Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313503240> ?p ?o ?g. }
- W4313503240 endingPage "10" @default.
- W4313503240 startingPage "10" @default.
- W4313503240 abstract "The plasma membrane (PM) serves multiple functions to support cell activities with its heterogeneous molecular distribution. Fatty acids (FAs) are hydrophobic components of the PM whose saturation and length determine the membrane's physical properties. The FA distribution contributes to the PM's lateral heterogeneity. However, the distribution of PM FAs is poorly understood. Here, we proposed the FA cluster hypothesis, which suggested that FAs on the PM exist as clusters. By the optogenetic tool translocating the endoplasmic reticulum (ER), we were able to manipulate the distribution of PM FAs. We used time-of-flight combined secondary ion mass spectrometry (TOF-SIMS) to image PM FAs and discovered that PM FAs were presented and distributed as clusters and are also manipulated as clusters. We also found the existence of multi-FA clusters formed by the colocalization of more than one FA. Our optogenetic tool also decreased the clustering degree of FA clusters and the formation probability of multi-FA clusters. This research opens up new avenues and perspectives to study PM heterogeneity from an FA perspective. This research also suggests a possible treatment for diseases caused by PM lipid aggregation and furnished a convenient tool for therapeutic development." @default.
- W4313503240 created "2023-01-06" @default.
- W4313503240 creator A5001491308 @default.
- W4313503240 creator A5007914982 @default.
- W4313503240 creator A5016758250 @default.
- W4313503240 creator A5025068088 @default.
- W4313503240 creator A5025963123 @default.
- W4313503240 creator A5041325123 @default.
- W4313503240 creator A5042224386 @default.
- W4313503240 creator A5044087081 @default.
- W4313503240 creator A5049755723 @default.
- W4313503240 creator A5050961061 @default.
- W4313503240 creator A5059462629 @default.
- W4313503240 creator A5059483223 @default.
- W4313503240 creator A5069557746 @default.
- W4313503240 creator A5073263487 @default.
- W4313503240 creator A5076822409 @default.
- W4313503240 creator A5091540596 @default.
- W4313503240 date "2022-12-20" @default.
- W4313503240 modified "2023-10-05" @default.
- W4313503240 title "Imaging and Manipulation of Plasma Membrane Fatty Acid Clusters Using TOF-SIMS Combined Optogenetics" @default.
- W4313503240 cites W1589964110 @default.
- W4313503240 cites W1596177457 @default.
- W4313503240 cites W1965180796 @default.
- W4313503240 cites W1966099069 @default.
- W4313503240 cites W1969461041 @default.
- W4313503240 cites W1982409013 @default.
- W4313503240 cites W1982555544 @default.
- W4313503240 cites W1991655565 @default.
- W4313503240 cites W1993357003 @default.
- W4313503240 cites W1999906821 @default.
- W4313503240 cites W2011668966 @default.
- W4313503240 cites W2012684669 @default.
- W4313503240 cites W2013825614 @default.
- W4313503240 cites W2018764547 @default.
- W4313503240 cites W2021882008 @default.
- W4313503240 cites W2030530833 @default.
- W4313503240 cites W2037584275 @default.
- W4313503240 cites W2042407928 @default.
- W4313503240 cites W2046189032 @default.
- W4313503240 cites W2051420724 @default.
- W4313503240 cites W2055708199 @default.
- W4313503240 cites W2064894346 @default.
- W4313503240 cites W2068749469 @default.
- W4313503240 cites W2074270956 @default.
- W4313503240 cites W2077692714 @default.
- W4313503240 cites W2078991664 @default.
- W4313503240 cites W2079076036 @default.
- W4313503240 cites W2079725368 @default.
- W4313503240 cites W2088929386 @default.
- W4313503240 cites W2092296126 @default.
- W4313503240 cites W2105329132 @default.
- W4313503240 cites W2118265926 @default.
- W4313503240 cites W2121936687 @default.
- W4313503240 cites W2124050414 @default.
- W4313503240 cites W2125872855 @default.
- W4313503240 cites W2136558879 @default.
- W4313503240 cites W2152311269 @default.
- W4313503240 cites W2163013798 @default.
- W4313503240 cites W2224425637 @default.
- W4313503240 cites W2300552860 @default.
- W4313503240 cites W2323309108 @default.
- W4313503240 cites W2330363999 @default.
- W4313503240 cites W2517211077 @default.
- W4313503240 cites W2557049181 @default.
- W4313503240 cites W2620369564 @default.
- W4313503240 cites W2623634870 @default.
- W4313503240 cites W2738122480 @default.
- W4313503240 cites W2767614677 @default.
- W4313503240 cites W2886012836 @default.
- W4313503240 cites W2896758254 @default.
- W4313503240 cites W2900182380 @default.
- W4313503240 cites W2965146728 @default.
- W4313503240 cites W2991315750 @default.
- W4313503240 cites W3000208018 @default.
- W4313503240 cites W3006868374 @default.
- W4313503240 cites W3011374555 @default.
- W4313503240 cites W3012714065 @default.
- W4313503240 cites W3135438354 @default.
- W4313503240 cites W3159305558 @default.
- W4313503240 cites W4210574564 @default.
- W4313503240 cites W4283654249 @default.
- W4313503240 cites W82875452 @default.
- W4313503240 doi "https://doi.org/10.3390/cells12010010" @default.
- W4313503240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36611804" @default.
- W4313503240 hasPublicationYear "2022" @default.
- W4313503240 type Work @default.
- W4313503240 citedByCount "2" @default.
- W4313503240 countsByYear W43135032402023 @default.
- W4313503240 crossrefType "journal-article" @default.
- W4313503240 hasAuthorship W4313503240A5001491308 @default.
- W4313503240 hasAuthorship W4313503240A5007914982 @default.
- W4313503240 hasAuthorship W4313503240A5016758250 @default.
- W4313503240 hasAuthorship W4313503240A5025068088 @default.
- W4313503240 hasAuthorship W4313503240A5025963123 @default.
- W4313503240 hasAuthorship W4313503240A5041325123 @default.
- W4313503240 hasAuthorship W4313503240A5042224386 @default.
- W4313503240 hasAuthorship W4313503240A5044087081 @default.