Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313503801> ?p ?o ?g. }
- W4313503801 endingPage "974" @default.
- W4313503801 startingPage "974" @default.
- W4313503801 abstract "Standard treatments for gynecological cancers include surgery, chemotherapy, and radiation therapy. However, there are limitations associated with the chemotherapeutic drugs used to treat advanced and recurrent gynecological cancers, and it is difficult to identify additional treatments. Therefore, immune checkpoint inhibitor (ICI) therapy products, including PD-1/PD-L1 inhibitors and CTLA-4 inhibitors, are in the spotlight as alternatives for the treatment of advanced gynecological cancers. Although the ICI monotherapy response rate in gynecological cancers is lower than that in melanoma or non-small cell lung cancer, the response rates are approximately 13-52%, 7-22%, and 4-17% for endometrial, ovarian, and cervical cancers, respectively. Several studies are being conducted to compare the outcomes of combining ICI therapy with chemotherapy, radiation therapy, and antiangiogenesis agents. Therefore, it is critical to determine the mechanism underlying ICI therapy-mediated anti-tumor activity and its application in gynecological cancers. Additionally, understanding the possible immune-related adverse events induced post-immunotherapy, as well as the appropriate management of diagnosis and treatment, are necessary to create a quality environment for immunotherapy in patients with gynecological cancers. Therefore, in this review, we summarize the ICI mechanisms, ICIs applied to gynecological cancers, and appropriate diagnosis and treatment of immune-related side effects to help gynecologists treat gynecological cancers using immunotherapy." @default.
- W4313503801 created "2023-01-06" @default.
- W4313503801 creator A5032356605 @default.
- W4313503801 creator A5054962164 @default.
- W4313503801 creator A5062821586 @default.
- W4313503801 creator A5062938187 @default.
- W4313503801 creator A5072456286 @default.
- W4313503801 creator A5074128812 @default.
- W4313503801 creator A5074314211 @default.
- W4313503801 creator A5080843678 @default.
- W4313503801 date "2023-01-04" @default.
- W4313503801 modified "2023-09-26" @default.
- W4313503801 title "Application of Immune Checkpoint Inhibitors in Gynecological Cancers: What Do Gynecologists Need to Know before Using Immune Checkpoint Inhibitors?" @default.
- W4313503801 cites W1940241680 @default.
- W4313503801 cites W1942357581 @default.
- W4313503801 cites W1982488143 @default.
- W4313503801 cites W1992987036 @default.
- W4313503801 cites W2015085911 @default.
- W4313503801 cites W2022430110 @default.
- W4313503801 cites W2056535502 @default.
- W4313503801 cites W2060189730 @default.
- W4313503801 cites W2086397613 @default.
- W4313503801 cites W2099560139 @default.
- W4313503801 cites W2101653483 @default.
- W4313503801 cites W2105459360 @default.
- W4313503801 cites W2112121482 @default.
- W4313503801 cites W2127043059 @default.
- W4313503801 cites W2127446775 @default.
- W4313503801 cites W2128780762 @default.
- W4313503801 cites W2131640081 @default.
- W4313503801 cites W2135175382 @default.
- W4313503801 cites W2137074525 @default.
- W4313503801 cites W2147622445 @default.
- W4313503801 cites W2150678612 @default.
- W4313503801 cites W2152980179 @default.
- W4313503801 cites W2166107256 @default.
- W4313503801 cites W2280856093 @default.
- W4313503801 cites W2329871425 @default.
- W4313503801 cites W2336279251 @default.
- W4313503801 cites W2338423971 @default.
- W4313503801 cites W2416888735 @default.
- W4313503801 cites W2428806539 @default.
- W4313503801 cites W2466250207 @default.
- W4313503801 cites W2481467115 @default.
- W4313503801 cites W2502471875 @default.
- W4313503801 cites W2509217584 @default.
- W4313503801 cites W2522337762 @default.
- W4313503801 cites W2547133566 @default.
- W4313503801 cites W2560367415 @default.
- W4313503801 cites W2561156916 @default.
- W4313503801 cites W2572174216 @default.
- W4313503801 cites W2577007969 @default.
- W4313503801 cites W2586675028 @default.
- W4313503801 cites W2588362428 @default.
- W4313503801 cites W2595182131 @default.
- W4313503801 cites W2601055810 @default.
- W4313503801 cites W2612419201 @default.
- W4313503801 cites W2613745448 @default.
- W4313503801 cites W2618629077 @default.
- W4313503801 cites W2619461121 @default.
- W4313503801 cites W2676820279 @default.
- W4313503801 cites W2735587933 @default.
- W4313503801 cites W2740572218 @default.
- W4313503801 cites W2741725982 @default.
- W4313503801 cites W2743307239 @default.
- W4313503801 cites W2745126191 @default.
- W4313503801 cites W2747016053 @default.
- W4313503801 cites W2752549891 @default.
- W4313503801 cites W2760410509 @default.
- W4313503801 cites W2766016099 @default.
- W4313503801 cites W2766806972 @default.
- W4313503801 cites W2768429453 @default.
- W4313503801 cites W2768499948 @default.
- W4313503801 cites W2770798942 @default.
- W4313503801 cites W2783470345 @default.
- W4313503801 cites W2789201876 @default.
- W4313503801 cites W2886247697 @default.
- W4313503801 cites W2888408613 @default.
- W4313503801 cites W2889634032 @default.
- W4313503801 cites W2890261294 @default.
- W4313503801 cites W2891081107 @default.
- W4313503801 cites W2891267398 @default.
- W4313503801 cites W2891618702 @default.
- W4313503801 cites W2892335423 @default.
- W4313503801 cites W2898374755 @default.
- W4313503801 cites W2899728718 @default.
- W4313503801 cites W2901290947 @default.
- W4313503801 cites W2908431216 @default.
- W4313503801 cites W2914209924 @default.
- W4313503801 cites W2925815206 @default.
- W4313503801 cites W2942123458 @default.
- W4313503801 cites W2943887705 @default.
- W4313503801 cites W2946700293 @default.
- W4313503801 cites W2947605028 @default.
- W4313503801 cites W2954523357 @default.
- W4313503801 cites W2972117663 @default.
- W4313503801 cites W3000736809 @default.
- W4313503801 cites W3014698276 @default.