FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313503858> ?p ?o ?g. }

• W4313503858 endingPage "766" @default.
• W4313503858 startingPage "758" @default.
• W4313503858 abstract "Objectives There have been sporadic reports of ischemic spinal cord injury (SCI) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support. The authors observed a troubling pattern of this catastrophic complication and evaluated the potential mechanisms of SCI related to ECMO. Design This study was a case series. Setting This study was performed at a single institution in a University setting. Participants Patients requiring prolonged VA-ECMO were included. Interventions No interventions were done. This was an observational study. Measurements and Main Results Four hypotheses of etiology were considered: (1) hypercoagulable state/thromboembolism, (2) regional hypoxia/hypocarbia, (3) hyperperfusion and spinal cord edema, and (4) mechanical coverage of spinal arteries. The SCI involved the lower thoracic (T7-T12 level) spinal cord to the cauda equina in all patients. Seven out of 132 (5.3%) patients with prolonged VA-ECMO support developed SCI. The median time from ECMO cannulation to SCI was 7 (range: 6-17) days.There was no evidence of embolic SCI or extended regional hypoxia or hypocarbia. A unilateral, internal iliac artery was covered by the arterial cannula in 6/7 86%) patients, but flow into the internal iliac was demonstrated on imaging in all available patients. The median total flow (ECMO + intrinsic cardiac output) was 8.5 L/min (LPM), and indexed flow was 4.1 LPM/m2. The median central venous oxygen saturation was 88%, and intracranial pressure was measured at 30 mmHg in one patient, suggestive of hyperperfusion and spinal cord edema. Conclusions An SCI is a serious complication of extended peripheral VA-ECMO support. Its etiology remains uncertain, but the authors’ preliminary data suggested that spinal cord edema from hyperperfusion or venous congestion could contribute. There have been sporadic reports of ischemic spinal cord injury (SCI) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support. The authors observed a troubling pattern of this catastrophic complication and evaluated the potential mechanisms of SCI related to ECMO. This study was a case series. This study was performed at a single institution in a University setting. Patients requiring prolonged VA-ECMO were included. No interventions were done. This was an observational study. Four hypotheses of etiology were considered: (1) hypercoagulable state/thromboembolism, (2) regional hypoxia/hypocarbia, (3) hyperperfusion and spinal cord edema, and (4) mechanical coverage of spinal arteries. The SCI involved the lower thoracic (T7-T12 level) spinal cord to the cauda equina in all patients. Seven out of 132 (5.3%) patients with prolonged VA-ECMO support developed SCI. The median time from ECMO cannulation to SCI was 7 (range: 6-17) days.There was no evidence of embolic SCI or extended regional hypoxia or hypocarbia. A unilateral, internal iliac artery was covered by the arterial cannula in 6/7 86%) patients, but flow into the internal iliac was demonstrated on imaging in all available patients. The median total flow (ECMO + intrinsic cardiac output) was 8.5 L/min (LPM), and indexed flow was 4.1 LPM/m2. The median central venous oxygen saturation was 88%, and intracranial pressure was measured at 30 mmHg in one patient, suggestive of hyperperfusion and spinal cord edema. An SCI is a serious complication of extended peripheral VA-ECMO support. Its etiology remains uncertain, but the authors’ preliminary data suggested that spinal cord edema from hyperperfusion or venous congestion could contribute." @default.
• W4313503858 created "2023-01-06" @default.
• W4313503858 creator A5007107335 @default.
• W4313503858 creator A5021924520 @default.
• W4313503858 creator A5031977358 @default.
• W4313503858 creator A5032942555 @default.
• W4313503858 creator A5037676702 @default.
• W4313503858 creator A5038348270 @default.
• W4313503858 creator A5045274131 @default.
• W4313503858 creator A5045767890 @default.
• W4313503858 creator A5047931192 @default.
• W4313503858 creator A5057799551 @default.
• W4313503858 creator A5058363405 @default.
• W4313503858 creator A5066696989 @default.
• W4313503858 creator A5071462547 @default.
• W4313503858 creator A5071859357 @default.
• W4313503858 creator A5084238918 @default.
• W4313503858 creator A5086949606 @default.
• W4313503858 date "2023-05-01" @default.
• W4313503858 modified "2023-09-28" @default.
• W4313503858 title "Spinal Cord Infarction With Prolonged Femoral Venoarterial Extracorporeal Membrane Oxygenation" @default.
• W4313503858 cites W1254642044 @default.
• W4313503858 cites W18863746 @default.
