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- W4313506654 abstract "Broad spectrum amino acid racemases (Bsrs) aid bacteria in producing non-canonical D-amino acids (NCDAA), which play significant functions in the modification of cell walls and biofilm breakdown. Bsr reversibly racemizes 10 of the 19 naturally occurring chiral amino acids (AAs), like both non-branching aliphatic AAs and positively charged amino acids, contrary to monospecific racemases. Additionally, it helps in racemization reactions involving AAs which are not characteristically incorporated into proteins. The substrate range of Bsr is wide-ranging in comparison to other known amino-acid racemases suggesting its tremendous potential for biotechnological and industrial applications. Furthermore, since it was discovered that many taxonomically unrelated bacteria can discharge massive amounts of D-amino acids (D-AAs) into the environment, D-AAs has become a popular area in microbial research. The obtainability of D-AAs might influence microbial evolution, altering the diversity and longevity of organisms in niches. The finding of this family of Bsr has further made researchers focus on the impact of discovering the presence of new multi-specific enzymes in nature. This chapter explores the properties of Bsr that makes it a potential candidate for research because of its immense potential in biotechnology. This chapter follows in silico tools to unravel the significance of Bsr in Vibrio cholerae (BsrV)." @default.
- W4313506654 created "2023-01-06" @default.
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- W4313506654 date "2023-01-01" @default.
- W4313506654 modified "2023-09-27" @default.
- W4313506654 title "Broad Spectrum Amino Acid Racemases (Bsrs): A Potential Target in Microbial Research" @default.
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- W4313506654 doi "https://doi.org/10.1007/978-981-19-4336-2_18" @default.
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