Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313531965> ?p ?o ?g. }
- W4313531965 endingPage "120492" @default.
- W4313531965 startingPage "120492" @default.
- W4313531965 abstract "Regeneration of injured articular cartilage is limited by low early-stage recruitment of stem cells and insufficient chondrogenic differentiation. Hydrogels are widely used to repair cartilage because they have excellent mechanical and biological properties. In this study, a dual drug-loaded thermosensitive hydroxypropyl chitin hydrogel (HPCH) system was prepared to release stromal-derived factor-1α-like polypeptides (SDFP) and kartogenin (KGN) for stem-cell recruitment and chondrogenic differentiation. The hydrogel had a network structure that promoted cell growth and nutrient exchange. Moreover, it was temperature sensitive and suitable for filling irregular defects. The system showed good biocompatibility in vitro and promoted stem-cell recruitment and chondrogenic differentiation. Furthermore, it reduced chondrocyte catabolism under inflammatory conditions. Animal experiments demonstrated that the dual-drug hydrogel systems can promote the regeneration of articular cartilage in rats. This study confirmed that an HPCH system loaded with KGN and SDFP could effectively repair articular cartilage defects and represents a viable treatment strategy." @default.
- W4313531965 created "2023-01-06" @default.
- W4313531965 creator A5000624318 @default.
- W4313531965 creator A5005421293 @default.
- W4313531965 creator A5037412579 @default.
- W4313531965 creator A5048875330 @default.
- W4313531965 creator A5049692788 @default.
- W4313531965 creator A5052481288 @default.
- W4313531965 creator A5061541550 @default.
- W4313531965 creator A5062990452 @default.
- W4313531965 creator A5067298419 @default.
- W4313531965 creator A5072817787 @default.
- W4313531965 creator A5082707881 @default.
- W4313531965 creator A5088705161 @default.
- W4313531965 date "2023-03-01" @default.
- W4313531965 modified "2023-09-30" @default.
- W4313531965 title "Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin" @default.
- W4313531965 cites W1841535257 @default.
- W4313531965 cites W1963504754 @default.
- W4313531965 cites W2031964593 @default.
- W4313531965 cites W2033223267 @default.
- W4313531965 cites W2142801671 @default.
- W4313531965 cites W2575229100 @default.
- W4313531965 cites W2620695719 @default.
- W4313531965 cites W2740662952 @default.
- W4313531965 cites W2794148347 @default.
- W4313531965 cites W2804501129 @default.
- W4313531965 cites W2810859348 @default.
- W4313531965 cites W2914603303 @default.
- W4313531965 cites W2942059957 @default.
- W4313531965 cites W2954251291 @default.
- W4313531965 cites W2984823884 @default.
- W4313531965 cites W2991834850 @default.
- W4313531965 cites W2999598718 @default.
- W4313531965 cites W3006427460 @default.
- W4313531965 cites W3010630785 @default.
- W4313531965 cites W3014396443 @default.
- W4313531965 cites W3037292907 @default.
- W4313531965 cites W3040504914 @default.
- W4313531965 cites W3092452908 @default.
- W4313531965 cites W3110255117 @default.
- W4313531965 cites W3117515627 @default.
- W4313531965 cites W3118216554 @default.
- W4313531965 cites W3162620440 @default.
- W4313531965 cites W3166909071 @default.
- W4313531965 cites W3199758915 @default.
- W4313531965 cites W3200418190 @default.
- W4313531965 cites W3203077012 @default.
- W4313531965 cites W3213154417 @default.
- W4313531965 cites W3215893346 @default.
- W4313531965 cites W4220747502 @default.
- W4313531965 cites W4220933801 @default.
- W4313531965 cites W4283020490 @default.
- W4313531965 cites W4283580988 @default.
- W4313531965 doi "https://doi.org/10.1016/j.carbpol.2022.120492" @default.
- W4313531965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36641179" @default.
- W4313531965 hasPublicationYear "2023" @default.
- W4313531965 type Work @default.
- W4313531965 citedByCount "4" @default.
- W4313531965 countsByYear W43135319652023 @default.
- W4313531965 crossrefType "journal-article" @default.
- W4313531965 hasAuthorship W4313531965A5000624318 @default.
- W4313531965 hasAuthorship W4313531965A5005421293 @default.
- W4313531965 hasAuthorship W4313531965A5037412579 @default.
- W4313531965 hasAuthorship W4313531965A5048875330 @default.
- W4313531965 hasAuthorship W4313531965A5049692788 @default.
- W4313531965 hasAuthorship W4313531965A5052481288 @default.
- W4313531965 hasAuthorship W4313531965A5061541550 @default.
- W4313531965 hasAuthorship W4313531965A5062990452 @default.
- W4313531965 hasAuthorship W4313531965A5067298419 @default.
- W4313531965 hasAuthorship W4313531965A5072817787 @default.
- W4313531965 hasAuthorship W4313531965A5082707881 @default.
- W4313531965 hasAuthorship W4313531965A5088705161 @default.
- W4313531965 hasConcept C105702510 @default.
- W4313531965 hasConcept C108586683 @default.
- W4313531965 hasConcept C136229726 @default.
- W4313531965 hasConcept C142724271 @default.
- W4313531965 hasConcept C16930146 @default.
- W4313531965 hasConcept C171056886 @default.
- W4313531965 hasConcept C178790620 @default.
- W4313531965 hasConcept C185592680 @default.
- W4313531965 hasConcept C188027245 @default.
- W4313531965 hasConcept C198826908 @default.
- W4313531965 hasConcept C204787440 @default.
- W4313531965 hasConcept C2776164576 @default.
- W4313531965 hasConcept C2777230088 @default.
- W4313531965 hasConcept C2777564180 @default.
- W4313531965 hasConcept C2779820397 @default.
- W4313531965 hasConcept C2780550940 @default.
- W4313531965 hasConcept C2781403057 @default.
- W4313531965 hasConcept C28328180 @default.
- W4313531965 hasConcept C3020332539 @default.
- W4313531965 hasConcept C35496256 @default.
- W4313531965 hasConcept C502942594 @default.
- W4313531965 hasConcept C71924100 @default.
- W4313531965 hasConcept C86803240 @default.
- W4313531965 hasConcept C95444343 @default.
- W4313531965 hasConceptScore W4313531965C105702510 @default.