• W4313503858 cites W2035859091 @default.
• W4313503858 cites W2138821274 @default.
• W4313503858 cites W2151901292 @default.
• W4313503858 cites W2295367239 @default.
• W4313503858 cites W2332675736 @default.
• W4313503858 cites W2529606187 @default.
• W4313503858 cites W2530295703 @default.
• W4313503858 cites W2588599139 @default.
• W4313503858 cites W2614814517 @default.
• W4313503858 cites W2755584350 @default.
• W4313503858 cites W2769737736 @default.
• W4313503858 cites W2796117989 @default.
• W4313503858 cites W2802764288 @default.
• W4313503858 cites W2803621368 @default.
• W4313503858 cites W2883572461 @default.
• W4313503858 cites W2890776174 @default.
• W4313503858 cites W2902995602 @default.
• W4313503858 cites W2914077820 @default.
• W4313503858 cites W2951589793 @default.
• W4313503858 cites W2992022833 @default.
• W4313503858 doi "https://doi.org/10.1053/j.jvca.2022.12.025" @default.
• W4313503858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36842938" @default.
• W4313503858 hasPublicationYear "2023" @default.
• W4313503858 type Work @default.
• W4313503858 citedByCount "0" @default.
• W4313503858 crossrefType "journal-article" @default.
• W4313503858 hasAuthorship W4313503858A5007107335 @default.
• W4313503858 hasAuthorship W4313503858A5021924520 @default.
• W4313503858 hasAuthorship W4313503858A5031977358 @default.
• W4313503858 hasAuthorship W4313503858A5032942555 @default.
• W4313503858 hasAuthorship W4313503858A5037676702 @default.
• W4313503858 hasAuthorship W4313503858A5038348270 @default.
• W4313503858 hasAuthorship W4313503858A5045274131 @default.
• W4313503858 hasAuthorship W4313503858A5045767890 @default.
• W4313503858 hasAuthorship W4313503858A5047931192 @default.
• W4313503858 hasAuthorship W4313503858A5057799551 @default.
• W4313503858 hasAuthorship W4313503858A5058363405 @default.
• W4313503858 hasAuthorship W4313503858A5066696989 @default.
• W4313503858 hasAuthorship W4313503858A5071462547 @default.
• W4313503858 hasAuthorship W4313503858A5071859357 @default.
• W4313503858 hasAuthorship W4313503858A5084238918 @default.
• W4313503858 hasAuthorship W4313503858A5086949606 @default.
• W4313503858 hasConcept C118552586 @default.
• W4313503858 hasConcept C141071460 @default.
• W4313503858 hasConcept C164705383 @default.
• W4313503858 hasConcept C2776858399 @default.
• W4313503858 hasConcept C2778334475 @default.
• W4313503858 hasConcept C2780775167 @default.
• W4313503858 hasConcept C42219234 @default.
• W4313503858 hasConcept C71924100 @default.
• W4313503858 hasConcept C81182388 @default.
• W4313503858 hasConceptScore W4313503858C118552586 @default.
• W4313503858 hasConceptScore W4313503858C141071460 @default.
• W4313503858 hasConceptScore W4313503858C164705383 @default.
• W4313503858 hasConceptScore W4313503858C2776858399 @default.
• W4313503858 hasConceptScore W4313503858C2778334475 @default.
• W4313503858 hasConceptScore W4313503858C2780775167 @default.
• W4313503858 hasConceptScore W4313503858C42219234 @default.
• W4313503858 hasConceptScore W4313503858C71924100 @default.
• W4313503858 hasConceptScore W4313503858C81182388 @default.
• W4313503858 hasIssue "5" @default.
• W4313503858 hasLocation W43135038581 @default.
• W4313503858 hasLocation W43135038582 @default.
• W4313503858 hasOpenAccess W4313503858 @default.
• W4313503858 hasPrimaryLocation W43135038581 @default.
• W4313503858 hasRelatedWork W2003938723 @default.
• W4313503858 hasRelatedWork W2047967234 @default.
• W4313503858 hasRelatedWork W2118496982 @default.
• W4313503858 hasRelatedWork W2369768841 @default.
• W4313503858 hasRelatedWork W2439875401 @default.
• W4313503858 hasRelatedWork W2469559411 @default.
• W4313503858 hasRelatedWork W4238867864 @default.
• W4313503858 hasRelatedWork W4379790954 @default.
• W4313503858 hasRelatedWork W1777239160 @default.
• W4313503858 hasRelatedWork W2525756941 @default.

• next