FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313537568> ?p ?o ?g. }

• W4313537568 endingPage "100188" @default.
• W4313537568 startingPage "100188" @default.
• W4313537568 abstract "Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of care treatment, Obeticholic Acid (OCA) has been approved as second-line therapy for those non responder or intolerant to UDCA. However, due to moderate rate of UDCA-non responders and to warnings recently issued against OCA use in patients with cirrhosis, further therapies are needed.Areas covered. Deep investigations into the pathogenesis of PBC is leading to proposal of new therapeutic agents, among which peroxisome proliferator-activated receptor (PPAR) ligands seem to be highly promising given the preliminary, positive results in Phase 2 and 3 trials. Bezafibrate, the most evaluated, is currently used in clinical practice in combination with UDCA in referral centers. We herein describe completed and ongoing trials involving PPAR agonists use in PBC, analyzing pits and falls.Testing new therapeutic opportunities in PBC is challenging due to its low prevalence and slow progression. However, new drugs including PPAR agonists, are currently under investigation and should be considered for at-risk PBC patients." @default.
• W4313537568 created "2023-01-06" @default.
• W4313537568 creator A5017347634 @default.
• W4313537568 creator A5020774708 @default.
• W4313537568 creator A5052731848 @default.
• W4313537568 date "2023-01-01" @default.
• W4313537568 modified "2023-10-01" @default.
• W4313537568 title "PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales" @default.
• W4313537568 cites W1505378774 @default.
• W4313537568 cites W1527121125 @default.
• W4313537568 cites W1539564928 @default.
• W4313537568 cites W1559882044 @default.
• W4313537568 cites W1726014254 @default.
• W4313537568 cites W1966064283 @default.
• W4313537568 cites W1972779452 @default.
• W4313537568 cites W1974694649 @default.
• W4313537568 cites W1977666051 @default.
• W4313537568 cites W1980934374 @default.
• W4313537568 cites W1986688127 @default.
• W4313537568 cites W1987523828 @default.
• W4313537568 cites W1995419534 @default.
• W4313537568 cites W1998675312 @default.
• W4313537568 cites W2013860436 @default.
• W4313537568 cites W2017671227 @default.
• W4313537568 cites W2021998283 @default.
• W4313537568 cites W2033362089 @default.
• W4313537568 cites W2051242539 @default.
• W4313537568 cites W2052516365 @default.
• W4313537568 cites W2066092624 @default.
• W4313537568 cites W2071394537 @default.
• W4313537568 cites W2072362233 @default.
• W4313537568 cites W2079146831 @default.
• W4313537568 cites W2079345345 @default.
• W4313537568 cites W2086263816 @default.
• W4313537568 cites W2087798721 @default.
• W4313537568 cites W2092700213 @default.
• W4313537568 cites W2100106197 @default.
• W4313537568 cites W2108087274 @default.
• W4313537568 cites W2135800699 @default.
• W4313537568 cites W2150242486 @default.
• W4313537568 cites W2161458396 @default.
• W4313537568 cites W2170684362 @default.
• W4313537568 cites W2253420963 @default.
• W4313537568 cites W2260924587 @default.
• W4313537568 cites W2274920295 @default.
• W4313537568 cites W2411629630 @default.
• W4313537568 cites W2481743145 @default.
• W4313537568 cites W2518389324 @default.
• W4313537568 cites W2602059628 @default.
• W4313537568 cites W2605729742 @default.
• W4313537568 cites W2749610744 @default.
• W4313537568 cites W2753306570 @default.
• W4313537568 cites W2807617765 @default.
• W4313537568 cites W2922727372 @default.
• W4313537568 cites W2935507103 @default.
• W4313537568 cites W2936012150 @default.
• W4313537568 cites W2968908454 @default.
• W4313537568 cites W3010649284 @default.
• W4313537568 cites W3011514631 @default.
• W4313537568 cites W3090328678 @default.
• W4313537568 cites W3097914939 @default.
• W4313537568 cites W3125174675 @default.
• W4313537568 cites W3136061237 @default.
• W4313537568 cites W3137256548 @default.
• W4313537568 cites W3154020224 @default.
• W4313537568 cites W3174888168 @default.
• W4313537568 cites W3193674176 @default.
• W4313537568 cites W3196148322 @default.
• W4313537568 cites W3196850442 @default.
• W4313537568 cites W4242009453 @default.
• W4313537568 cites W4291708356 @default.
• W4313537568 doi "https://doi.org/10.1016/j.jtauto.2023.100188" @default.
• W4313537568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36684809" @default.
• W4313537568 hasPublicationYear "2023" @default.
• W4313537568 type Work @default.
• W4313537568 citedByCount "4" @default.
• W4313537568 countsByYear W43135375682023 @default.
• W4313537568 crossrefType "journal-article" @default.
• W4313537568 hasAuthorship W4313537568A5017347634 @default.
• W4313537568 hasAuthorship W4313537568A5020774708 @default.
• W4313537568 hasAuthorship W4313537568A5052731848 @default.
• W4313537568 hasBestOaLocation W43135375681 @default.
• W4313537568 hasConcept C126322002 @default.
• W4313537568 hasConcept C170493617 @default.
• W4313537568 hasConcept C2776362216 @default.
• W4313537568 hasConcept C2777067796 @default.
• W4313537568 hasConcept C2778938600 @default.
• W4313537568 hasConcept C2779075594 @default.
• W4313537568 hasConcept C2779134260 @default.
• W4313537568 hasConcept C2779777945 @default.
• W4313537568 hasConcept C2780366471 @default.
• W4313537568 hasConcept C2780788601 @default.
• W4313537568 hasConcept C2780965833 @default.
• W4313537568 hasConcept C2994419564 @default.
• W4313537568 hasConcept C71924100 @default.
• W4313537568 hasConcept C90924648 @default.
• W4313537568 hasConceptScore W4313537568C126322002 @default.
• W4313537568 hasConceptScore W4313537568C170493617 @default.

• next