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- W4313522014 abstract "Abstract Background Tumor-adjacent benign mammary epithelium and myoepithelium can play a pivotal role in tumor growth and progression. We investigated the invasive behavior of patient-derived microtumors and breast cancer cell line-derived spheroids in co-culture with induced pluripotent stem cell-derived mammary-like organoids in an autologous and allogenic manner. This co-culture systems enables a better understanding of the tumor-promoting function of the benign mammary (myo-) epithelium in different types of breast cancers. Methods Using three-dimensional co-culture settings of induced pluripotent stem cell-derived mammary-like organoids and patient-derived microtumors or cancer cell line-derived spheroids, we investigated tumor growth and invasiveness of the cancers by using imaging-based analysis. Levels of Fibronectin and Metalloproteinase-2 in co-cultures and respective mono-cultures were measured using multiplexed Luminex assay. Results We observed significant increases in growth and invasiveness of invasive ductal carcinoma of no special type patient-derived microtumors in co-culture with induced pluripotent stem cell-derived mammary-like organoids. We identified upregulations of the prognostic markers Fibronectin and Metalloproteinase-2 in all co-cultures compared to respective mono-cultures of mammary-like organoids, patient-derived microtumors and cell line-derived spheroids. Conclusions These findings indicate a tumor-promoting role of the tumor-adjacent mammary (myo-) epithelium dependent on the tumor composition and tumor stage. Our results highlight the importance of breast tumor models that closely resemble the heterogenous composition of primary breast tumors." @default.
- W4313522014 created "2023-01-06" @default.
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- W4313522014 date "2023-01-03" @default.
- W4313522014 modified "2023-10-03" @default.
- W4313522014 title "Co-cultures of iPSC-derived Mammary-like Organoids and Patient-derived Microtumors Model Invasive Behavior of Breast Cancer ex vivo" @default.
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- W4313522014 doi "https://doi.org/10.21203/rs.3.rs-2408179/v1" @default.
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