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- W4313506172 abstract "Cells constantly respond to environmental changes by modulating gene expression programs. These responses may demand substantial costs and, thus, affect cell growth. Understanding the regulation of these processes represents a key question in biology and biotechnology. Here, we studied the responses to osmotic stress in glucose-limited environments. By analyzing seventeen osmotic stress-induced genes and stress-activated protein kinase Hog1, we found that cells exhibited stronger osmotic gene expression response and larger integral of Hog1 nuclear localization during adaptation to osmotic stress under glucose-limited conditions than under glucose-rich conditions. We proposed and verified that in glucose-limited environment, glycolysis intermediates (representing reserve flux) were limited, which required cells to express more glycerol-production enzymes for stress adaptation. Consequently, the regulatory mechanism of osmoresponse was derived in the presence and absence of such reserve flux. Further experiments suggested that this reserve flux-dependent stress-defense strategy may be a general principle under nutrient-limited environments." @default.
- W4313506172 created "2023-01-06" @default.
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- W4313506172 date "2023-01-01" @default.
- W4313506172 modified "2023-10-14" @default.
- W4313506172 title "The regulatory mechanism of the yeast osmoresponse under different glucose concentrations" @default.
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- W4313506172 doi "https://doi.org/10.1016/j.isci.2022.105809" @default.
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