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- W4313530460 abstract "Meteorin-like (Metrnl) is a novel immune regulatory factor or adipokine which is mainly produced by activated macrophages. In teleost fish, two homologs are present. In this study, monoclonal antibodies were prepared against recombinant grass carp (Ctenopharyngodon idella, Ci) Metrnl-a in mice and characterized by Western blotting, flow cytometry and immunofluorescent microscopy. In grass carp infected with Aeromonus hydrophila (A. hydrophila), the cells expressing CiMetrnl-a markedly increased in the gills, head kidney and intestine. In the inflamed intestine caused by A. hydrophila infection, the CiMetrnl-a producing cells were detected mainly in the mucosal layer of anterior, middle and posterior segments. Consistently, qRT-PCR analysis showed that the mRNA expression of CiMetrnl-a was markedly induced. Our results suggest that CiMetrnl-a is involved in regulating intestine inflammation caused by bacterial infection." @default.
- W4313530460 created "2023-01-06" @default.
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- W4313530460 date "2023-04-01" @default.
- W4313530460 modified "2023-10-01" @default.
- W4313530460 title "The Meteorin-like cytokine is upregulated in grass carp after infection with Aeromonas hydrophila" @default.
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- W4313530460 doi "https://doi.org/10.1016/j.dci.2023.104632" @default.
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