FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313532980> ?p ?o ?g. }

• W4313532980 abstract "<h3>Background</h3> Neutrophil Extracellular Traps (NETs) have been implicated in Lupus Nephritis (LN) pathogenesis. SLE neutrophils release High Mobility Group Box-1 (HMGB1) protein, in turn, HMGB1 in NETs correlates with histologic findings of Active LN (ALN). The aim was to determine if the amount of NET complexes (Elastase-DNA and HMGB1-DNA) in serum at the time of a LN flare predicts renal outcomes in the following 24 months. <h3>Methods</h3> The study had a 2-staged approach. In an exploratory cohort composed of active SLE (clinical SLEDAI ≥ 1), inactive SLE and healthy controls (HC), we assessed the association between our in-house ELISA assays for Elastase-DNA and HMGB1-DNA complexes and ALN. A separate LN cohort was then used to determine the utility of NET complexes to predict renal outcomes over the subsequent 24 months. All patients had ALN, defined as a 24-hour urine protein >500mg with a subsequent modification in therapy by the treating physician, a baseline eGFR >30ml/min (3 months prior to the flare), stored serum sample ±3 months from the renal flare, and at least 2- years follow-up. The following outcomes were ascertained: Complete response (CR) at 12 and 24 months after flare (proteinuria <500mg/day and a serum creatinine within 15% of the baseline); severe renal impairment (eGFR≤30ml/min) at 12 and 24 months after flare; and the percentage decline in the eGFR over the 24 months after flare. <h3>Results</h3> Ninety-two individuals were included in the exploratory cohort (49 active SLE, 23 inactive SLE and 20 HC). NET complexes were significantly higher in SLE patients compared to HC and tended to be higher in active SLE compared to inactive patients. Patients with ALN (36.7%) had significantly higher levels of NET complexes compared to active SLE without LN. Furthermore, patients with proliferative LN had higher levels of NET complexes compared to non-proliferative LN (figure 1). The LN cohort included 109 ALN patients. The median (IQR) age was 29 (23-41) years, 84% were women, and disease duration was 6.4 (0.8-10.5) years. 37.9% were Caucasian, 22.2% Black and 17.5% Asian, the baseline eGFR was 112 (97-127) ml/min. 77.9% had a kidney biopsy at the time of the LN flare, of whom 55.9% had a proliferative or mixed class, 17.4% class V, and 4.5% class I or II. 39.4% and 50.5% of the ALN patients achieved CR at 12 and 24 months, respectively and 11% had an eGFR ≤ 30ml/min after 24 months. Similar to the results from the exploratory cohort, proliferative LN had higher levels of NET complexes compared to non-proliferative LN patients (Elastase-DNA: 111.7 vs 25.9, p=0.0003; HMGB1-DNA: 85.2 vs 25.4, p=0.002, proliferative vs non-proliferative, respectively). Patients with higher baseline levels of NET complexes had higher odds of not achieving CR and of having severe renal impairment after 24 months of the flare. NET complexes outperformed conventional biomarkers (table 1). There was a linear relationship between the amount of baseline Elastase-DNA and HMGB1-DNA complexes and the decline in renal function in the subsequent 24 months (figure 2). <h3>Conclusions</h3> Elastase-DNA and HMGB1-DNA complexes predicted renal outcomes, including response to therapy and decline in kidney function at 2 years after the LN flare." @default.
• W4313532980 created "2023-01-06" @default.
• W4313532980 creator A5002819865 @default.
• W4313532980 creator A5003819915 @default.
• W4313532980 creator A5011252269 @default.
• W4313532980 creator A5018656593 @default.
• W4313532980 creator A5037716667 @default.
• W4313532980 creator A5042287861 @default.
• W4313532980 creator A5049489990 @default.
• W4313532980 date "2022-12-01" @default.
• W4313532980 modified "2023-10-18" @default.
• W4313532980 title "1117 Neutrophil extracellular traps as a biomarker to predict outcomes in lupus nephritis" @default.
• W4313532980 doi "https://doi.org/10.1136/lupus-2022-lupus21century.82" @default.
• W4313532980 hasPublicationYear "2022" @default.
• W4313532980 type Work @default.
• W4313532980 citedByCount "0" @default.
• W4313532980 crossrefType "proceedings-article" @default.
• W4313532980 hasAuthorship W4313532980A5002819865 @default.
• W4313532980 hasAuthorship W4313532980A5003819915 @default.
• W4313532980 hasAuthorship W4313532980A5011252269 @default.
• W4313532980 hasAuthorship W4313532980A5018656593 @default.
• W4313532980 hasAuthorship W4313532980A5037716667 @default.
• W4313532980 hasAuthorship W4313532980A5042287861 @default.
