FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313522037> ?p ?o ?g. }

• W4313522037 abstract "Abstract Background Gender differences in bone metabolism of people with chronic obstructive pulmonary disease (COPD) remain unclear. We aim to explore the characteristics of bone metabolism and its clinical significance for patients with COPD. Methods A total of 564 cases (282 COPD cases and 282 controls) were preselected. Clinical and analytical characteristics of these cases were assessed. After excluding patients with other conditions known to disturb calcium metabolism, 333 patients (152 COPD cases and 181 controls) were identified. The medical records, indexes of bone turnover markers, serum calcium and phosphorus of the 333 patients were collected and their correlation was analyzed. Results The 152 cases with COPD were 82.61 ± 7.745 years, 78.3% males, and the 181 age- and sex-matched control cases were 79.73 ± 11.742 years, 72.4% males. Levels of total procollagen type I amino-terminal propeptide (tPINP), osteocalcin (OC), serum calcium and phosphate were significantly lower ( P < 0.001) while the level of parathormone (PTH) was significantly higher ( P = 0.004) in COPD than in controls. The 25-hydroxycholecalciferol (25(OH)D 3 ) was below the lower limit of normal value (LLN) in both groups, which was significantly lower in COPD males than in control males ( P = 0.026). In COPD group, PTH level was significantly higher in females ( P = 0.006), and serum P was lower in males ( P = 0.006). The adjusted linear regression analysis showed that the levels of tPINP, OC and serum Ca were decreasing greatly in COPD group [β (95%CI) − 8.958 (− 15.255 to − 2.662), P = 0.005; − 4.584 (− 6.627 to − 2.542), P < 0.001; − 0.065 (− 0.100 to − 0.031), P < 0.001]. Besides, smoke exposure, gender (male) were also related to hypocalcemia [β (95%CI) − 0.025 (− 0.045 to − 0.005), P = 0.017; − 0.041 (− 0.083 to − 0.001), P = 0.047], and 25(OH)D 3 was correlated with serum calcium, phosphorus, and PTH [β (95%CI) 15.392(7.032–23.753), P < 0.001; − 7.287 (− 13.450 to − 1.124), P = 0.021; − 0.103(− 0.145 to − 0.061), P < 0.001], and female was more likely to have secondary hyperparathyroidism [β (95%CI) 12.141 (4.047–20.235), P = 0.002]. Conclusion COPD patients have remarkably low bone turnover (indicated by OC) and impaired bone formation (low tPINP), and they are also more prone to low calcium. Smoking and male may play roles in the formation of hypocalcemia, and the secondary hyperparathyroidism is more significant in COPD women. There may be gender differences in bone metabolism abnormalities and their mechanisms of COPD. The conclusion above still need further research and demonstration." @default.
• W4313522037 created "2023-01-06" @default.
• W4313522037 creator A5011540763 @default.
• W4313522037 creator A5044845482 @default.
• W4313522037 creator A5049521464 @default.
• W4313522037 creator A5063756527 @default.
• W4313522037 creator A5072400260 @default.
• W4313522037 date "2023-01-03" @default.
• W4313522037 modified "2023-10-09" @default.
• W4313522037 title "Bone metabolism characteristics and gender differences in patients with COPD: a cross-sectional study" @default.
• W4313522037 cites W1499693260 @default.
• W4313522037 cites W1937064631 @default.
• W4313522037 cites W2043552188 @default.
• W4313522037 cites W2058225988 @default.
• W4313522037 cites W2060701395 @default.
• W4313522037 cites W2061450074 @default.
• W4313522037 cites W2078906832 @default.
• W4313522037 cites W2092479752 @default.
• W4313522037 cites W2100607777 @default.
• W4313522037 cites W2123346255 @default.
• W4313522037 cites W2136873648 @default.
• W4313522037 cites W2529169464 @default.
• W4313522037 cites W2560236746 @default.
• W4313522037 cites W2766310128 @default.
• W4313522037 cites W2909497687 @default.
• W4313522037 cites W2916470714 @default.
