FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313503701> ?p ?o ?g. }

• W4313503701 endingPage "1672" @default.
• W4313503701 startingPage "1661" @default.
• W4313503701 abstract "T cell function is central to immune reconstitution and control of residual chronic myeloid leukemia (CML) cells after treatment initiation and is associated with achieving deep molecular response as a prerequisite for treatment-free remission, the ultimate therapeutic goal in CML. ATP-pocket-binding tyrosine kinase inhibitors (TKIs) like imatinib, dasatinib, and nilotinib are widely used for treating CML, but they have shown to inhibit T cell function as an off-target effect. Therefore, we tested asciminib, the first-in-class BCR::ABL1 fusion protein inhibitor specifically targeting the ABL myristoyl pocket (STAMP) and compared its effects on T cell function with imatinib, dasatinib, and nilotinib. Whereas all four TKIs inhibited the expression of the co-stimulatory protein CD28, the amino acid transporter CD98, proliferation, and secretion of pro-inflammatory cytokines IFNγ, IL-6, and IL-17A upon T cell stimulation, asciminib had less impact on PD-1, activation markers, and IL-2 secretion. T cells treated with asciminib and the other TKIs maintained their ability to mobilize their respiratory capacity and glycolytic reserve, which is an important surrogate for metabolic fitness and flexibility. Overall, we found milder inhibitory effects of asciminib on T cell activation, which might be beneficial for the immunological control of residual CML cells." @default.
• W4313503701 created "2023-01-06" @default.
• W4313503701 creator A5003219667 @default.
• W4313503701 creator A5011903306 @default.
• W4313503701 creator A5019784391 @default.
• W4313503701 creator A5022485574 @default.
• W4313503701 creator A5024339059 @default.
• W4313503701 creator A5026639675 @default.
• W4313503701 creator A5044473182 @default.
• W4313503701 creator A5055880996 @default.
• W4313503701 creator A5088896290 @default.
• W4313503701 date "2023-01-05" @default.
• W4313503701 modified "2023-09-26" @default.
• W4313503701 title "Effects of the STAMP-inhibitor asciminib on T cell activation and metabolic fitness compared to tyrosine kinase inhibition by imatinib, dasatinib, and nilotinib" @default.
• W4313503701 cites W1893566975 @default.
• W4313503701 cites W1944753949 @default.
• W4313503701 cites W1969782565 @default.
• W4313503701 cites W1971992050 @default.
• W4313503701 cites W1974815398 @default.
• W4313503701 cites W1999742105 @default.
• W4313503701 cites W2001781763 @default.
• W4313503701 cites W2009600080 @default.
• W4313503701 cites W2015415347 @default.
• W4313503701 cites W2020103507 @default.
• W4313503701 cites W2021862851 @default.
• W4313503701 cites W2034862875 @default.
• W4313503701 cites W2036118441 @default.
• W4313503701 cites W2050897300 @default.
• W4313503701 cites W2051806138 @default.
• W4313503701 cites W2067305308 @default.
• W4313503701 cites W2083971244 @default.
• W4313503701 cites W2087595943 @default.
• W4313503701 cites W2092931465 @default.
• W4313503701 cites W2096148594 @default.
• W4313503701 cites W2096291727 @default.
• W4313503701 cites W2097855813 @default.
• W4313503701 cites W2131460312 @default.
• W4313503701 cites W2155493075 @default.
• W4313503701 cites W2171694114 @default.
• W4313503701 cites W2171847267 @default.
• W4313503701 cites W2313372982 @default.
• W4313503701 cites W2398660216 @default.
• W4313503701 cites W2526894720 @default.
• W4313503701 cites W2564723173 @default.
• W4313503701 cites W2610932550 @default.
• W4313503701 cites W2735590725 @default.
• W4313503701 cites W2767914526 @default.
• W4313503701 cites W2790027255 @default.
• W4313503701 cites W2798250834 @default.
• W4313503701 cites W2805145025 @default.
• W4313503701 cites W2898928807 @default.
• W4313503701 cites W2922047549 @default.
• W4313503701 cites W2989109767 @default.
• W4313503701 cites W2994916398 @default.
• W4313503701 cites W3024567240 @default.
• W4313503701 cites W3030321340 @default.
• W4313503701 cites W3141016314 @default.
• W4313503701 cites W3195243079 @default.
• W4313503701 cites W4247088117 @default.
• W4313503701 doi "https://doi.org/10.1007/s00262-022-03361-8" @default.
• W4313503701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36602564" @default.
• W4313503701 hasPublicationYear "2023" @default.
• W4313503701 type Work @default.
• W4313503701 citedByCount "0" @default.
• W4313503701 crossrefType "journal-article" @default.
• W4313503701 hasAuthorship W4313503701A5003219667 @default.
• W4313503701 hasAuthorship W4313503701A5011903306 @default.
• W4313503701 hasAuthorship W4313503701A5019784391 @default.
• W4313503701 hasAuthorship W4313503701A5022485574 @default.
• W4313503701 hasAuthorship W4313503701A5024339059 @default.
• W4313503701 hasAuthorship W4313503701A5026639675 @default.
• W4313503701 hasAuthorship W4313503701A5044473182 @default.
• W4313503701 hasAuthorship W4313503701A5055880996 @default.
• W4313503701 hasAuthorship W4313503701A5088896290 @default.
• W4313503701 hasBestOaLocation W43135037011 @default.
• W4313503701 hasConcept C121608353 @default.
• W4313503701 hasConcept C125418893 @default.
• W4313503701 hasConcept C126322002 @default.
• W4313503701 hasConcept C2777413986 @default.
• W4313503701 hasConcept C2777583451 @default.
• W4313503701 hasConcept C2778729363 @default.
• W4313503701 hasConcept C2778820342 @default.
• W4313503701 hasConcept C2779536868 @default.
• W4313503701 hasConcept C3019892230 @default.
• W4313503701 hasConcept C42362537 @default.
• W4313503701 hasConcept C502942594 @default.
• W4313503701 hasConcept C62478195 @default.
• W4313503701 hasConcept C71924100 @default.
• W4313503701 hasConcept C86803240 @default.
• W4313503701 hasConcept C95444343 @default.
• W4313503701 hasConcept C98274493 @default.
• W4313503701 hasConceptScore W4313503701C121608353 @default.
• W4313503701 hasConceptScore W4313503701C125418893 @default.
• W4313503701 hasConceptScore W4313503701C126322002 @default.
• W4313503701 hasConceptScore W4313503701C2777413986 @default.
• W4313503701 hasConceptScore W4313503701C2777583451 @default.
• W4313503701 hasConceptScore W4313503701C2778729363 @default.
• W4313503701 hasConceptScore W4313503701C2778820342 @default.

• next