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- W4313503353 abstract "Arterial stiffness is a major vascular complication of chronic kidney disease (CKD). The development of renal damage, hypertension, and increased pulse wave velocity (PWV) in CKD might be associated with an imbalance in bone morphogenetic proteins (BMP)-2 and BMP-7. Plasma BMP-2 and BMP-7 were determined by ELISA in CKD patients (stages I–III; n = 95) and Munich Wistar Frömter (MWF) rats. Age-matched Wistar rats were used as a control. The expression of BMP-2, BMP-7, and profibrotic and calcification factors was determined in kidney and perivascular adipose tissues (PVAT). BMP-2 was higher in stage III CKD patients compared to control subjects. BMP-7 was lower at any CKD stage compared to controls, with a significant further reduction in stage III patients. A similar imbalance was observed in MWF rats together with the increase in systolic (SBP) and diastolic blood pressure (DBP), or pulse wave velocity (PWV). MWF exhibited elevated urinary albumin excretion (UAE) and renal expression of BMP-2 or kidney damage markers, Kim-1 and Ngal, whereas renal BMP-7 was significantly lower than in Wistar rats. SBP, DBP, PWV, UAE, and plasma creatinine positively correlated with the plasma BMP-2/BMP-7 ratio. Periaortic and mesenteric PVAT from MWF rats showed an increased expression of BMP-2 and profibrotic and calcification markers compared to Wistar rats, together with a reduced BMP-7 expression. BMP-2 and BMP-7 imbalance in plasma, kidney, and PVATs is associated with vascular damage, suggesting a profibrotic/pro-calcifying propensity associated with progressive CKD. Thus, their combined analysis stratified by CKD stages might be of clinical interest to provide information about the degree of renal and vascular damage in CKD." @default.
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- W4313503353 date "2022-12-20" @default.
- W4313503353 modified "2023-10-03" @default.
- W4313503353 title "Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease" @default.
- W4313503353 cites W1490347034 @default.
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- W4313503353 cites W1966022628 @default.
- W4313503353 cites W1972528145 @default.
- W4313503353 cites W1973895552 @default.
- W4313503353 cites W1979055405 @default.
- W4313503353 cites W1981162405 @default.
- W4313503353 cites W1981228902 @default.
- W4313503353 cites W1981652784 @default.
- W4313503353 cites W1991174176 @default.
- W4313503353 cites W1993345123 @default.
- W4313503353 cites W1994867142 @default.
- W4313503353 cites W1994913277 @default.
- W4313503353 cites W1996978408 @default.
- W4313503353 cites W1999609975 @default.
- W4313503353 cites W2006020561 @default.
- W4313503353 cites W2007960009 @default.
- W4313503353 cites W2011543776 @default.
- W4313503353 cites W2011957610 @default.
- W4313503353 cites W2016091065 @default.
- W4313503353 cites W2033457930 @default.
- W4313503353 cites W2033872591 @default.
- W4313503353 cites W2036755333 @default.
- W4313503353 cites W2041870197 @default.
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- W4313503353 cites W2049880872 @default.
- W4313503353 cites W2051612201 @default.
- W4313503353 cites W2069249538 @default.
- W4313503353 cites W2070917109 @default.
- W4313503353 cites W2086306762 @default.
- W4313503353 cites W2095471709 @default.
- W4313503353 cites W2096537254 @default.
- W4313503353 cites W2103193122 @default.
- W4313503353 cites W2103321505 @default.
- W4313503353 cites W2114155130 @default.
- W4313503353 cites W2114245705 @default.
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- W4313503353 cites W2122995620 @default.
- W4313503353 cites W2123780246 @default.
- W4313503353 cites W2124415162 @default.
- W4313503353 cites W2127762602 @default.
- W4313503353 cites W2134074039 @default.
- W4313503353 cites W2139709244 @default.
- W4313503353 cites W2147834547 @default.
- W4313503353 cites W2150582334 @default.
- W4313503353 cites W2150989567 @default.
- W4313503353 cites W2153059487 @default.
- W4313503353 cites W2155965977 @default.
- W4313503353 cites W2157516811 @default.
- W4313503353 cites W2161152300 @default.
- W4313503353 cites W2161918376 @default.
- W4313503353 cites W2161924597 @default.
- W4313503353 cites W2168456732 @default.
- W4313503353 cites W2226330135 @default.
- W4313503353 cites W2312647260 @default.
- W4313503353 cites W2325464161 @default.
- W4313503353 cites W2587059999 @default.
- W4313503353 cites W2607031541 @default.
- W4313503353 cites W2803824505 @default.
- W4313503353 cites W2888589263 @default.
- W4313503353 cites W2904356389 @default.
- W4313503353 cites W2943197097 @default.
- W4313503353 cites W2992004306 @default.
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- W4313503353 doi "https://doi.org/10.3390/ijms24010040" @default.
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