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• W4313539988 abstract "<b><i>Introduction:</i></b> Data regarding inactivated vaccines for SARS-CoV-2 in patients undergoing maintenance hemodialysis (MHD) are limited. We aimed to investigate humoral responses induced by CoronaVac compared to BNT162b2 in this population. <b><i>Methods:</i></b> In this multicenter prospective cohort study, adult patients undergoing MHD who lacked a history of COVID-19 and decided to get vaccinated with BNT162b2 or CoronaVac were enrolled. Participants provided serum samples before, 1 and 3 months after 2 doses. Anti-SARS-CoV-2 IgG antibodies against receptor-binding domain of the virus were measured, and levels ≥50 AU/mL were considered as positive. Breakthrough infections and adverse events were recorded. <b><i>Results:</i></b> Ninety-two patients were included, 68 (73.9%) of whom were seronegative at baseline. BNT162b2 and CoronaVac were administered in 38 (55.9%) and 30 (44.1%) patients. At 1 month, seropositivity was 93.1% in BNT162b2 and 88% in CoronaVac groups (<i>p</i> = 0.519). Quantitative antibody levels were significantly higher in BNT162b2 (<i>p</i> &#x3c; 0.001). At 3 months, both seropositivity (96.4% and 78.3%, <i>p</i> = 0.045) and antibody levels (<i>p</i> = 0.001) remained higher in BNT162b2 compared to CoronaVac. Five patients (7.4%) experienced breakthrough COVID-19. Adverse events were more frequent with BNT162b2, although all of them were mild. Multiple linear regression model showed that only vaccine choice (BNT162b2) was related to the humoral response (β = 0.272, <i>p</i> = 0.038). Seropositive patients at baseline (<i>n</i> = 24) had higher antibody levels at any time point. <b><i>Conclusions:</i></b> BNT162b2 and CoronaVac induced humoral responses in naïve patients undergoing MHD, which were more robust and durable for 3 months after BNT162b2. Both vaccines created high antibody levels in patients who were seropositive at baseline." @default.
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• W4313539988 date "2023-01-01" @default.
• W4313539988 modified "2023-10-15" @default.
• W4313539988 title "Humoral Response to BNT162b2 and CoronaVac in Patients Undergoing Maintenance Hemodialysis: A Multicenter Prospective Cohort Study" @default.
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• W4313539988 doi "https://doi.org/10.1159/000528170" @default.
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