Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313543634> ?p ?o ?g. }
- W4313543634 abstract "Abstract Theca cells serve multiple essential functions during the growth and maturation of ovarian follicles, providing structural, metabolic, and steroidogenic support. While the function of theca during folliculogenesis is well established, their cellular origins and the differentiation hierarchy that generates distinct theca sub-types, remain unknown. Here, we performed single cell multi-omics analysis of primary cell populations purified from human antral stage follicles (1–3 mm) to define the differentiation trajectory of theca/stroma cells. We then corroborated the temporal emergence and growth kinetics of defined theca/stroma subpopulations using human ovarian tissue samples and xenografts of cryopreserved/thawed ovarian cortex, respectively. We identified three lineage specific derivatives termed structural, androgenic, and perifollicular theca cells, as well as their putative lineage-negative progenitor. These findings provide a framework for understanding the differentiation process that occurs in each primordial follicle and identifies specific cellular/molecular phenotypes that may be relevant to either diagnosis or treatment of ovarian pathologies." @default.
- W4313543634 created "2023-01-06" @default.
- W4313543634 creator A5002697200 @default.
- W4313543634 creator A5003184805 @default.
- W4313543634 creator A5007325379 @default.
- W4313543634 creator A5007401676 @default.
- W4313543634 creator A5009762567 @default.
- W4313543634 creator A5010659244 @default.
- W4313543634 creator A5014199157 @default.
- W4313543634 creator A5036543946 @default.
- W4313543634 creator A5039441237 @default.
- W4313543634 creator A5040544082 @default.
- W4313543634 creator A5042184982 @default.
- W4313543634 creator A5047910973 @default.
- W4313543634 creator A5049660378 @default.
- W4313543634 creator A5053473307 @default.
- W4313543634 creator A5056411245 @default.
- W4313543634 creator A5068488470 @default.
- W4313543634 date "2023-01-04" @default.
- W4313543634 modified "2023-10-14" @default.
- W4313543634 title "Human theca arises from ovarian stroma and is comprised of three discrete subtypes" @default.
- W4313543634 cites W1541114935 @default.
- W4313543634 cites W1977873240 @default.
- W4313543634 cites W1986290968 @default.
- W4313543634 cites W1987383242 @default.
- W4313543634 cites W1989178868 @default.
- W4313543634 cites W1993415261 @default.
- W4313543634 cites W2001244523 @default.
- W4313543634 cites W2004379308 @default.
- W4313543634 cites W2008008410 @default.
- W4313543634 cites W2008576409 @default.
- W4313543634 cites W2015478664 @default.
- W4313543634 cites W2017120435 @default.
- W4313543634 cites W2027698896 @default.
- W4313543634 cites W2030055950 @default.
- W4313543634 cites W2049341058 @default.
- W4313543634 cites W2051624773 @default.
- W4313543634 cites W2055911575 @default.
- W4313543634 cites W2058173429 @default.
- W4313543634 cites W2060004978 @default.
- W4313543634 cites W2060286622 @default.
- W4313543634 cites W2065410333 @default.
- W4313543634 cites W2071002924 @default.
- W4313543634 cites W2077226203 @default.
- W4313543634 cites W2101256881 @default.
- W4313543634 cites W2107148164 @default.
- W4313543634 cites W2118717572 @default.
- W4313543634 cites W2120657538 @default.
- W4313543634 cites W2128017454 @default.
- W4313543634 cites W2131450997 @default.
- W4313543634 cites W2134989837 @default.
- W4313543634 cites W2137244527 @default.
- W4313543634 cites W2142562581 @default.
- W4313543634 cites W2144436656 @default.
- W4313543634 cites W2151153435 @default.
- W4313543634 cites W2160715802 @default.
- W4313543634 cites W2169717724 @default.
- W4313543634 cites W2173591627 @default.
- W4313543634 cites W2204191294 @default.
- W4313543634 cites W2228991651 @default.
- W4313543634 cites W2528009933 @default.
- W4313543634 cites W2594227676 @default.
- W4313543634 cites W2743328005 @default.
- W4313543634 cites W2763710570 @default.
- W4313543634 cites W2784289256 @default.
- W4313543634 cites W2804273359 @default.
- W4313543634 cites W2888474749 @default.
- W4313543634 cites W2899224630 @default.
- W4313543634 cites W2913703199 @default.
- W4313543634 cites W2929553976 @default.
- W4313543634 cites W2943986844 @default.
- W4313543634 cites W2949177718 @default.
- W4313543634 cites W2958681976 @default.
- W4313543634 cites W3010260031 @default.
- W4313543634 cites W3035746192 @default.
- W4313543634 cites W3048469074 @default.
- W4313543634 cites W3108331675 @default.
- W4313543634 cites W3137380028 @default.
- W4313543634 cites W3175966620 @default.
- W4313543634 cites W3197902824 @default.
- W4313543634 cites W4200435432 @default.
- W4313543634 cites W4220926455 @default.
- W4313543634 cites W4300981716 @default.
- W4313543634 doi "https://doi.org/10.1038/s42003-022-04384-8" @default.
- W4313543634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36599970" @default.
- W4313543634 hasPublicationYear "2023" @default.
- W4313543634 type Work @default.
- W4313543634 citedByCount "1" @default.
- W4313543634 countsByYear W43135436342023 @default.
- W4313543634 crossrefType "journal-article" @default.
- W4313543634 hasAuthorship W4313543634A5002697200 @default.
- W4313543634 hasAuthorship W4313543634A5003184805 @default.
- W4313543634 hasAuthorship W4313543634A5007325379 @default.
- W4313543634 hasAuthorship W4313543634A5007401676 @default.
- W4313543634 hasAuthorship W4313543634A5009762567 @default.
- W4313543634 hasAuthorship W4313543634A5010659244 @default.
- W4313543634 hasAuthorship W4313543634A5014199157 @default.
- W4313543634 hasAuthorship W4313543634A5036543946 @default.
- W4313543634 hasAuthorship W4313543634A5039441237 @default.
- W4313543634 hasAuthorship W4313543634A5040544082 @default.