FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313540014> ?p ?o ?g. }

• W4313540014 endingPage "152098" @default.
• W4313540014 startingPage "152098" @default.
• W4313540014 abstract "Lichen sclerosus (LS) is a cutaneous disease of unknown etiology that often involves the vulva or foreskin but also can affect extragenital sites. Regardless of the anatomic site, the histomorphology and presumably pathogenesis are similar. Perhaps a clue to the pathophysiology of LS lies in its frequent association with morphea, specifically, when occurring in an extragenital context. In our experience a striking feature evident in established lichen sclerosis (LS) is one of superficial vascular drop out whereby residual vessels exhibited endothelial cell necrosis and microvascular basement membrane zone thickening, the latter reflective of antecedent episodes of microvascular injury. We sought to understand the pathophysiology that underlies the distinct vascular changes and in doing so, shed light on the pathogenesis of LS. We examined 44 cases of LS over a period of 2019 to 2021. We were able to obtain past medical histories in 34 of the 44 cases. Regarding pathological assessment, the predominant focus was on microvascular changes. We assessed the role of C5b-9 mediated vascular injury in the pathogenesis of the vasculopathy and enhanced type I interferon signaling in vessels given the morphologic semblance to the select interferonopathy syndromes, namely fibrosing dermatomyositis and Kohlmeier Degos disease. We examined the expression of CMV DNA and protein based on prior observations in an earlier study that isolated early protein expression in the microvasculature in the setting of LS and scleroderma. From a clinical perspective, the most striking association was an older age at the time of diagnosis (mean age of 62 years and median age of 61.5 years) and the presence of vascular comorbidities of diabetes, hypertension, and hyperlipidemia in almost 80% of cases. All cases showed significant microvascular changes in the superficial corium with the most frequent findings being those of significant basement membrane zone reduplication and vascular drop out. A number of cases showed prominent microvascular deposits of C5b-9 in the zone of hyalinizing fibrosis or subjacent to the discernible table of fibroplasia in the absence of enhanced type I interferon signaling. In no case were there viral cytopathic changes associated with CMV affecting the endothelium. The studies that encode CMV DNA or protein did not show a significant role for CMV reactivation in endothelium in the majority of the studied cases. It is concluded that the pathophysiology of LS includes a microvascular injury syndrome within the papillary dermis. The mechanism of endothelial cell injury is complement mediated at least in part and could reflect an adaptive immune response targeting endothelium indicative of classic complement pathway activation when coexisting with morphea or occurring in younger individuals. A non-immune based endothelial dysfunction and complement mediated injury unrelated to antibody driven classic complement pathway activation are more likely pathogenetically in the setting of certain diseases like diabetes mellitus and hypertension. Vascular drop out can be explained by the diminished endothelial progenitor pool needed to repopulate the damaged microvessels in certain settings like hypertension and diabetes." @default.
• W4313540014 created "2023-01-06" @default.
• W4313540014 creator A5002934678 @default.
• W4313540014 creator A5012061377 @default.
• W4313540014 creator A5029494596 @default.
• W4313540014 creator A5064411755 @default.
• W4313540014 creator A5081369976 @default.
• W4313540014 date "2023-04-01" @default.
• W4313540014 modified "2023-09-27" @default.
• W4313540014 title "Lichen sclerosus: A C5B-9 mediated chronic microvascular injury syndrome potentially reflective of common adult comorbidities" @default.
• W4313540014 cites W1969388970 @default.
• W4313540014 cites W1975283514 @default.
• W4313540014 cites W1978420132 @default.
• W4313540014 cites W1981990367 @default.
• W4313540014 cites W1982975874 @default.
• W4313540014 cites W1984518805 @default.
• W4313540014 cites W2025990089 @default.
• W4313540014 cites W2034692723 @default.
• W4313540014 cites W2039561599 @default.
• W4313540014 cites W2046725122 @default.
• W4313540014 cites W2052805448 @default.
• W4313540014 cites W2057331360 @default.
• W4313540014 cites W2060259410 @default.
• W4313540014 cites W2065286950 @default.
• W4313540014 cites W2077715301 @default.
• W4313540014 cites W2078167067 @default.
