Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313531982> ?p ?o ?g. }
- W4313531982 endingPage "260" @default.
- W4313531982 startingPage "246" @default.
- W4313531982 abstract "Deep brain stimulation (DBS) is a neuromodulation method that modulates neuronal activity. A trend in the treatment of Alzheimer’s disease (AD) is targeting key points of neural circuits with DBS. Here, we explored the effects of DBS targeted to the entorhinal cortex (EC) on neurons in the hippocampal CA1 in a mouse model of preclinical AD. Specifically, we recorded field potential signals from CA1 in preclinical AD mice after DBS of the EC (1 h/day for 21 days of 100 μA, 90 μs, 10 Hz, biphasic square wave pulse) with in-vivo electrophysiology and evaluated corresponding changes in behavior with the open field task and Morris water maze (MWM) task. We also assessed changes in pathological markers and neurogenesis in the hippocampus with immunohistological staining. DBS of the EC increased theta and gamma power and modulated theta in the high gamma band (50–100 Hz) in preclinical AD mice. After DBS of the EC, these mice performed better in the MWM task and exhibited reduced deposition of beta-amyloid and neuronal changes including significant increases in proliferating neurons and immature neurons. This is the first study to target the EC with DBS and analyze resulting neural oscillations in the hippocampal CA1 in a model of preclinical AD. The findings support the use of DBS as a potential treatment for AD." @default.
- W4313531982 created "2023-01-06" @default.
- W4313531982 creator A5019927482 @default.
- W4313531982 creator A5029851581 @default.
- W4313531982 creator A5032099889 @default.
- W4313531982 creator A5035643040 @default.
- W4313531982 creator A5042687602 @default.
- W4313531982 creator A5049709428 @default.
- W4313531982 creator A5051126495 @default.
- W4313531982 creator A5054638833 @default.
- W4313531982 creator A5063671472 @default.
- W4313531982 creator A5089151690 @default.
- W4313531982 date "2023-01-01" @default.
- W4313531982 modified "2023-09-26" @default.
- W4313531982 title "Deep brain stimulation of the entorhinal cortex modulates CA1 theta-gamma oscillations in mouse models of preclinical Alzheimer's disease" @default.
- W4313531982 cites W1829183563 @default.
- W4313531982 cites W1968701523 @default.
- W4313531982 cites W1974791004 @default.
- W4313531982 cites W1982313782 @default.
- W4313531982 cites W1982695759 @default.
- W4313531982 cites W1996032190 @default.
- W4313531982 cites W2000446844 @default.
- W4313531982 cites W2016520377 @default.
- W4313531982 cites W2022539825 @default.
- W4313531982 cites W2026393786 @default.
- W4313531982 cites W2030428255 @default.
- W4313531982 cites W2032193569 @default.
- W4313531982 cites W2037413727 @default.
- W4313531982 cites W2051007514 @default.
- W4313531982 cites W2052742260 @default.
- W4313531982 cites W2056336718 @default.
- W4313531982 cites W2057608998 @default.
- W4313531982 cites W2062505106 @default.
- W4313531982 cites W2091447671 @default.
- W4313531982 cites W2096577216 @default.
- W4313531982 cites W2099512174 @default.
- W4313531982 cites W2129497119 @default.
- W4313531982 cites W2132668024 @default.
- W4313531982 cites W2145796722 @default.
- W4313531982 cites W2151442629 @default.
- W4313531982 cites W2158768490 @default.
- W4313531982 cites W2168720389 @default.
- W4313531982 cites W2171250577 @default.
- W4313531982 cites W2410841132 @default.
- W4313531982 cites W2487318252 @default.
- W4313531982 cites W2512047842 @default.
- W4313531982 cites W2556389549 @default.
- W4313531982 cites W2564442487 @default.
- W4313531982 cites W2568913537 @default.
- W4313531982 cites W2586088462 @default.
- W4313531982 cites W2594653909 @default.
- W4313531982 cites W2602373342 @default.
- W4313531982 cites W2617664085 @default.
- W4313531982 cites W2766303388 @default.
- W4313531982 cites W2768690074 @default.
- W4313531982 cites W2790870786 @default.
- W4313531982 cites W2800027635 @default.
- W4313531982 cites W2801939620 @default.
- W4313531982 cites W2803024172 @default.
- W4313531982 cites W2808280305 @default.
- W4313531982 cites W2904244708 @default.
- W4313531982 cites W2909871453 @default.
- W4313531982 cites W2912123407 @default.
- W4313531982 cites W2948283811 @default.
- W4313531982 cites W2953271438 @default.
- W4313531982 cites W2967241608 @default.
- W4313531982 cites W3007593444 @default.
- W4313531982 cites W3011079372 @default.
- W4313531982 cites W3024141471 @default.
- W4313531982 cites W3025526179 @default.
- W4313531982 cites W3040097459 @default.
- W4313531982 cites W3134901223 @default.
- W4313531982 cites W3159530258 @default.
- W4313531982 cites W3177379483 @default.
- W4313531982 cites W4200115256 @default.
- W4313531982 cites W815050927 @default.
- W4313531982 doi "https://doi.org/10.1016/j.bbe.2022.12.010" @default.
- W4313531982 hasPublicationYear "2023" @default.
- W4313531982 type Work @default.
- W4313531982 citedByCount "0" @default.
- W4313531982 crossrefType "journal-article" @default.
- W4313531982 hasAuthorship W4313531982A5019927482 @default.
- W4313531982 hasAuthorship W4313531982A5029851581 @default.
- W4313531982 hasAuthorship W4313531982A5032099889 @default.
- W4313531982 hasAuthorship W4313531982A5035643040 @default.
- W4313531982 hasAuthorship W4313531982A5042687602 @default.
- W4313531982 hasAuthorship W4313531982A5049709428 @default.
- W4313531982 hasAuthorship W4313531982A5051126495 @default.
- W4313531982 hasAuthorship W4313531982A5054638833 @default.
- W4313531982 hasAuthorship W4313531982A5063671472 @default.
- W4313531982 hasAuthorship W4313531982A5089151690 @default.
- W4313531982 hasBestOaLocation W43135319821 @default.
- W4313531982 hasConcept C117838684 @default.
- W4313531982 hasConcept C118403218 @default.
- W4313531982 hasConcept C142724271 @default.
- W4313531982 hasConcept C148762608 @default.
- W4313531982 hasConcept C15744967 @default.
- W4313531982 hasConcept C169760540 @default.