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- W4313531718 abstract "Metabolic communication in the tumor microenvironment underscores tumor-immune interactions and affects anti-tumor immunity, yet cell-extrinsic signals driving tumor metabolic remodeling are incompletely understood. In this issue, Tsai et al. show that during initial tumorigenesis, T cell-derived IFNγ triggers STAT3 activation and c-Myc-dependent alterations of tumor cell metabolism, which potentiates immune evasion. Metabolic communication in the tumor microenvironment underscores tumor-immune interactions and affects anti-tumor immunity, yet cell-extrinsic signals driving tumor metabolic remodeling are incompletely understood. In this issue, Tsai et al. show that during initial tumorigenesis, T cell-derived IFNγ triggers STAT3 activation and c-Myc-dependent alterations of tumor cell metabolism, which potentiates immune evasion. Immunoediting instructs tumor metabolic reprogramming to support immune evasionTsai et al.Cell MetabolismJanuary 03, 2023In BriefMetabolic reprogramming, generally believed to be controlled by oncogenic mutations and hypoxia, supports tumor proliferation, anti-apoptosis, and metastasis. Here, we uncover an unexplored action of IFNγ by which T cell-mediated immunosurveillance impacts epigenetic architecture and gene expression in tumor cells that boosts cMyc-dependent metabolic reprogramming and tumor immune evasion. Full-Text PDF" @default.
- W4313531718 created "2023-01-06" @default.
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- W4313531718 date "2023-01-01" @default.
- W4313531718 modified "2023-09-25" @default.
- W4313531718 title "Early immune pressure makes tumors metabolically stronger" @default.
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- W4313531718 doi "https://doi.org/10.1016/j.cmet.2022.12.009" @default.
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