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• W4313503285 endingPage "32" @default.
• W4313503285 startingPage "32" @default.
• W4313503285 abstract "Sex-specific differences in behavior have been observed in anxiety and learning in children exposed to prenatal inflammation; however, whether these behaviors manifest differently by age is unknown. This study assesses possible behavioral changes due to in utero inflammation as a function of age in neonatal, juvenile, and adult animals and presents potential molecular targets for observed differences. CD-1 timed pregnant dams were injected in utero with lipopolysaccharide (LPS, 50 μg/animal) or saline at embryonic day 15. No differences in stress responses were measured by neonatal ultrasonic vocalizations between LPS- and saline-exposed groups of either sex. By contrast, prenatal inflammation caused a male-specific increase in anxiety in mature but not juvenile animals. Juvenile LPS-exposed females had decreased movement in open field testing that was not present in adult animals. We additionally observed improved memory retrieval after in utero LPS in the juvenile animals of both sexes, which in males may be related to a perseverative phenotype. However, there was an impairment of long-term memory in only adult LPS-exposed females. Finally, gene expression analyses revealed that LPS induced sex-specific changes in genes involved in hippocampal neurogenesis. In conclusion, intrauterine inflammation has age- and sex-specific effects on anxiety and learning that may correlate to sex-specific disruption of gene expression associated with neurogenesis in the hippocampus." @default.
• W4313503285 created "2023-01-06" @default.
• W4313503285 creator A5045249801 @default.
• W4313503285 creator A5048189307 @default.
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• W4313503285 creator A5055560807 @default.
• W4313503285 creator A5064984909 @default.
• W4313503285 creator A5068867322 @default.
• W4313503285 date "2022-12-20" @default.
• W4313503285 modified "2023-10-16" @default.
• W4313503285 title "Intrauterine Inflammation Leads to Select Sex- and Age-Specific Behavior and Molecular Differences in Mice" @default.
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• W4313503285 doi "https://doi.org/10.3390/ijms24010032" @default.
• W4313503285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36613475" @default.

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