• W4313540014 cites W2079869831 @default.
• W4313540014 cites W2092750118 @default.
• W4313540014 cites W2110226181 @default.
• W4313540014 cites W2112136793 @default.
• W4313540014 cites W2162326131 @default.
• W4313540014 cites W2167724179 @default.
• W4313540014 cites W2332476408 @default.
• W4313540014 cites W2398172906 @default.
• W4313540014 cites W2516947197 @default.
• W4313540014 cites W2594039164 @default.
• W4313540014 cites W2739083630 @default.
• W4313540014 cites W2907146340 @default.
• W4313540014 cites W2924427905 @default.
• W4313540014 cites W3048237569 @default.
• W4313540014 cites W4224295976 @default.
• W4313540014 cites W4286828930 @default.
• W4313540014 cites W4288063462 @default.
• W4313540014 doi "https://doi.org/10.1016/j.anndiagpath.2022.152098" @default.
• W4313540014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610314" @default.
• W4313540014 hasPublicationYear "2023" @default.
• W4313540014 type Work @default.
• W4313540014 citedByCount "1" @default.
• W4313540014 countsByYear W43135400142023 @default.
• W4313540014 crossrefType "journal-article" @default.
• W4313540014 hasAuthorship W4313540014A5002934678 @default.
• W4313540014 hasAuthorship W4313540014A5012061377 @default.
• W4313540014 hasAuthorship W4313540014A5029494596 @default.
• W4313540014 hasAuthorship W4313540014A5064411755 @default.
• W4313540014 hasAuthorship W4313540014A5081369976 @default.
• W4313540014 hasConcept C10162356 @default.
• W4313540014 hasConcept C137627325 @default.
• W4313540014 hasConcept C142724271 @default.
• W4313540014 hasConcept C151730666 @default.
• W4313540014 hasConcept C207886595 @default.
• W4313540014 hasConcept C2776552008 @default.
• W4313540014 hasConcept C2778751314 @default.
• W4313540014 hasConcept C2779134260 @default.
• W4313540014 hasConcept C2779343474 @default.
• W4313540014 hasConcept C2780942790 @default.
• W4313540014 hasConcept C71924100 @default.
• W4313540014 hasConcept C86803240 @default.
• W4313540014 hasConceptScore W4313540014C10162356 @default.
• W4313540014 hasConceptScore W4313540014C137627325 @default.
• W4313540014 hasConceptScore W4313540014C142724271 @default.
• W4313540014 hasConceptScore W4313540014C151730666 @default.
• W4313540014 hasConceptScore W4313540014C207886595 @default.
• W4313540014 hasConceptScore W4313540014C2776552008 @default.
• W4313540014 hasConceptScore W4313540014C2778751314 @default.
• W4313540014 hasConceptScore W4313540014C2779134260 @default.
• W4313540014 hasConceptScore W4313540014C2779343474 @default.
• W4313540014 hasConceptScore W4313540014C2780942790 @default.
• W4313540014 hasConceptScore W4313540014C71924100 @default.
• W4313540014 hasConceptScore W4313540014C86803240 @default.
• W4313540014 hasLocation W43135400141 @default.
• W4313540014 hasLocation W43135400142 @default.
• W4313540014 hasOpenAccess W4313540014 @default.
• W4313540014 hasPrimaryLocation W43135400141 @default.
• W4313540014 hasRelatedWork W1976892978 @default.
• W4313540014 hasRelatedWork W2341787808 @default.
• W4313540014 hasRelatedWork W2373864009 @default.
• W4313540014 hasRelatedWork W2412724149 @default.
• W4313540014 hasRelatedWork W2417694848 @default.
• W4313540014 hasRelatedWork W2437666365 @default.
• W4313540014 hasRelatedWork W2463801737 @default.
• W4313540014 hasRelatedWork W3029921958 @default.
• W4313540014 hasRelatedWork W3031163840 @default.
• W4313540014 hasRelatedWork W3047967522 @default.
• W4313540014 hasVolume "63" @default.
• W4313540014 isParatext "false" @default.
• W4313540014 isRetracted "false" @default.
• W4313540014 workType "article" @default.