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- W4313531595 endingPage "100912" @default.
- W4313531595 startingPage "100912" @default.
- W4313531595 abstract "Prostate cancer (PCa) is one of the most lethal causes of cancer-related death in male. It is characterized by chromosomal instability and disturbed signaling transduction. E3 ubiquitin ligases are well-recognized as mediators leading to genomic alterations and malignant phenotypes. There is a lack of systematic study on novel oncodrivers with genomic and clinical significance in PCa. In this study we used clustered regularly interspaced short palindromic repeats (CRISPR) system to screen 656 E3 ubiquitin ligases as oncodrivers or tumor repressors in PCa cells. We identified 51 significantly changed genes, and conducted genomic and clinical analysis on these genes. It was found that the Ring Finger Protein 19 A (RNF19A) was a novel oncodriver in PCa. RNF19A was frequently amplified and highly expressed in PCa and other cancer types. Clinically, higher RNF19A expression correlated with advanced Gleason Score and predicted castration resistance. Mechanistically, transcriptomics, quantitative and ubiquitination proteomic analysis showed that RNF19A ubiquitylated Thyroid Hormone Receptor Interactor 13 (TRIP13) and was transcriptionally activated by androgen receptor (AR) and Hypoxia Inducible Factor 1 Subunit Alpha (HIF1A). This study uncovers the genomic and clinical significance of a oncodriver RNF19A in PCa. The results of this study indicate that targeting AR/HIF1A-RNF19A-TRIP13 signaling axis could be an alternative option for PCa diagnosis and therapy." @default.
- W4313531595 created "2023-01-06" @default.
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- W4313531595 date "2023-03-01" @default.
- W4313531595 modified "2023-10-09" @default.
- W4313531595 title "CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer" @default.
- W4313531595 cites W1986927768 @default.
- W4313531595 cites W2005760671 @default.
- W4313531595 cites W2011714693 @default.
- W4313531595 cites W2012920679 @default.
- W4313531595 cites W2032212474 @default.
- W4313531595 cites W2036325451 @default.
- W4313531595 cites W2092163286 @default.
- W4313531595 cites W2141077390 @default.
- W4313531595 cites W2152740195 @default.
- W4313531595 cites W2172602305 @default.
- W4313531595 cites W2470758117 @default.
- W4313531595 cites W2517249443 @default.
- W4313531595 cites W2554405527 @default.
- W4313531595 cites W2565255170 @default.
- W4313531595 cites W2599453624 @default.
- W4313531595 cites W2625817416 @default.
- W4313531595 cites W2754374178 @default.
- W4313531595 cites W2773048783 @default.
- W4313531595 cites W2788783025 @default.
- W4313531595 cites W2796153225 @default.
- W4313531595 cites W2802842470 @default.
- W4313531595 cites W2807317262 @default.
- W4313531595 cites W2809938859 @default.
- W4313531595 cites W2865431834 @default.
- W4313531595 cites W2892691799 @default.
- W4313531595 cites W2893277845 @default.
- W4313531595 cites W2898747775 @default.
- W4313531595 cites W2900310474 @default.
- W4313531595 cites W2912138638 @default.
- W4313531595 cites W2912739143 @default.
- W4313531595 cites W2946701636 @default.
- W4313531595 cites W2955325901 @default.
- W4313531595 cites W2971922700 @default.
- W4313531595 cites W2972354393 @default.
- W4313531595 cites W2991669855 @default.
- W4313531595 cites W3000138169 @default.
- W4313531595 cites W3000673710 @default.
- W4313531595 cites W3005777982 @default.
- W4313531595 cites W3013598421 @default.
- W4313531595 cites W3014505500 @default.
- W4313531595 cites W3015604723 @default.
- W4313531595 cites W3017508752 @default.
- W4313531595 cites W3027025155 @default.
- W4313531595 cites W3038325504 @default.
- W4313531595 cites W3041912701 @default.
- W4313531595 cites W3082714866 @default.
- W4313531595 cites W3091811222 @default.
- W4313531595 cites W3097843874 @default.
- W4313531595 cites W3111735680 @default.
- W4313531595 cites W3118235024 @default.
- W4313531595 cites W3127334834 @default.
- W4313531595 cites W3162847526 @default.
- W4313531595 cites W3167977328 @default.
- W4313531595 cites W3173564566 @default.
- W4313531595 cites W3174994934 @default.
- W4313531595 cites W3183624135 @default.
- W4313531595 cites W3183938815 @default.
- W4313531595 cites W3195271031 @default.
- W4313531595 cites W3198416391 @default.
- W4313531595 cites W3210830659 @default.
- W4313531595 cites W3213630353 @default.
- W4313531595 cites W3213764017 @default.
- W4313531595 cites W4200270405 @default.
- W4313531595 cites W4200393134 @default.
- W4313531595 cites W4205360868 @default.
- W4313531595 cites W4207002757 @default.
- W4313531595 cites W4210424128 @default.
- W4313531595 cites W4220856282 @default.
- W4313531595 cites W4223431168 @default.
- W4313531595 cites W4225687325 @default.
- W4313531595 cites W4229442827 @default.
- W4313531595 cites W4283451354 @default.
- W4313531595 cites W4284966986 @default.
- W4313531595 cites W4286587120 @default.
- W4313531595 cites W4290034386 @default.
- W4313531595 cites W4293802433 @default.
- W4313531595 cites W4294863500 @default.
- W4313531595 cites W4296162807 @default.
- W4313531595 doi "https://doi.org/10.1016/j.drup.2022.100912" @default.
- W4313531595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36623445" @default.
- W4313531595 hasPublicationYear "2023" @default.
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