Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313504006> ?p ?o ?g. }
- W4313504006 endingPage "137053" @default.
- W4313504006 startingPage "137053" @default.
- W4313504006 abstract "Tramadol is one of the most commonly prescribed analgesic opioids in various pharmacopeias. Tramadol has been linked to abuse in recent clinical investigations. However, the behavioral effects and neural substrates of the drug have not been well characterized in preclinical studies. As a result, the present study investigated the effects of tramadol on behavioral sensitizations in rats. Its impacts on cellular and molecular alterations in the brain were also investigated. In conditioned place preference (CPP) paradigm, tramadol induced behavioral as well as motor sensitizations. These effects were dramatically reduced by intraperitoneal administration of naltrexone, an opioid receptor antagonist. Tramadol caused changes in several molecular markers (pERK1/2, Δ-FosB, PKCγ, PKMζ GAD67) in the anterior cingulate cortex, which could indicate an increase in excitation within this structure. Tramadol is demonstrated in the present study to be a reinforcing drug in rats, as it increased both behavioral and motor sensitizations. Tramadol's effects are most likely due to the high levels of excitation it causes in the brain, which is mostly caused by the activation of opioid receptors." @default.
- W4313504006 created "2023-01-06" @default.
- W4313504006 creator A5016447831 @default.
- W4313504006 creator A5021889273 @default.
- W4313504006 creator A5022007925 @default.
- W4313504006 creator A5058948419 @default.
- W4313504006 creator A5086865551 @default.
- W4313504006 date "2023-02-01" @default.
- W4313504006 modified "2023-09-30" @default.
- W4313504006 title "Reinforcing effect of tramadol in the rat" @default.
- W4313504006 cites W1487599137 @default.
- W4313504006 cites W154099657 @default.
- W4313504006 cites W1959245327 @default.
- W4313504006 cites W1964148806 @default.
- W4313504006 cites W1964851569 @default.
- W4313504006 cites W1968037117 @default.
- W4313504006 cites W1971011609 @default.
- W4313504006 cites W1972357528 @default.
- W4313504006 cites W1977858876 @default.
- W4313504006 cites W1990921850 @default.
- W4313504006 cites W2001197074 @default.
- W4313504006 cites W2003382388 @default.
- W4313504006 cites W2007187948 @default.
- W4313504006 cites W2007440728 @default.
- W4313504006 cites W2013510904 @default.
- W4313504006 cites W2015667857 @default.
- W4313504006 cites W2018682196 @default.
- W4313504006 cites W2021469789 @default.
- W4313504006 cites W2021895690 @default.
- W4313504006 cites W2024768412 @default.
- W4313504006 cites W2025930938 @default.
- W4313504006 cites W2028149881 @default.
- W4313504006 cites W2029196323 @default.
- W4313504006 cites W2030495291 @default.
- W4313504006 cites W2032788689 @default.
- W4313504006 cites W2033226513 @default.
- W4313504006 cites W2040435384 @default.
- W4313504006 cites W2040670788 @default.
- W4313504006 cites W2040764855 @default.
- W4313504006 cites W2042672129 @default.
- W4313504006 cites W2047787816 @default.
- W4313504006 cites W2049933206 @default.
- W4313504006 cites W2056357904 @default.
- W4313504006 cites W2064348459 @default.
- W4313504006 cites W2065605686 @default.
- W4313504006 cites W2066666299 @default.
- W4313504006 cites W2067530334 @default.
- W4313504006 cites W2069010931 @default.
- W4313504006 cites W2070448722 @default.
- W4313504006 cites W2071661571 @default.
- W4313504006 cites W2072402331 @default.
- W4313504006 cites W2080190361 @default.
- W4313504006 cites W2085537434 @default.
- W4313504006 cites W2085556169 @default.
- W4313504006 cites W2086917179 @default.
- W4313504006 cites W2087812264 @default.
- W4313504006 cites W2095302829 @default.
- W4313504006 cites W2106862702 @default.
- W4313504006 cites W2106867389 @default.
- W4313504006 cites W2123572460 @default.
- W4313504006 cites W2124732418 @default.
- W4313504006 cites W2124898317 @default.
- W4313504006 cites W2125750053 @default.
- W4313504006 cites W2125897488 @default.
- W4313504006 cites W2128772188 @default.
- W4313504006 cites W2140257707 @default.
- W4313504006 cites W2148943593 @default.
- W4313504006 cites W2152820601 @default.
- W4313504006 cites W2157406381 @default.
- W4313504006 cites W2158995449 @default.
- W4313504006 cites W2161234653 @default.
- W4313504006 cites W2162811260 @default.
- W4313504006 cites W2257665898 @default.
- W4313504006 cites W2426802935 @default.
- W4313504006 cites W2520800626 @default.
- W4313504006 cites W2755874335 @default.
- W4313504006 cites W2776827136 @default.
- W4313504006 cites W2903662406 @default.
- W4313504006 cites W2911034941 @default.
- W4313504006 cites W2972171608 @default.
- W4313504006 cites W2984885551 @default.
- W4313504006 cites W3010834529 @default.
- W4313504006 cites W3212631762 @default.
- W4313504006 doi "https://doi.org/10.1016/j.neulet.2023.137053" @default.
- W4313504006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36621588" @default.
- W4313504006 hasPublicationYear "2023" @default.
- W4313504006 type Work @default.
- W4313504006 citedByCount "0" @default.
- W4313504006 crossrefType "journal-article" @default.
- W4313504006 hasAuthorship W4313504006A5016447831 @default.
- W4313504006 hasAuthorship W4313504006A5021889273 @default.
- W4313504006 hasAuthorship W4313504006A5022007925 @default.
- W4313504006 hasAuthorship W4313504006A5058948419 @default.
- W4313504006 hasAuthorship W4313504006A5086865551 @default.
- W4313504006 hasConcept C126322002 @default.
- W4313504006 hasConcept C170493617 @default.
- W4313504006 hasConcept C2775962371 @default.
- W4313504006 hasConcept C2777389121 @default.