FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313532853> ?p ?o ?g. }

• W4313532853 abstract "Abstract Candida albicans is an opportunistic pathogen that can thrive under adverse conditions including suboptimal pH, nutrient scarcity, and low levels of oxygen. Its pathogenicity is associated with the production of virulence factors such as extracellular hydrolytic enzymes and toxins. This study was aimed at determining the effect of external pH, substrate nature, and strain origin on protease, lipase, and hemolysin production. To achieve this objective, agar plate assays were performed at pH 5.0, 6.5, and 7.5 with substrates suitable for the detection of each family of enzymes. Moreover, the study was conducted with 20 clinical C. albicans isolates from blood, oral cavity, skin, urine, and vagina. The hydrolytic zones formed around the colonies were further measured to calculate the Ez (enzymatic zone) indexes. We found that detection of proteases in skim milk agar plates was possible for most isolates only at pH 5 (80%) and pH 6.5 (75%), whereas BSA plates could confer protease detection exclusively at pH 5 (80%). Similarly, the percentage of isolates possessing lipolytic activities was higher at pH 5 (90%) than at pH 6.5 (70%) and pH 7.5 (35%). In contrast, hemolytic activities were detected in all isolates at pH 6.5 and 7.5 but not at pH 5. Further analysis revealed that some differences in the detected activities could potentially be attributed to the anatomical origin of these isolates. Collectively, these findings suggest that the pH of the site of infection might be critical for mimicking the microenvironment employed to experimentally discover the key virulence factors." @default.
• W4313532853 created "2023-01-06" @default.
• W4313532853 creator A5031727343 @default.
• W4313532853 creator A5032779260 @default.
• W4313532853 creator A5033089266 @default.
• W4313532853 creator A5046323184 @default.
• W4313532853 creator A5078514741 @default.
• W4313532853 creator A5089101601 @default.
• W4313532853 date "2023-01-03" @default.
• W4313532853 modified "2023-10-01" @default.
• W4313532853 title "Assessing pH‐dependent activities of virulence factors secreted by <i>Candida albicans</i>" @default.
• W4313532853 cites W1827441128 @default.
• W4313532853 cites W1893369945 @default.
• W4313532853 cites W1940720973 @default.
• W4313532853 cites W1964900779 @default.
• W4313532853 cites W1982612096 @default.
• W4313532853 cites W2006790257 @default.
• W4313532853 cites W2015958383 @default.
• W4313532853 cites W2020290349 @default.
• W4313532853 cites W2022531352 @default.
• W4313532853 cites W2039791523 @default.
• W4313532853 cites W2042655557 @default.
• W4313532853 cites W2062758606 @default.
• W4313532853 cites W2088069906 @default.
• W4313532853 cites W2089205150 @default.
• W4313532853 cites W2093869242 @default.
• W4313532853 cites W2105515468 @default.
• W4313532853 cites W2110010885 @default.
• W4313532853 cites W2115834673 @default.
• W4313532853 cites W2119468962 @default.
• W4313532853 cites W2129707391 @default.
• W4313532853 cites W2138873249 @default.
• W4313532853 cites W2140865595 @default.
• W4313532853 cites W2144035662 @default.
• W4313532853 cites W2224009464 @default.
• W4313532853 cites W2317674131 @default.
• W4313532853 cites W2335633601 @default.
• W4313532853 cites W2344364497 @default.
• W4313532853 cites W2614121138 @default.
• W4313532853 cites W2769719637 @default.
• W4313532853 cites W2775842006 @default.
• W4313532853 cites W2815663922 @default.
• W4313532853 cites W2885246726 @default.
• W4313532853 cites W2900853140 @default.
• W4313532853 cites W2910820369 @default.
• W4313532853 cites W2916829388 @default.
• W4313532853 cites W2921070821 @default.
• W4313532853 cites W2989875472 @default.
• W4313532853 cites W3033679143 @default.
• W4313532853 cites W3043387638 @default.
• W4313532853 cites W3048954611 @default.
• W4313532853 cites W3086543705 @default.
• W4313532853 cites W3165425323 @default.
• W4313532853 cites W3169708735 @default.
• W4313532853 cites W9853286 @default.
• W4313532853 doi "https://doi.org/10.1002/mbo3.1342" @default.
• W4313532853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36825882" @default.
• W4313532853 hasPublicationYear "2023" @default.
• W4313532853 type Work @default.
• W4313532853 citedByCount "2" @default.
• W4313532853 countsByYear W43135328532023 @default.
• W4313532853 crossrefType "journal-article" @default.
• W4313532853 hasAuthorship W4313532853A5031727343 @default.
• W4313532853 hasAuthorship W4313532853A5032779260 @default.
• W4313532853 hasAuthorship W4313532853A5033089266 @default.
• W4313532853 hasAuthorship W4313532853A5046323184 @default.
• W4313532853 hasAuthorship W4313532853A5078514741 @default.
• W4313532853 hasAuthorship W4313532853A5089101601 @default.
• W4313532853 hasBestOaLocation W43135328531 @default.
• W4313532853 hasConcept C104317684 @default.
• W4313532853 hasConcept C136139683 @default.
• W4313532853 hasConcept C145081991 @default.
• W4313532853 hasConcept C181199279 @default.
• W4313532853 hasConcept C182220744 @default.
• W4313532853 hasConcept C185592680 @default.
• W4313532853 hasConcept C2776714187 @default.
• W4313532853 hasConcept C2779697368 @default.
• W4313532853 hasConcept C2780917455 @default.
• W4313532853 hasConcept C28406088 @default.
• W4313532853 hasConcept C523546767 @default.
• W4313532853 hasConcept C54355233 @default.
• W4313532853 hasConcept C55493867 @default.
• W4313532853 hasConcept C60987743 @default.
• W4313532853 hasConcept C62643968 @default.
• W4313532853 hasConcept C86803240 @default.
• W4313532853 hasConcept C89423630 @default.
• W4313532853 hasConceptScore W4313532853C104317684 @default.
• W4313532853 hasConceptScore W4313532853C136139683 @default.
• W4313532853 hasConceptScore W4313532853C145081991 @default.
• W4313532853 hasConceptScore W4313532853C181199279 @default.
• W4313532853 hasConceptScore W4313532853C182220744 @default.
• W4313532853 hasConceptScore W4313532853C185592680 @default.
• W4313532853 hasConceptScore W4313532853C2776714187 @default.
• W4313532853 hasConceptScore W4313532853C2779697368 @default.
• W4313532853 hasConceptScore W4313532853C2780917455 @default.
• W4313532853 hasConceptScore W4313532853C28406088 @default.
• W4313532853 hasConceptScore W4313532853C523546767 @default.
• W4313532853 hasConceptScore W4313532853C54355233 @default.
• W4313532853 hasConceptScore W4313532853C55493867 @default.
• W4313532853 hasConceptScore W4313532853C60987743 @default.

• next