Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313545349> ?p ?o ?g. }
- W4313545349 endingPage "538" @default.
- W4313545349 startingPage "530" @default.
- W4313545349 abstract "Resident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient in 12-lipoxygenase and 15-lipoxygenase (Alox15-/- mice) that neonatal neutrophil-derived 12-HETE is required for self-renewal and maintenance of alveolar macrophages (AMs) during lung development. Although the seeding and differentiation of AM progenitors remained intact, the absence of 12-HETE led to a significant reduction in AMs in adult lungs and enhanced senescence owing to increased prostaglandin E2 production. A compromised AM compartment resulted in increased susceptibility to acute lung injury induced by lipopolysaccharide and to pulmonary infections with influenza A virus or SARS-CoV-2. Our results highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal." @default.
- W4313545349 created "2023-01-06" @default.
- W4313545349 creator A5003124477 @default.
- W4313545349 creator A5006080048 @default.
- W4313545349 creator A5011187675 @default.
- W4313545349 creator A5011490926 @default.
- W4313545349 creator A5014692366 @default.
- W4313545349 creator A5019094411 @default.
- W4313545349 creator A5019495500 @default.
- W4313545349 creator A5019698804 @default.
- W4313545349 creator A5022260354 @default.
- W4313545349 creator A5039968012 @default.
- W4313545349 creator A5051250373 @default.
- W4313545349 creator A5051993142 @default.
- W4313545349 creator A5070127391 @default.
- W4313545349 creator A5076925912 @default.
- W4313545349 creator A5078760340 @default.
- W4313545349 creator A5081181737 @default.
- W4313545349 creator A5084646746 @default.
- W4313545349 creator A5087439719 @default.
- W4313545349 creator A5088435548 @default.
- W4313545349 creator A5088515016 @default.
- W4313545349 date "2023-01-04" @default.
- W4313545349 modified "2023-09-30" @default.
- W4313545349 title "Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE" @default.
- W4313545349 cites W1589735741 @default.
- W4313545349 cites W1600560134 @default.
- W4313545349 cites W1627618697 @default.
- W4313545349 cites W1766122222 @default.
- W4313545349 cites W1767389458 @default.
- W4313545349 cites W1774666547 @default.
- W4313545349 cites W1973433801 @default.
- W4313545349 cites W1978946907 @default.
- W4313545349 cites W1979941665 @default.
- W4313545349 cites W1981926613 @default.
- W4313545349 cites W1997396254 @default.
- W4313545349 cites W1998598404 @default.
- W4313545349 cites W2012063163 @default.
- W4313545349 cites W2034209637 @default.
- W4313545349 cites W2061600879 @default.
- W4313545349 cites W2083439589 @default.
- W4313545349 cites W2093631337 @default.
- W4313545349 cites W2100646399 @default.
- W4313545349 cites W2104058942 @default.
- W4313545349 cites W2112671019 @default.
- W4313545349 cites W2115852450 @default.
- W4313545349 cites W2120579640 @default.
- W4313545349 cites W2134526812 @default.
- W4313545349 cites W2149547303 @default.
- W4313545349 cites W2158668374 @default.
- W4313545349 cites W2171808845 @default.
- W4313545349 cites W2179438025 @default.
- W4313545349 cites W2593148326 @default.
- W4313545349 cites W2600265228 @default.
- W4313545349 cites W2607501063 @default.
- W4313545349 cites W2617627282 @default.
- W4313545349 cites W2689866037 @default.
- W4313545349 cites W2742007963 @default.
- W4313545349 cites W2767487209 @default.
- W4313545349 cites W2779515317 @default.
- W4313545349 cites W2783711120 @default.
- W4313545349 cites W2788548733 @default.
- W4313545349 cites W2896222795 @default.
- W4313545349 cites W2921168633 @default.
- W4313545349 cites W2931036699 @default.
- W4313545349 cites W2945979411 @default.
- W4313545349 cites W2951506174 @default.
- W4313545349 cites W2964849163 @default.
- W4313545349 cites W2971754877 @default.
- W4313545349 cites W2997280954 @default.
- W4313545349 cites W3044190151 @default.
- W4313545349 cites W3081244137 @default.
- W4313545349 cites W3096828292 @default.
- W4313545349 cites W3133294399 @default.
- W4313545349 cites W3157103618 @default.
- W4313545349 cites W3203496375 @default.
- W4313545349 doi "https://doi.org/10.1038/s41586-022-05660-7" @default.
- W4313545349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36599368" @default.
- W4313545349 hasPublicationYear "2023" @default.
- W4313545349 type Work @default.
- W4313545349 citedByCount "5" @default.
- W4313545349 countsByYear W43135453492023 @default.
- W4313545349 crossrefType "journal-article" @default.
- W4313545349 hasAuthorship W4313545349A5003124477 @default.
- W4313545349 hasAuthorship W4313545349A5006080048 @default.
- W4313545349 hasAuthorship W4313545349A5011187675 @default.
- W4313545349 hasAuthorship W4313545349A5011490926 @default.
- W4313545349 hasAuthorship W4313545349A5014692366 @default.
- W4313545349 hasAuthorship W4313545349A5019094411 @default.
- W4313545349 hasAuthorship W4313545349A5019495500 @default.
- W4313545349 hasAuthorship W4313545349A5019698804 @default.
- W4313545349 hasAuthorship W4313545349A5022260354 @default.
- W4313545349 hasAuthorship W4313545349A5039968012 @default.
- W4313545349 hasAuthorship W4313545349A5051250373 @default.
- W4313545349 hasAuthorship W4313545349A5051993142 @default.
- W4313545349 hasAuthorship W4313545349A5070127391 @default.
- W4313545349 hasAuthorship W4313545349A5076925912 @default.
- W4313545349 hasAuthorship W4313545349A5078760340 @default.