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- W4313525700 abstract "De novo assembly, which discovers the entire nucleotide sequence by reconstructing the reads resulting from next-generation sequencing, is a subject that must be studied for genetic information analysis. The recombination of reads is performed in several steps, but gaps that cannot be resolved occur even after scaffolding. Gap-filling is performed as the last assembly stage to fill the unidentified regions called gaps, significantly improving overall assembly performance. We propose a gap-filling method using hybrid reads to resolve gaps based on sequence similarity estimation and graph searches. The proposed method consists of three key steps: extracting the candidate sequence, estimating similarity, and filling the gaps based on the graph. Hybrid reads extract sequences with more accurate information, and candidate sequences corresponding to noise are effectively removed based on the similarity estimation. In conclusion, a graph search using statistical information derives a final sequence that guarantees high coverage, resolves gaps, reduces misassemblies, and improves accuracy." @default.
- W4313525700 created "2023-01-06" @default.
- W4313525700 creator A5004070162 @default.
- W4313525700 creator A5040515246 @default.
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- W4313525700 date "2022-12-06" @default.
- W4313525700 modified "2023-10-17" @default.
- W4313525700 title "A Novel Gap-Filling Method Based on Hybrid Read Information Analysis" @default.
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- W4313525700 doi "https://doi.org/10.1109/bibm55620.2022.9994889" @default.
- W4313525700 hasPublicationYear "2022" @default.
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