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• W4313530025 endingPage "110392" @default.
• W4313530025 startingPage "110392" @default.
• W4313530025 abstract "The biological activities of 1,4-bis(o-aminobenzyl)-1,4-diazacycloheptane (L) and the copper(II) and nickel(II) complexes, [CuL](ClO4)2 and [Ni(L)(NCMe)2](ClO4)2. NCMe, were investigated. The X-ray structural analysis of the latter complex shows that the nickel(II) ion is in a slightly distorted octahedral coordination environment coordinated by four nitrogen atoms of the ligand with two molecules of acetonitrile in the trans configuration. The binding behavior of the ligand and corresponding Cu(II) and Ni(II) complexes with DNA and acetylcholinesterase (AChE) was investigated by molecular modeling. These studies indicated that the copper complex was bound to the major groove of DNA and polar and non-polar residues located in the active-site gorge (binding site of E2020) of AChE. The binding constants obtained from the molecular docking results showed a remarkably high affinity of the Cu(II) complex to both DNA and AChE compared to the ligand and the nickel(II) complex. Further investigations demonstrated that the synthesized complexes, especially [CuL](ClO4)2, had a strong ability to scavenge DPPH free radicals. The anticancer activity of the ligand and related complexes was also assessed, using the MTT test, which found that the highest activity was observed for [CuL](ClO4)2 against breast cancer (MCF-7) cells." @default.
• W4313530025 created "2023-01-06" @default.
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• W4313530025 creator A5063201642 @default.
• W4313530025 creator A5069032618 @default.
• W4313530025 creator A5073888395 @default.
• W4313530025 date "2023-03-01" @default.
• W4313530025 modified "2023-10-09" @default.
• W4313530025 title "Molecular docking and biological studies of the Cu(II) and Ni(II) macroacyclic complexes with 1,4-bis(o-aminobenzyl)-1,4-diazacycloheptane, a ligand containing the homopiperazine moiety" @default.
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• W4313530025 cites W1965978316 @default.
• W4313530025 cites W1969360633 @default.
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• W4313530025 cites W1986240377 @default.
• W4313530025 cites W1992399702 @default.
• W4313530025 cites W1998826744 @default.
• W4313530025 cites W2000276238 @default.
• W4313530025 cites W2014603380 @default.
• W4313530025 cites W2015155465 @default.
• W4313530025 cites W2016000773 @default.
• W4313530025 cites W2019584487 @default.
• W4313530025 cites W2030619273 @default.
• W4313530025 cites W2034239878 @default.
• W4313530025 cites W2047644345 @default.
• W4313530025 cites W2051339183 @default.
• W4313530025 cites W2053174787 @default.
• W4313530025 cites W2059205366 @default.
• W4313530025 cites W2059586689 @default.
• W4313530025 cites W2070642716 @default.
• W4313530025 cites W2075079592 @default.
• W4313530025 cites W2088287974 @default.
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• W4313530025 cites W2166032823 @default.
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• W4313530025 cites W2591546762 @default.
• W4313530025 cites W2599958071 @default.
• W4313530025 cites W2604219750 @default.
• W4313530025 cites W2611967647 @default.
• W4313530025 cites W2701067758 @default.
• W4313530025 cites W2767173516 @default.
• W4313530025 cites W2782716004 @default.
• W4313530025 cites W2782948430 @default.
• W4313530025 cites W2792497250 @default.
• W4313530025 cites W2792784654 @default.
• W4313530025 cites W2801894918 @default.
• W4313530025 cites W2808264767 @default.
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• W4313530025 cites W2921107315 @default.
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• W4313530025 cites W3016877518 @default.
• W4313530025 cites W3021373673 @default.
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• W4313530025 doi "https://doi.org/10.1016/j.inoche.2023.110392" @default.
• W4313530025 hasPublicationYear "2023" @default.
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