• W4313532980 hasAuthorship W4313532980A5049489990 @default.
• W4313532980 hasBestOaLocation W43135329801 @default.
• W4313532980 hasConcept C121332964 @default.
• W4313532980 hasConcept C126322002 @default.
• W4313532980 hasConcept C134018914 @default.
• W4313532980 hasConcept C134897094 @default.
• W4313532980 hasConcept C170493617 @default.
• W4313532980 hasConcept C181199279 @default.
• W4313532980 hasConcept C203014093 @default.
• W4313532980 hasConcept C2776317360 @default.
• W4313532980 hasConcept C2776912625 @default.
• W4313532980 hasConcept C2776914184 @default.
• W4313532980 hasConcept C2779134260 @default.
• W4313532980 hasConcept C2779561371 @default.
• W4313532980 hasConcept C2779588948 @default.
• W4313532980 hasConcept C2779912601 @default.
• W4313532980 hasConcept C2780026642 @default.
• W4313532980 hasConcept C2780091579 @default.
• W4313532980 hasConcept C2780306776 @default.
• W4313532980 hasConcept C2780327821 @default.
• W4313532980 hasConcept C2780545709 @default.
• W4313532980 hasConcept C2781044401 @default.
• W4313532980 hasConcept C2781184683 @default.
• W4313532980 hasConcept C2781197716 @default.
• W4313532980 hasConcept C44870925 @default.
• W4313532980 hasConcept C55493867 @default.
• W4313532980 hasConcept C555293320 @default.
• W4313532980 hasConcept C71924100 @default.
• W4313532980 hasConcept C72563966 @default.
• W4313532980 hasConcept C86803240 @default.
• W4313532980 hasConcept C90924648 @default.
• W4313532980 hasConceptScore W4313532980C121332964 @default.
• W4313532980 hasConceptScore W4313532980C126322002 @default.
• W4313532980 hasConceptScore W4313532980C134018914 @default.
• W4313532980 hasConceptScore W4313532980C134897094 @default.
• W4313532980 hasConceptScore W4313532980C170493617 @default.
• W4313532980 hasConceptScore W4313532980C181199279 @default.
• W4313532980 hasConceptScore W4313532980C203014093 @default.
• W4313532980 hasConceptScore W4313532980C2776317360 @default.
• W4313532980 hasConceptScore W4313532980C2776912625 @default.
• W4313532980 hasConceptScore W4313532980C2776914184 @default.
• W4313532980 hasConceptScore W4313532980C2779134260 @default.
• W4313532980 hasConceptScore W4313532980C2779561371 @default.
• W4313532980 hasConceptScore W4313532980C2779588948 @default.
• W4313532980 hasConceptScore W4313532980C2779912601 @default.
• W4313532980 hasConceptScore W4313532980C2780026642 @default.
• W4313532980 hasConceptScore W4313532980C2780091579 @default.
• W4313532980 hasConceptScore W4313532980C2780306776 @default.
• W4313532980 hasConceptScore W4313532980C2780327821 @default.
• W4313532980 hasConceptScore W4313532980C2780545709 @default.
• W4313532980 hasConceptScore W4313532980C2781044401 @default.
• W4313532980 hasConceptScore W4313532980C2781184683 @default.
• W4313532980 hasConceptScore W4313532980C2781197716 @default.
• W4313532980 hasConceptScore W4313532980C44870925 @default.
• W4313532980 hasConceptScore W4313532980C55493867 @default.
• W4313532980 hasConceptScore W4313532980C555293320 @default.
• W4313532980 hasConceptScore W4313532980C71924100 @default.
• W4313532980 hasConceptScore W4313532980C72563966 @default.
• W4313532980 hasConceptScore W4313532980C86803240 @default.
• W4313532980 hasConceptScore W4313532980C90924648 @default.
• W4313532980 hasLocation W43135329801 @default.
• W4313532980 hasOpenAccess W4313532980 @default.
• W4313532980 hasPrimaryLocation W43135329801 @default.
• W4313532980 hasRelatedWork W1981841231 @default.
• W4313532980 hasRelatedWork W2137441841 @default.
• W4313532980 hasRelatedWork W2350791026 @default.
• W4313532980 hasRelatedWork W2756281230 @default.
• W4313532980 hasRelatedWork W2890406869 @default.
• W4313532980 hasRelatedWork W2991012387 @default.
• W4313532980 hasRelatedWork W3014780274 @default.
• W4313532980 hasRelatedWork W3154282012 @default.
• W4313532980 hasRelatedWork W4313532980 @default.
• W4313532980 hasRelatedWork W4380626128 @default.
• W4313532980 isParatext "false" @default.
• W4313532980 isRetracted "false" @default.
• W4313532980 workType "article" @default.