Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313528746> ?p ?o ?g. }
- W4313528746 abstract "Abstract The roles of synonymous mutations for adapting to stressful thermal environments are of fundamental biological and ecological interests but poorly understood. To study whether synonymous mutations influence thermal adaptation at specific microhabitats, a genome-wide genotype-phenotype association analysis is carried out in the black mussels Mytilisepta virgata . A synonymous mutation of Ubiquitin-specific Peptidase 15 ( MvUSP15) is significantly associated with the physiological upper thermal limit. The individuals carrying GG genotype (the G-type) at the mutant locus possess significantly lower heat tolerance compared to the individuals carrying GA and AA genotypes (the A-type). When heated to sublethal temperature, the G-type exhibit higher inter-individual variations in MvUSP15 expression, especially for the mussels on the sun-exposed microhabitats. Taken together, a synonymous mutation in MvUSP15 can affect the gene expression profile and interact with microhabitat heterogeneity to influence thermal resistance. This integrative study sheds light on the ecological importance of adaptive synonymous mutations as an underappreciated genetic buffer against heat stress and emphasizes the importance of integrative studies at a microhabitat scale for evaluating and predicting the impacts of climate change." @default.
- W4313528746 created "2023-01-06" @default.
- W4313528746 creator A5066516649 @default.
- W4313528746 creator A5077875084 @default.
- W4313528746 creator A5082136392 @default.
- W4313528746 creator A5085050188 @default.
- W4313528746 creator A5085504980 @default.
- W4313528746 date "2023-01-03" @default.
- W4313528746 modified "2023-09-26" @default.
- W4313528746 title "Genome-wide sequencing identifies a thermal-tolerance related synonymous mutation in the mussel, Mytilisepta virgata" @default.
- W4313528746 cites W1502144390 @default.
- W4313528746 cites W1709815505 @default.
- W4313528746 cites W1821048630 @default.
- W4313528746 cites W1956613997 @default.
- W4313528746 cites W1971529589 @default.
- W4313528746 cites W1984068087 @default.
- W4313528746 cites W1984512854 @default.
- W4313528746 cites W1986133462 @default.
- W4313528746 cites W2000033060 @default.
- W4313528746 cites W2004945910 @default.
- W4313528746 cites W2005723624 @default.
- W4313528746 cites W2008047653 @default.
- W4313528746 cites W2008951609 @default.
- W4313528746 cites W2009818318 @default.
- W4313528746 cites W2023515240 @default.
- W4313528746 cites W2034837695 @default.
- W4313528746 cites W2057911323 @default.
- W4313528746 cites W2058864686 @default.
- W4313528746 cites W2060665205 @default.
- W4313528746 cites W2066829062 @default.
- W4313528746 cites W2094148055 @default.
- W4313528746 cites W2094338137 @default.
- W4313528746 cites W2100481775 @default.
- W4313528746 cites W2102795115 @default.
- W4313528746 cites W2103441770 @default.
- W4313528746 cites W2105654777 @default.
- W4313528746 cites W2107277218 @default.
- W4313528746 cites W2111940047 @default.
- W4313528746 cites W2115787060 @default.
- W4313528746 cites W2123900386 @default.
- W4313528746 cites W2129137649 @default.
- W4313528746 cites W2140679396 @default.
- W4313528746 cites W2160891704 @default.
- W4313528746 cites W2161633633 @default.
- W4313528746 cites W2168420558 @default.
- W4313528746 cites W2192080449 @default.
- W4313528746 cites W2209510499 @default.
- W4313528746 cites W2265677216 @default.
- W4313528746 cites W2282217134 @default.
- W4313528746 cites W2483612741 @default.
- W4313528746 cites W2501900207 @default.
- W4313528746 cites W2524169008 @default.
- W4313528746 cites W2610898989 @default.
- W4313528746 cites W2743560247 @default.
- W4313528746 cites W2746891755 @default.
- W4313528746 cites W2755331695 @default.
- W4313528746 cites W2762868004 @default.
- W4313528746 cites W2770010032 @default.
- W4313528746 cites W2791799569 @default.
- W4313528746 cites W2799524357 @default.
- W4313528746 cites W2803232199 @default.
- W4313528746 cites W2807308836 @default.
- W4313528746 cites W2885806542 @default.
- W4313528746 cites W2892663579 @default.
- W4313528746 cites W2943952349 @default.
- W4313528746 cites W2949423018 @default.
- W4313528746 cites W2950943638 @default.
- W4313528746 cites W2951912016 @default.
- W4313528746 cites W2952869842 @default.
- W4313528746 cites W2964301449 @default.
- W4313528746 cites W2970259886 @default.
- W4313528746 cites W2970263563 @default.
- W4313528746 cites W2976876706 @default.
- W4313528746 cites W3003032548 @default.
- W4313528746 cites W3014749308 @default.
- W4313528746 cites W3016788784 @default.
- W4313528746 cites W3016878994 @default.
- W4313528746 cites W3024024469 @default.
- W4313528746 cites W3032136839 @default.
- W4313528746 cites W3038202913 @default.
- W4313528746 cites W3089755549 @default.
- W4313528746 cites W3093868212 @default.
- W4313528746 cites W3128444636 @default.
- W4313528746 cites W3130641440 @default.
- W4313528746 cites W3131055609 @default.
- W4313528746 cites W3134706939 @default.
- W4313528746 cites W3148509073 @default.
- W4313528746 cites W3198279247 @default.
- W4313528746 cites W3198318700 @default.
- W4313528746 cites W3208566584 @default.
- W4313528746 cites W3211118334 @default.
- W4313528746 cites W3211437706 @default.
- W4313528746 cites W4200569725 @default.
- W4313528746 cites W4212910130 @default.
- W4313528746 cites W4247053599 @default.
- W4313528746 doi "https://doi.org/10.1038/s42003-022-04407-4" @default.
- W4313528746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36596992" @default.
- W4313528746 hasPublicationYear "2023" @default.
- W4313528746 type Work @default.
- W4313528746 citedByCount "0" @default.