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- W4313532884 abstract "Abstract Objective This study aims to emphasize the initiating role of facet joint (FJ) degeneration in the process of cervical spine degeneration induced by tangential load, and we further validate it in a novel cervical spine degeneration animal model. Methods The characteristics of cervical degeneration in patients of different ages were summarized through case collection. In the rat models, Hematoxylin–Eosin, Safranin O staining, and micro‐computed tomography were used to show the histopathological changes and bone fiber structure of FJ and the height of intervertebral disc (IVD) space. The ingrowth of nociceptive sensory nerve fibers was observed by immunofluorescence staining. Results FJ degeneration without IVDs degeneration was more common in people with cervical spondylosis in young patients. The obvious degeneration phenotypes of the FJs preceded the IVDs at the same cervical segment in our animal model. The SP + and CGRP + sensory nerve fibers were observed in the articular subchondral bone of degenerated FJs and porous endplates of degenerated IVDs. Conclusion The FJ degeneration may act as the major contributor to cervical spine degeneration in young people. The dysfunction of functional unit of spine, not a certain part of IVD tissue, results in the occurrence of cervical degeneration and neck pain." @default.
- W4313532884 created "2023-01-06" @default.
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- W4313532884 date "2023-01-02" @default.
- W4313532884 modified "2023-10-14" @default.
- W4313532884 title "Facet joint degeneration—An initial procedure of the cervical spine degeneration" @default.
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- W4313532884 doi "https://doi.org/10.1002/jsp2.1241" @default.
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