FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313530054> ?p ?o ?g. }

• W4313530054 endingPage "122580" @default.
• W4313530054 startingPage "122580" @default.
• W4313530054 abstract "Non-melanoma skin cancer is one of the most common malignancies reported with high number of morbidities, demanding an advanced treatment option with superior chemotherapeutic effects. Due to high degree of drug resistance, conventional therapy fails to meet the desired therapeutic efficacy. To break the bottleneck, nanoparticles have been used as next generation vehicles that facilitate the efficient interaction with the cancer cells. Here, we developed combined therapy of 5-fluorouracil (5-FU) and cannabidiol (CBD)-loaded nanostructured lipid carrier gel (FU-CBD-NLCs gel). The NLCs were optimized using central composite design that showed an average particle size of 206 nm and a zeta potential of −34 mV. In addition, in vitro and ex vivo drug permeations studies demonstrated the effective delivery of both drugs in the skin layers via lipid structured nanocarriers. Also, the prepared FU-CBD-NLCs showed promising effect in-vitro cell studies including MTT assays, wound healing and cell cycle as compared to the conventional formulation. Moreover, dermatokinetic studies shows there was superior deposition of drugs at epidermal and the dermal layer when treated with FU-CBD-NLCs. In the end, overall study offered a novel combinatorial chemotherapy that could be an option for the treatment of non-melanoma skin cancer." @default.
• W4313530054 created "2023-01-06" @default.
• W4313530054 creator A5017582048 @default.
• W4313530054 creator A5030449890 @default.
• W4313530054 creator A5032684648 @default.
• W4313530054 creator A5045032651 @default.
• W4313530054 creator A5045330495 @default.
• W4313530054 creator A5056613177 @default.
• W4313530054 creator A5060045961 @default.
• W4313530054 creator A5063942987 @default.
• W4313530054 creator A5082993311 @default.
• W4313530054 creator A5087908803 @default.
• W4313530054 date "2023-02-01" @default.
• W4313530054 modified "2023-10-17" @default.
• W4313530054 title "Formulation and development of novel lipid-based combinatorial advanced nanoformulation for effective treatment of non-melanoma skin cancer" @default.
• W4313530054 cites W1963509607 @default.
• W4313530054 cites W1964891492 @default.
• W4313530054 cites W1977651719 @default.
• W4313530054 cites W1993835039 @default.
• W4313530054 cites W2011920500 @default.
• W4313530054 cites W2472317901 @default.
• W4313530054 cites W2703979707 @default.
• W4313530054 cites W2793274690 @default.
• W4313530054 cites W2800926573 @default.
• W4313530054 cites W3012817514 @default.
• W4313530054 cites W3022269000 @default.
• W4313530054 cites W3022570411 @default.
• W4313530054 cites W3033190169 @default.
• W4313530054 cites W3045553188 @default.
• W4313530054 cites W3082866670 @default.
• W4313530054 cites W3126848972 @default.
• W4313530054 cites W3135672591 @default.
• W4313530054 cites W3152963860 @default.
• W4313530054 cites W3190273266 @default.
• W4313530054 cites W3196002498 @default.
• W4313530054 cites W3203396486 @default.
• W4313530054 cites W4210373826 @default.
• W4313530054 cites W4220786403 @default.
• W4313530054 cites W4220809866 @default.
• W4313530054 cites W4220950718 @default.
• W4313530054 cites W4220957484 @default.
• W4313530054 cites W4224032501 @default.
• W4313530054 cites W4281561624 @default.
• W4313530054 cites W4281640467 @default.
• W4313530054 cites W4285726592 @default.
• W4313530054 cites W4289712318 @default.
• W4313530054 cites W4290791790 @default.
• W4313530054 doi "https://doi.org/10.1016/j.ijpharm.2022.122580" @default.
• W4313530054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608807" @default.
• W4313530054 hasPublicationYear "2023" @default.
• W4313530054 type Work @default.
• W4313530054 citedByCount "16" @default.
• W4313530054 countsByYear W43135300542023 @default.
• W4313530054 crossrefType "journal-article" @default.
• W4313530054 hasAuthorship W4313530054A5017582048 @default.
• W4313530054 hasAuthorship W4313530054A5030449890 @default.
• W4313530054 hasAuthorship W4313530054A5032684648 @default.
• W4313530054 hasAuthorship W4313530054A5045032651 @default.
• W4313530054 hasAuthorship W4313530054A5045330495 @default.
• W4313530054 hasAuthorship W4313530054A5056613177 @default.
• W4313530054 hasAuthorship W4313530054A5060045961 @default.
• W4313530054 hasAuthorship W4313530054A5063942987 @default.
• W4313530054 hasAuthorship W4313530054A5082993311 @default.
• W4313530054 hasAuthorship W4313530054A5087908803 @default.
• W4313530054 hasConcept C121608353 @default.
• W4313530054 hasConcept C126322002 @default.
• W4313530054 hasConcept C141071460 @default.
• W4313530054 hasConcept C150903083 @default.
• W4313530054 hasConcept C155672457 @default.
• W4313530054 hasConcept C171250308 @default.
• W4313530054 hasConcept C18150654 @default.
• W4313530054 hasConcept C185592680 @default.
• W4313530054 hasConcept C192562407 @default.
• W4313530054 hasConcept C202751555 @default.
• W4313530054 hasConcept C207001950 @default.
• W4313530054 hasConcept C26291073 @default.
• W4313530054 hasConcept C2776694085 @default.
• W4313530054 hasConcept C2777658100 @default.
• W4313530054 hasConcept C2777789703 @default.
• W4313530054 hasConcept C2780035454 @default.
• W4313530054 hasConcept C502942594 @default.
• W4313530054 hasConcept C55493867 @default.
• W4313530054 hasConcept C71924100 @default.
• W4313530054 hasConcept C86181022 @default.
• W4313530054 hasConcept C86803240 @default.
• W4313530054 hasConcept C98274493 @default.
• W4313530054 hasConceptScore W4313530054C121608353 @default.
• W4313530054 hasConceptScore W4313530054C126322002 @default.
• W4313530054 hasConceptScore W4313530054C141071460 @default.
• W4313530054 hasConceptScore W4313530054C150903083 @default.
• W4313530054 hasConceptScore W4313530054C155672457 @default.
• W4313530054 hasConceptScore W4313530054C171250308 @default.
• W4313530054 hasConceptScore W4313530054C18150654 @default.
• W4313530054 hasConceptScore W4313530054C185592680 @default.
• W4313530054 hasConceptScore W4313530054C192562407 @default.
• W4313530054 hasConceptScore W4313530054C202751555 @default.
• W4313530054 hasConceptScore W4313530054C207001950 @default.
• W4313530054 hasConceptScore W4313530054C26291073 @default.

• next