FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313545226> ?p ?o ?g. }

• W4313545226 endingPage "e004285" @default.
• W4313545226 startingPage "e004285" @default.
• W4313545226 abstract "Background Groundbreaking studies have linked the gut microbiome with immune homeostasis and antitumor immune responses. Mounting evidence has also demonstrated an intratumoral microbiome, including in soft tissue sarcomas (STS), although detailed characterization of the STS intratumoral microbiome is limited. We sought to characterize the intratumoral microbiome in patients with STS undergoing preoperative radiotherapy and surgery, hypothesizing the presence of a distinct intratumoral microbiome with potentially clinically significant microbial signatures. Methods We prospectively obtained tumor and stool samples from adult patients with non-metastatic STS using a strict sterile collection protocol to minimize contamination. Metagenomic classification was used to estimate abundance using genus and species taxonomic levels across all classified organisms, and data were analyzed with respect to clinicopathologic factors. Results Fifteen patients were enrolled. Most tumors were located at an extremity (67%) and were histologic grade 3 (87%). 40% were well-differentiated/dedifferentiated liposarcoma histology. With a median follow-up of 24 months, 4 (27%) patients developed metastases, and 3 (20%) died. Despite overwhelming human DNA (>99%) intratumorally, we detected a small but consistent proportion of bacterial DNA (0.02–0.03%) in all tumors, including Proteobacteria, Bacteroidetes, and Firmicutes , as well as viral species. In the tumor microenvironment, we observed a strong positive correlation between viral relative abundance and natural killer (NK) infiltration, and higher NK infiltration was associated with superior metastasis-free and overall survival by immunohistochemical, flow cytometry, and multiplex immunofluorescence analyses. Conclusions We prospectively demonstrate the presence of a distinct and measurable intratumoral microbiome in patients with STS at multiple time points. Our data suggest that the STS tumor microbiome has prognostic significance with viral relative abundance associated with NK infiltration and oncologic outcome. Additional studies are warranted to further assess the clinical impact of these findings." @default.
• W4313545226 created "2023-01-06" @default.
• W4313545226 creator A5012356072 @default.
• W4313545226 creator A5014555448 @default.
• W4313545226 creator A5028006340 @default.
• W4313545226 creator A5030921370 @default.
• W4313545226 creator A5042070203 @default.
• W4313545226 creator A5054618664 @default.
• W4313545226 creator A5057455952 @default.
• W4313545226 creator A5059066311 @default.
• W4313545226 creator A5062912806 @default.
• W4313545226 creator A5063210113 @default.
• W4313545226 creator A5065634805 @default.
• W4313545226 creator A5065693288 @default.
• W4313545226 creator A5069430287 @default.
• W4313545226 creator A5069743420 @default.
• W4313545226 creator A5075999686 @default.
• W4313545226 creator A5077997094 @default.
• W4313545226 creator A5085439094 @default.
• W4313545226 date "2023-01-01" @default.
• W4313545226 modified "2023-10-16" @default.
• W4313545226 title "Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis" @default.
• W4313545226 cites W1839618459 @default.
• W4313545226 cites W2007110604 @default.
• W4313545226 cites W2013224779 @default.
• W4313545226 cites W2031990795 @default.
• W4313545226 cites W2034183402 @default.
• W4313545226 cites W2049093000 @default.
• W4313545226 cites W2051890542 @default.
• W4313545226 cites W2056279562 @default.
• W4313545226 cites W2073924079 @default.
• W4313545226 cites W2081070412 @default.
• W4313545226 cites W2093575565 @default.
• W4313545226 cites W2107018762 @default.
• W4313545226 cites W2146512944 @default.
• W4313545226 cites W2169474803 @default.
• W4313545226 cites W2170486072 @default.
• W4313545226 cites W2317340981 @default.
• W4313545226 cites W2345658906 @default.
• W4313545226 cites W2580171030 @default.
• W4313545226 cites W2765314233 @default.
• W4313545226 cites W2790263617 @default.
• W4313545226 cites W2790589159 @default.
• W4313545226 cites W2791673983 @default.
• W4313545226 cites W2797443945 @default.
• W4313545226 cites W2801011555 @default.
• W4313545226 cites W2804448077 @default.
• W4313545226 cites W2903174799 @default.
• W4313545226 cites W2966235591 @default.
• W4313545226 cites W2971177181 @default.
• W4313545226 cites W2972674410 @default.
• W4313545226 cites W2990618091 @default.
• W4313545226 cites W3005933253 @default.
• W4313545226 cites W3009918166 @default.
• W4313545226 cites W3030942202 @default.
• W4313545226 cites W3035400545 @default.
• W4313545226 cites W3039664048 @default.
• W4313545226 cites W3045498347 @default.
• W4313545226 cites W3095032600 @default.
• W4313545226 cites W3101276404 @default.
• W4313545226 cites W3111836013 @default.
• W4313545226 cites W3120414804 @default.
• W4313545226 cites W3126208996 @default.
• W4313545226 cites W3131560362 @default.
• W4313545226 cites W3138215020 @default.
• W4313545226 cites W3157849933 @default.
• W4313545226 cites W4284706390 @default.
• W4313545226 doi "https://doi.org/10.1136/jitc-2021-004285" @default.
• W4313545226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36599469" @default.
• W4313545226 hasPublicationYear "2023" @default.
• W4313545226 type Work @default.
• W4313545226 citedByCount "5" @default.
• W4313545226 countsByYear W43135452262023 @default.
• W4313545226 crossrefType "journal-article" @default.
• W4313545226 hasAuthorship W4313545226A5012356072 @default.
• W4313545226 hasAuthorship W4313545226A5014555448 @default.
• W4313545226 hasAuthorship W4313545226A5028006340 @default.
• W4313545226 hasAuthorship W4313545226A5030921370 @default.
• W4313545226 hasAuthorship W4313545226A5042070203 @default.
• W4313545226 hasAuthorship W4313545226A5054618664 @default.
• W4313545226 hasAuthorship W4313545226A5057455952 @default.
• W4313545226 hasAuthorship W4313545226A5059066311 @default.
• W4313545226 hasAuthorship W4313545226A5062912806 @default.
• W4313545226 hasAuthorship W4313545226A5063210113 @default.
• W4313545226 hasAuthorship W4313545226A5065634805 @default.
• W4313545226 hasAuthorship W4313545226A5065693288 @default.
• W4313545226 hasAuthorship W4313545226A5069430287 @default.
• W4313545226 hasAuthorship W4313545226A5069743420 @default.
• W4313545226 hasAuthorship W4313545226A5075999686 @default.
• W4313545226 hasAuthorship W4313545226A5077997094 @default.
• W4313545226 hasAuthorship W4313545226A5085439094 @default.
• W4313545226 hasBestOaLocation W43135452261 @default.
• W4313545226 hasConcept C142724271 @default.
• W4313545226 hasConcept C143121216 @default.
• W4313545226 hasConcept C190944805 @default.
• W4313545226 hasConcept C203014093 @default.
• W4313545226 hasConcept C2776107976 @default.
• W4313545226 hasConcept C60644358 @default.

• next