FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313532514> ?p ?o ?g. }

• W4313532514 endingPage "247" @default.
• W4313532514 startingPage "231" @default.
• W4313532514 abstract "Human Leukocyte Antigens (HLA) are cell surface molecules, central in coordinating innate and adaptive immune responses, that are targets of strong diversifying natural selection by pathogens. Of these pathogens, human herpesviruses have a uniquely ancient relationship with our species, where coevolution likely has reciprocating impact on HLA and viral genomic diversity. Consistent with this notion, genetic variation at multiple HLA loci is strongly associated with modulating immunity to herpesvirus infection. Here, we synthesize published genetic associations of HLA with herpesvirus infection and disease, both from case/control and genome-wide association studies. We analyze genetic associations across the eight human herpesviruses and identify HLA alleles that are associated with diverse herpesvirus-related phenotypes. We find that whereas most HLA genetic associations are virus- or disease-specific, HLA-A*01 and HLA-A*02 allotypes may be more generally associated with immune susceptibility and control, respectively, across multiple herpesviruses. Connecting genetic association data with functional corroboration, we discuss mechanisms by which diverse HLA and cognate receptor allotypes direct variable immune responses during herpesvirus infection and pathogenesis. Together, this review examines the complexity of HLA-herpesvirus interactions driven by differential T cell and Natural Killer cell immune responses." @default.
• W4313532514 created "2023-01-06" @default.
• W4313532514 creator A5025812799 @default.
• W4313532514 creator A5081211984 @default.
• W4313532514 date "2023-01-03" @default.
• W4313532514 modified "2023-10-06" @default.
• W4313532514 title "The impact of HLA polymorphism on herpesvirus infection and disease" @default.
• W4313532514 cites W1523486567 @default.
• W4313532514 cites W1533264279 @default.
• W4313532514 cites W1539825275 @default.
• W4313532514 cites W1540836103 @default.
• W4313532514 cites W1557226440 @default.
• W4313532514 cites W1558762228 @default.
• W4313532514 cites W1564118140 @default.
• W4313532514 cites W1578639821 @default.
• W4313532514 cites W1601440281 @default.
• W4313532514 cites W1762234137 @default.
• W4313532514 cites W1836390862 @default.
• W4313532514 cites W1846859917 @default.
• W4313532514 cites W1884857780 @default.
• W4313532514 cites W1903558905 @default.
• W4313532514 cites W1928377279 @default.
• W4313532514 cites W1929921649 @default.
• W4313532514 cites W1938553683 @default.
• W4313532514 cites W1940192714 @default.
• W4313532514 cites W1952476462 @default.
• W4313532514 cites W195296964 @default.
• W4313532514 cites W1957027480 @default.
• W4313532514 cites W1964882815 @default.
• W4313532514 cites W1969822773 @default.
• W4313532514 cites W1971249889 @default.
• W4313532514 cites W1971287207 @default.
• W4313532514 cites W1972014461 @default.
• W4313532514 cites W1973571641 @default.
• W4313532514 cites W1974670739 @default.
• W4313532514 cites W1975701983 @default.
• W4313532514 cites W1976669171 @default.
• W4313532514 cites W1980175190 @default.
• W4313532514 cites W1981006469 @default.
• W4313532514 cites W1982946090 @default.
• W4313532514 cites W1984899257 @default.
• W4313532514 cites W1985550099 @default.
• W4313532514 cites W1987853079 @default.
• W4313532514 cites W1989065947 @default.
• W4313532514 cites W1989166597 @default.
• W4313532514 cites W1989729492 @default.
• W4313532514 cites W1989733951 @default.
• W4313532514 cites W1991622884 @default.
• W4313532514 cites W1991992194 @default.
• W4313532514 cites W1992849411 @default.
• W4313532514 cites W1993571469 @default.
• W4313532514 cites W1994716838 @default.
• W4313532514 cites W1995334258 @default.
• W4313532514 cites W1998233030 @default.
• W4313532514 cites W2000045443 @default.
• W4313532514 cites W2001855400 @default.
• W4313532514 cites W2005863787 @default.
• W4313532514 cites W2012535996 @default.
• W4313532514 cites W2014211213 @default.
• W4313532514 cites W2014254835 @default.
• W4313532514 cites W2023450134 @default.
• W4313532514 cites W2027691331 @default.
• W4313532514 cites W2029491958 @default.
• W4313532514 cites W2030274612 @default.
• W4313532514 cites W2031057215 @default.
• W4313532514 cites W2035349831 @default.
• W4313532514 cites W2041413771 @default.
• W4313532514 cites W2042361781 @default.
• W4313532514 cites W2043130534 @default.
• W4313532514 cites W2043277672 @default.
• W4313532514 cites W2043570079 @default.
• W4313532514 cites W2045407060 @default.
• W4313532514 cites W2047985862 @default.
• W4313532514 cites W2050311290 @default.
• W4313532514 cites W2050672588 @default.
• W4313532514 cites W2050673484 @default.
• W4313532514 cites W2051103323 @default.
• W4313532514 cites W2052667644 @default.
• W4313532514 cites W2055622515 @default.
• W4313532514 cites W2056384440 @default.
• W4313532514 cites W2056768253 @default.
• W4313532514 cites W2060122838 @default.
• W4313532514 cites W2061630978 @default.
• W4313532514 cites W2061902395 @default.
• W4313532514 cites W2062840842 @default.
• W4313532514 cites W2064140853 @default.
• W4313532514 cites W2064926431 @default.
• W4313532514 cites W2066082105 @default.
• W4313532514 cites W2066803165 @default.
• W4313532514 cites W2073572679 @default.
• W4313532514 cites W2073621589 @default.
• W4313532514 cites W2076628448 @default.
• W4313532514 cites W2078834161 @default.
• W4313532514 cites W2083514525 @default.
• W4313532514 cites W2083592738 @default.
• W4313532514 cites W2085104810 @default.
• W4313532514 cites W2086419697 @default.
• W4313532514 cites W2086795402 @default.

• next