Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313508350> ?p ?o ?g. }
- W4313508350 endingPage "32" @default.
- W4313508350 startingPage "32" @default.
- W4313508350 abstract "To complete their replication cycle, retroviruses need to integrate a DNA copy of their RNA genome into a host chromosome. Integration site selection is not random and is driven by multiple viral and cellular host factors specific to different classes of retroviruses. Today, overwhelming evidence from cell culture, animal experiments and clinical data suggests that integration sites are important for retroviral replication, oncogenesis and/or latency. In this review, we will summarize the increasing knowledge of the mechanisms underlying the integration site selection of the gammaretrovirus MLV and the lentivirus HIV-1. We will discuss how host factors of the integration site selection of retroviruses may steer the development of safer viral vectors for gene therapy. Next, we will discuss how altering the integration site preference of HIV-1 using small molecules could lead to a cure for HIV-1 infection." @default.
- W4313508350 created "2023-01-06" @default.
- W4313508350 creator A5018065960 @default.
- W4313508350 creator A5036165439 @default.
- W4313508350 creator A5044112097 @default.
- W4313508350 creator A5068792719 @default.
- W4313508350 date "2022-12-21" @default.
- W4313508350 modified "2023-10-18" @default.
- W4313508350 title "Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection" @default.
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