Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313506327> ?p ?o ?g. }
- W4313506327 abstract "The emergence of SARS-CoV-2 variants with highly mutated spike proteins has presented an obstacle to the use of monoclonal antibodies for the prevention and treatment of SARS-CoV-2 infection. We show that a high affinity receptor decoy protein in which a modified ACE2 ectodomain is fused to a single domain of an immunoglobulin heavy chain Fc region dramatically suppressed virus loads in mice upon challenge with a high dose of parental SARS-CoV-2 or Omicron variants. The decoy also potently suppressed virus replication when administered shortly post-infection. The decoy approach offers protection against the current viral variants and, potentially, against SARS-CoV-2 variants that may emerge with the continued evolution of the spike protein or novel viruses that use ACE2 for virus entry." @default.
- W4313506327 created "2023-01-06" @default.
- W4313506327 creator A5003118681 @default.
- W4313506327 creator A5033086866 @default.
- W4313506327 creator A5036106449 @default.
- W4313506327 creator A5059370302 @default.
- W4313506327 date "2023-01-02" @default.
- W4313506327 modified "2023-09-30" @default.
- W4313506327 title "Prophylaxis and Treatment of SARS-CoV-2 infection by an ACE2 Receptor Decoy" @default.
- W4313506327 cites W1928433960 @default.
- W4313506327 cites W1970942128 @default.
- W4313506327 cites W1991539551 @default.
- W4313506327 cites W2019010081 @default.
- W4313506327 cites W2051738649 @default.
- W4313506327 cites W2071843728 @default.
- W4313506327 cites W2073383703 @default.
- W4313506327 cites W2093009072 @default.
- W4313506327 cites W2103302581 @default.
- W4313506327 cites W2129482327 @default.
- W4313506327 cites W2133017175 @default.
- W4313506327 cites W2141247392 @default.
- W4313506327 cites W3021880084 @default.
- W4313506327 cites W3023711031 @default.
- W4313506327 cites W3047003416 @default.
- W4313506327 cites W3048714202 @default.
- W4313506327 cites W3092503590 @default.
- W4313506327 cites W3096064145 @default.
- W4313506327 cites W3102798166 @default.
- W4313506327 cites W3104722250 @default.
- W4313506327 cites W3109052585 @default.
- W4313506327 cites W3111431752 @default.
- W4313506327 cites W3115009914 @default.
- W4313506327 cites W3164220019 @default.
- W4313506327 cites W3164250739 @default.
- W4313506327 cites W3164611210 @default.
- W4313506327 cites W3175562186 @default.
- W4313506327 cites W3176022402 @default.
- W4313506327 cites W3198860035 @default.
- W4313506327 cites W3199620752 @default.
- W4313506327 cites W3208693108 @default.
- W4313506327 cites W4200121261 @default.
- W4313506327 cites W4200147052 @default.
- W4313506327 cites W4200351794 @default.
- W4313506327 cites W4200374450 @default.
- W4313506327 cites W4200509137 @default.
- W4313506327 cites W4200559561 @default.
- W4313506327 cites W4206135665 @default.
- W4313506327 cites W4220718129 @default.
- W4313506327 cites W4220886953 @default.
- W4313506327 cites W4220904663 @default.
- W4313506327 cites W4224921393 @default.
- W4313506327 cites W4225312017 @default.
- W4313506327 cites W4225647476 @default.
- W4313506327 cites W4226246149 @default.
- W4313506327 cites W4283026725 @default.
- W4313506327 cites W4283160598 @default.
- W4313506327 cites W4313456694 @default.
- W4313506327 doi "https://doi.org/10.1101/2022.12.31.522401" @default.
- W4313506327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36656772" @default.
- W4313506327 hasPublicationYear "2023" @default.
- W4313506327 type Work @default.
- W4313506327 citedByCount "1" @default.
- W4313506327 countsByYear W43135063272023 @default.
- W4313506327 crossrefType "posted-content" @default.
- W4313506327 hasAuthorship W4313506327A5003118681 @default.
- W4313506327 hasAuthorship W4313506327A5033086866 @default.
- W4313506327 hasAuthorship W4313506327A5036106449 @default.
- W4313506327 hasAuthorship W4313506327A5059370302 @default.
- W4313506327 hasBestOaLocation W43135063271 @default.
- W4313506327 hasConcept C1009742 @default.
- W4313506327 hasConcept C140704245 @default.
- W4313506327 hasConcept C142724271 @default.
- W4313506327 hasConcept C159047783 @default.
- W4313506327 hasConcept C159654299 @default.
- W4313506327 hasConcept C170493617 @default.
- W4313506327 hasConcept C203014093 @default.
- W4313506327 hasConcept C2522874641 @default.
- W4313506327 hasConcept C2777648638 @default.
- W4313506327 hasConcept C2779134260 @default.
- W4313506327 hasConcept C2779179475 @default.
- W4313506327 hasConcept C2993512173 @default.
- W4313506327 hasConcept C3007834351 @default.
- W4313506327 hasConcept C3008058167 @default.
- W4313506327 hasConcept C3020491458 @default.
- W4313506327 hasConcept C524204448 @default.
- W4313506327 hasConcept C542903549 @default.
- W4313506327 hasConcept C54355233 @default.
- W4313506327 hasConcept C58475186 @default.
- W4313506327 hasConcept C71924100 @default.
- W4313506327 hasConcept C86803240 @default.
- W4313506327 hasConceptScore W4313506327C1009742 @default.
- W4313506327 hasConceptScore W4313506327C140704245 @default.
- W4313506327 hasConceptScore W4313506327C142724271 @default.
- W4313506327 hasConceptScore W4313506327C159047783 @default.
- W4313506327 hasConceptScore W4313506327C159654299 @default.
- W4313506327 hasConceptScore W4313506327C170493617 @default.
- W4313506327 hasConceptScore W4313506327C203014093 @default.
- W4313506327 hasConceptScore W4313506327C2522874641 @default.
- W4313506327 hasConceptScore W4313506327C2777648638 @default.
- W4313506327 hasConceptScore W4313506327C2779134260 @default.