Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313543311> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4313543311 endingPage "198" @default.
- W4313543311 startingPage "196" @default.
- W4313543311 abstract "Azathioprine (AZA) drug hypersensitivity reaction (DHR) is an uncommon yet potentially lethal condition that often goes unrecognised in patients with anti-Neutrophil Cytoplasmic Antibody (ANCA) associated vasculitis (AAV). We conducted a retrospective review of AAV patients on AZA maintenance therapy (N = 35). Participants were categorised into those who had experienced AZA-DHR (N = 15) and those who were AZA-tolerant (N = 20). Human leukocyte antigen (HLA) typing was performed in both groups. The primary endpoint was identification of a HLA gene association with AZA-DHR in the context of AAV. HLA-C*06:02, was solely expressed in AZA-DHR patients (33.3 %), whilst no patient who tolerated AZA carried this allele (0.0 %). This yielded a positive predictive value of 100 % for HLA-C*06:02 in predicting AZA-DHR in AAV patients, negative predictive value of 66.7 %, sensitivity of 33.3 % and specificity of 100 %. HLA-C*06:02 may predict the development of AZA-DHR in patients with AAV and inform safer therapeutic choice." @default.
- W4313543311 created "2023-01-06" @default.
- W4313543311 creator A5012861707 @default.
- W4313543311 creator A5020141588 @default.
- W4313543311 creator A5064462470 @default.
- W4313543311 creator A5079594258 @default.
- W4313543311 creator A5084767969 @default.
- W4313543311 date "2023-03-01" @default.
- W4313543311 modified "2023-09-26" @default.
- W4313543311 title "Human leukocyte antigen association with azathioprine-induced drug hypersensitivity reactions in patients with anti-neutrophil cytoplasmic antibody associated vasculitis" @default.
- W4313543311 cites W1924004664 @default.
- W4313543311 cites W1969879564 @default.
- W4313543311 cites W1970844378 @default.
- W4313543311 cites W1979398789 @default.
- W4313543311 cites W2010993971 @default.
- W4313543311 cites W2016875793 @default.
- W4313543311 cites W2044307655 @default.
- W4313543311 cites W2074435026 @default.
- W4313543311 cites W2149633671 @default.
- W4313543311 cites W2524865630 @default.
- W4313543311 cites W2561392731 @default.
- W4313543311 cites W2612782028 @default.
- W4313543311 cites W2695787953 @default.
- W4313543311 cites W2766276187 @default.
- W4313543311 cites W2769985603 @default.
- W4313543311 cites W2898232461 @default.
- W4313543311 cites W3088337877 @default.
- W4313543311 doi "https://doi.org/10.1016/j.humimm.2022.12.006" @default.
- W4313543311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610806" @default.
- W4313543311 hasPublicationYear "2023" @default.
- W4313543311 type Work @default.
- W4313543311 citedByCount "1" @default.
- W4313543311 countsByYear W43135433112023 @default.
- W4313543311 crossrefType "journal-article" @default.
- W4313543311 hasAuthorship W4313543311A5012861707 @default.
- W4313543311 hasAuthorship W4313543311A5020141588 @default.
- W4313543311 hasAuthorship W4313543311A5064462470 @default.
- W4313543311 hasAuthorship W4313543311A5079594258 @default.
- W4313543311 hasAuthorship W4313543311A5084767969 @default.
- W4313543311 hasConcept C126322002 @default.
- W4313543311 hasConcept C147483822 @default.
- W4313543311 hasConcept C151730666 @default.
- W4313543311 hasConcept C159654299 @default.
- W4313543311 hasConcept C188280979 @default.
- W4313543311 hasConcept C203014093 @default.
- W4313543311 hasConcept C2776015282 @default.
- W4313543311 hasConcept C2776760755 @default.
- W4313543311 hasConcept C2779134260 @default.
- W4313543311 hasConcept C2779343474 @default.
- W4313543311 hasConcept C71924100 @default.
- W4313543311 hasConcept C86803240 @default.
- W4313543311 hasConceptScore W4313543311C126322002 @default.
- W4313543311 hasConceptScore W4313543311C147483822 @default.
- W4313543311 hasConceptScore W4313543311C151730666 @default.
- W4313543311 hasConceptScore W4313543311C159654299 @default.
- W4313543311 hasConceptScore W4313543311C188280979 @default.
- W4313543311 hasConceptScore W4313543311C203014093 @default.
- W4313543311 hasConceptScore W4313543311C2776015282 @default.
- W4313543311 hasConceptScore W4313543311C2776760755 @default.
- W4313543311 hasConceptScore W4313543311C2779134260 @default.
- W4313543311 hasConceptScore W4313543311C2779343474 @default.
- W4313543311 hasConceptScore W4313543311C71924100 @default.
- W4313543311 hasConceptScore W4313543311C86803240 @default.
- W4313543311 hasIssue "3" @default.
- W4313543311 hasLocation W43135433111 @default.
- W4313543311 hasLocation W43135433112 @default.
- W4313543311 hasOpenAccess W4313543311 @default.
- W4313543311 hasPrimaryLocation W43135433111 @default.
- W4313543311 hasRelatedWork W1972624436 @default.
- W4313543311 hasRelatedWork W2008949385 @default.
- W4313543311 hasRelatedWork W2031391748 @default.
- W4313543311 hasRelatedWork W2040191638 @default.
- W4313543311 hasRelatedWork W2050258937 @default.
- W4313543311 hasRelatedWork W2093207255 @default.
- W4313543311 hasRelatedWork W2324237330 @default.
- W4313543311 hasRelatedWork W2330878686 @default.
- W4313543311 hasRelatedWork W33508033 @default.
- W4313543311 hasRelatedWork W940191291 @default.
- W4313543311 hasVolume "84" @default.
- W4313543311 isParatext "false" @default.
- W4313543311 isRetracted "false" @default.
- W4313543311 workType "article" @default.