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• W4313543987 endingPage "e1011034" @default.
• W4313543987 startingPage "e1011034" @default.
• W4313543987 abstract "Clostridioides difficile ( C . difficile ) is an opportunistic pathogen that leads to antibiotic-associated diarrhoea and is a leading cause of morbidity and mortality worldwide. Antibiotic usage is the main risk factor leading to C . difficile infection (CDI), as a dysbiotic gut environment allows colonisation and eventual pathology manifested by toxin production. Although colonisation resistance is mediated by the action of secondary bile acids inhibiting vegetative outgrowth, nutrient competition also plays a role in preventing CDI as the gut microbiota compete for nutrient niches inhibiting C . difficile growth. C . difficile is able to metabolise carbon dioxide, the amino acids proline, hydroxyproline, and ornithine, the cell membrane constituent ethanolamine, and the carbohydrates trehalose, cellobiose, sorbitol, and mucin degradation products as carbon and energy sources through multiple pathways. Zinc sequestration by the host response mediates metabolic adaptation of C . difficile by perhaps signalling an inflamed gut allowing it to acquire abundant nutrients. Persistence within the gut environment is also mediated by the by-products of metabolism through the production of p -cresol, which inhibit gut commensal species growth promoting dysbiosis. This review aims to explore and describe the various metabolic pathways of C . difficile , which facilitate its survival and pathogenesis within the colonised host gut." @default.
• W4313543987 created "2023-01-06" @default.
• W4313543987 creator A5025963905 @default.
• W4313543987 creator A5050644971 @default.
• W4313543987 creator A5059145168 @default.
• W4313543987 creator A5064058523 @default.
• W4313543987 date "2023-01-05" @default.
• W4313543987 modified "2023-10-16" @default.
• W4313543987 title "Food for thought—The link between Clostridioides difficile metabolism and pathogenesis" @default.
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