @default.
• W4313502456 hasConcept C515207424 @default.
• W4313502456 hasConcept C523546767 @default.
• W4313502456 hasConcept C54355233 @default.
• W4313502456 hasConcept C547475151 @default.
• W4313502456 hasConcept C55493867 @default.
• W4313502456 hasConcept C59822182 @default.
• W4313502456 hasConcept C62112901 @default.
• W4313502456 hasConcept C86803240 @default.
• W4313502456 hasConcept C89423630 @default.
• W4313502456 hasConceptScore W4313502456C104317684 @default.
• W4313502456 hasConceptScore W4313502456C173758957 @default.
• W4313502456 hasConceptScore W4313502456C17741926 @default.
• W4313502456 hasConceptScore W4313502456C19655278 @default.
• W4313502456 hasConceptScore W4313502456C2776315533 @default.
• W4313502456 hasConceptScore W4313502456C2777637488 @default.
• W4313502456 hasConceptScore W4313502456C2777775583 @default.
• W4313502456 hasConceptScore W4313502456C2779707156 @default.
• W4313502456 hasConceptScore W4313502456C2779815552 @default.

• next