Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313522046> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4313522046 abstract "Abstract Background Decreased eosinophil level was associated with poor outcome after mechanical thrombectomy in patients with acute ischemic stroke (AIS), but pathogenesis of this association is elusive. We aimed to assess the mediation effect of intracranial bleeding complications on the aforementioned association. Methods A total of three hundred and twenty-eight consecutive AIS patients experiencing mechanical thrombectomy between May 2017 and March 2021 were analyzed. Hemorrhagic transformation (HT) were categorized as symptomatic intracranial hemorrhage (sICH) and parenchymal hematoma (PH) according to previously published criteria. Regression analysis was used to assess the effect of eosinophils on HT, and its effect on poor outcome. Mediation analysis was utilized to assess the proportion of total effect by HT on the association between eosinophils and poor outcome. Results Multivariater analysis revealed that eosinophils was independently associated with sICH after adjusting for potential confounders (odds ratio, 0.00; 95% CI, 0.00–0.01; P = 0.0141), which is consistent with the result of eosinophils (dichotomous) as a categorical variable (odds ratio, 0.22; 95% CI, 0.11–0.46; P < 0.0001). And the risk of PH in higher eosinophils was 0.36 fold higher than in patients in the low eosinophil group (OR, 0.36, 95% CI, 0.19–0.67; P = 0.0013). Eosinophils was negative associated with poor outcome (odds ratio, 0.00; 95% CI, 0.00–0.02; P = 0.0021). And mediation analysis found that sICH partially mediated the negative relationship between eosinophils and poor outcome (indirect effect=-0.1896; 95%CI: -0.3654 – -0.03, P < 0.001); however, PH did not mediate the association between eosinophils and poor outcome ( P = 0.12). Conclusion This study showed an important effect of sICH on the association between eosinophils and poor outcome." @default.
- W4313522046 created "2023-01-06" @default.
- W4313522046 creator A5003616974 @default.
- W4313522046 creator A5007966189 @default.
- W4313522046 creator A5017803389 @default.
- W4313522046 creator A5052488500 @default.
- W4313522046 creator A5077020482 @default.
- W4313522046 date "2023-01-03" @default.
- W4313522046 modified "2023-09-25" @default.
- W4313522046 title "Symptomatic intracranial hemorrhage mediates the association between eosinophils and 90-day outcomes after mechanical thrombectomy for acute ischemic stroke" @default.
- W4313522046 cites W2001620265 @default.
- W4313522046 cites W2098032054 @default.
- W4313522046 cites W2139719760 @default.
- W4313522046 cites W2155681330 @default.
- W4313522046 cites W2162891740 @default.
- W4313522046 cites W2193561325 @default.
- W4313522046 cites W2509037974 @default.
- W4313522046 cites W2604363348 @default.
- W4313522046 cites W2765564616 @default.
- W4313522046 cites W2767160803 @default.
- W4313522046 cites W2803254634 @default.
- W4313522046 cites W2897365154 @default.
- W4313522046 cites W2947165849 @default.
- W4313522046 cites W2984096386 @default.
- W4313522046 cites W2995105425 @default.
- W4313522046 cites W3015164483 @default.
- W4313522046 cites W3127422052 @default.
- W4313522046 cites W3182542493 @default.
- W4313522046 cites W3183975698 @default.
- W4313522046 cites W4206351522 @default.
- W4313522046 cites W4281286962 @default.
- W4313522046 cites W4281644595 @default.
- W4313522046 doi "https://doi.org/10.21203/rs.3.rs-2116708/v1" @default.
- W4313522046 hasPublicationYear "2023" @default.
- W4313522046 type Work @default.
- W4313522046 citedByCount "0" @default.
- W4313522046 crossrefType "posted-content" @default.
- W4313522046 hasAuthorship W4313522046A5003616974 @default.
- W4313522046 hasAuthorship W4313522046A5007966189 @default.
- W4313522046 hasAuthorship W4313522046A5017803389 @default.
- W4313522046 hasAuthorship W4313522046A5052488500 @default.
- W4313522046 hasAuthorship W4313522046A5077020482 @default.
- W4313522046 hasBestOaLocation W43135220461 @default.
- W4313522046 hasConcept C126322002 @default.
- W4313522046 hasConcept C127413603 @default.
- W4313522046 hasConcept C156957248 @default.
- W4313522046 hasConcept C2776042228 @default.
- W4313522046 hasConcept C2777037409 @default.
- W4313522046 hasConcept C2777736543 @default.
- W4313522046 hasConcept C2780645631 @default.
- W4313522046 hasConcept C71924100 @default.
- W4313522046 hasConcept C77350462 @default.
- W4313522046 hasConcept C78519656 @default.
- W4313522046 hasConcept C90924648 @default.
- W4313522046 hasConceptScore W4313522046C126322002 @default.
- W4313522046 hasConceptScore W4313522046C127413603 @default.
- W4313522046 hasConceptScore W4313522046C156957248 @default.
- W4313522046 hasConceptScore W4313522046C2776042228 @default.
- W4313522046 hasConceptScore W4313522046C2777037409 @default.
- W4313522046 hasConceptScore W4313522046C2777736543 @default.
- W4313522046 hasConceptScore W4313522046C2780645631 @default.
- W4313522046 hasConceptScore W4313522046C71924100 @default.
- W4313522046 hasConceptScore W4313522046C77350462 @default.
- W4313522046 hasConceptScore W4313522046C78519656 @default.
- W4313522046 hasConceptScore W4313522046C90924648 @default.
- W4313522046 hasLocation W43135220461 @default.
- W4313522046 hasOpenAccess W4313522046 @default.
- W4313522046 hasPrimaryLocation W43135220461 @default.
- W4313522046 hasRelatedWork W2036736708 @default.
- W4313522046 hasRelatedWork W2091800331 @default.
- W4313522046 hasRelatedWork W2133049159 @default.
- W4313522046 hasRelatedWork W2143394782 @default.
- W4313522046 hasRelatedWork W2313074380 @default.
- W4313522046 hasRelatedWork W2339958467 @default.
- W4313522046 hasRelatedWork W2387300907 @default.
- W4313522046 hasRelatedWork W2393810208 @default.
- W4313522046 hasRelatedWork W3039977083 @default.
- W4313522046 hasRelatedWork W4285389100 @default.
- W4313522046 isParatext "false" @default.
- W4313522046 isRetracted "false" @default.
- W4313522046 workType "article" @default.