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- W4313531903 endingPage "165.e4" @default.
- W4313531903 startingPage "150" @default.
- W4313531903 abstract "Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health benefits that arise from multiple organ systems, yet the molecular basis of TRF-mediated benefits is not well understood. Here, we subjected mice to isocaloric ad libitum feeding (ALF) or TRF of a western diet and examined gene expression changes in samples taken from 22 organs and brain regions collected every 2 h over a 24-h period. We discovered that TRF profoundly impacts gene expression. Nearly 80% of all genes show differential expression or rhythmicity under TRF in at least one tissue. Functional annotation of these changes revealed tissue- and pathway-specific impacts of TRF. These findings and resources provide a critical foundation for future mechanistic studies and will help to guide human time-restricted eating (TRE) interventions to treat various disease conditions with or without pharmacotherapies." @default.
- W4313531903 created "2023-01-06" @default.
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- W4313531903 date "2023-01-01" @default.
- W4313531903 modified "2023-10-16" @default.
- W4313531903 title "Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals" @default.
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- W4313531903 doi "https://doi.org/10.1016/j.cmet.2022.12.006" @default.
- W4313531903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36599299" @default.
- W4313531903 hasPublicationYear "2023" @default.
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