• W4313522037 cites W2997777654 @default.
• W4313522037 cites W3158806460 @default.
• W4313522037 cites W3176230826 @default.
• W4313522037 cites W4237443752 @default.
• W4313522037 doi "https://doi.org/10.1186/s12890-022-02298-z" @default.
• W4313522037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597085" @default.
• W4313522037 hasPublicationYear "2023" @default.
• W4313522037 type Work @default.
• W4313522037 citedByCount "1" @default.
• W4313522037 countsByYear W43135220372023 @default.
• W4313522037 crossrefType "journal-article" @default.
• W4313522037 hasAuthorship W4313522037A5011540763 @default.
• W4313522037 hasAuthorship W4313522037A5044845482 @default.
• W4313522037 hasAuthorship W4313522037A5049521464 @default.
• W4313522037 hasAuthorship W4313522037A5063756527 @default.
• W4313522037 hasAuthorship W4313522037A5072400260 @default.
• W4313522037 hasBestOaLocation W43135220371 @default.
• W4313522037 hasConcept C126322002 @default.
• W4313522037 hasConcept C131075544 @default.
• W4313522037 hasConcept C134018914 @default.
• W4313522037 hasConcept C142052008 @default.
• W4313522037 hasConcept C142724271 @default.
• W4313522037 hasConcept C160160445 @default.
• W4313522037 hasConcept C170033053 @default.
• W4313522037 hasConcept C181199279 @default.
• W4313522037 hasConcept C185592680 @default.
• W4313522037 hasConcept C2776780178 @default.
• W4313522037 hasConcept C55493867 @default.
• W4313522037 hasConcept C63363279 @default.
• W4313522037 hasConcept C64348721 @default.
• W4313522037 hasConcept C71924100 @default.
• W4313522037 hasConcept C90924648 @default.
• W4313522037 hasConceptScore W4313522037C126322002 @default.
• W4313522037 hasConceptScore W4313522037C131075544 @default.
• W4313522037 hasConceptScore W4313522037C134018914 @default.
• W4313522037 hasConceptScore W4313522037C142052008 @default.
• W4313522037 hasConceptScore W4313522037C142724271 @default.
• W4313522037 hasConceptScore W4313522037C160160445 @default.
• W4313522037 hasConceptScore W4313522037C170033053 @default.
• W4313522037 hasConceptScore W4313522037C181199279 @default.
• W4313522037 hasConceptScore W4313522037C185592680 @default.
• W4313522037 hasConceptScore W4313522037C2776780178 @default.
• W4313522037 hasConceptScore W4313522037C55493867 @default.
• W4313522037 hasConceptScore W4313522037C63363279 @default.
• W4313522037 hasConceptScore W4313522037C64348721 @default.
• W4313522037 hasConceptScore W4313522037C71924100 @default.
• W4313522037 hasConceptScore W4313522037C90924648 @default.
• W4313522037 hasIssue "1" @default.
• W4313522037 hasLocation W43135220371 @default.
• W4313522037 hasLocation W43135220372 @default.
• W4313522037 hasLocation W43135220373 @default.
• W4313522037 hasOpenAccess W4313522037 @default.
• W4313522037 hasPrimaryLocation W43135220371 @default.
• W4313522037 hasRelatedWork W1967422973 @default.
• W4313522037 hasRelatedWork W2020299418 @default.
• W4313522037 hasRelatedWork W2022695623 @default.
• W4313522037 hasRelatedWork W2036148628 @default.
• W4313522037 hasRelatedWork W2041938128 @default.
• W4313522037 hasRelatedWork W2128714854 @default.
• W4313522037 hasRelatedWork W2155593667 @default.
• W4313522037 hasRelatedWork W2157209565 @default.
• W4313522037 hasRelatedWork W2160818938 @default.
• W4313522037 hasRelatedWork W2166752210 @default.
• W4313522037 hasVolume "23" @default.
• W4313522037 isParatext "false" @default.
• W4313522037 isRetracted "false" @default.
• W4313522037 workType "article" @default.