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- W4313544434 abstract "Extracellular vesicles (EVs) are cell-derived membrane-enclosed structures that deliver biomolecules for intercellular communication. Developing visualization methods to elucidate the spatiotemporal dynamics of EVs' behaviors will facilitate their understanding and translation. With a quantum dot (QD) labeling strategy, a single particle tracking (SPT) platform is proposed here for dissecting the dynamic behaviors of EVs. The interplays between tumor cell-derived small EVs (T-sEVs) and endothelial cells (ECs) are specifically investigated based on this platform. It is revealed that, following a clathrin-mediated endocytosis by ECs, T-sEVs are transported to the perinuclear region in a typical three-stage pattern. Importantly, T-sEVs frequently interact with and finally enter lysosomes, followed by quick release of their carried miRNAs. This study, for the first time, reports the entire process and detailed dynamics of T-sEV transportation and cargo-release in ECs, leading to better understanding of their proangiogenic functions. Additionally, the QD-based SPT technique will help uncover more secrets of sEV-mediated cell-cell communication." @default.
- W4313544434 created "2023-01-06" @default.
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- W4313544434 date "2023-01-04" @default.
- W4313544434 modified "2023-10-14" @default.
- W4313544434 title "Real‐Time Dissection of the Transportation and miRNA‐Release Dynamics of Small Extracellular Vesicles" @default.
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- W4313544434 doi "https://doi.org/10.1002/advs.202205566" @default.
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