Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313546279> ?p ?o ?g. }
- W4313546279 endingPage "581" @default.
- W4313546279 startingPage "575" @default.
- W4313546279 abstract "Understanding how the nuclear pore complex (NPC) is assembled is of fundamental importance to grasp the mechanisms behind its essential function and understand its role during the evolution of eukaryotes1-4. There are at least two NPC assembly pathways-one during the exit from mitosis and one during nuclear growth in interphase-but we currently lack a quantitative map of these events. Here we use fluorescence correlation spectroscopy calibrated live imaging of endogenously fluorescently tagged nucleoporins to map the changes in the composition and stoichiometry of seven major modules of the human NPC during its assembly in single dividing cells. This systematic quantitative map reveals that the two assembly pathways have distinct molecular mechanisms, in which the order of addition of two large structural components, the central ring complex and nuclear filaments are inverted. The dynamic stoichiometry data was integrated to create a spatiotemporal model of the NPC assembly pathway and predict the structures of postmitotic NPC assembly intermediates." @default.
- W4313546279 created "2023-01-06" @default.
- W4313546279 creator A5008981528 @default.
- W4313546279 creator A5026534952 @default.
- W4313546279 creator A5028845140 @default.
- W4313546279 creator A5041504251 @default.
- W4313546279 creator A5043267985 @default.
- W4313546279 creator A5047751097 @default.
- W4313546279 creator A5054276688 @default.
- W4313546279 creator A5070762585 @default.
- W4313546279 creator A5082422826 @default.
- W4313546279 creator A5084538139 @default.
- W4313546279 creator A5089370296 @default.
- W4313546279 creator A5091844533 @default.
- W4313546279 date "2023-01-04" @default.
- W4313546279 modified "2023-10-18" @default.
- W4313546279 title "A quantitative map of nuclear pore assembly reveals two distinct mechanisms" @default.
- W4313546279 cites W1579964499 @default.
- W4313546279 cites W1899765255 @default.
- W4313546279 cites W1980396134 @default.
- W4313546279 cites W2002832176 @default.
- W4313546279 cites W2013576844 @default.
- W4313546279 cites W2030555694 @default.
- W4313546279 cites W2035671523 @default.
- W4313546279 cites W2045957964 @default.
- W4313546279 cites W2059291367 @default.
- W4313546279 cites W2073735624 @default.
- W4313546279 cites W2073742793 @default.
- W4313546279 cites W2079123529 @default.
- W4313546279 cites W2087616070 @default.
- W4313546279 cites W2099540110 @default.
- W4313546279 cites W2111560040 @default.
- W4313546279 cites W2121158677 @default.
- W4313546279 cites W2139759270 @default.
- W4313546279 cites W2145876651 @default.
- W4313546279 cites W2149612795 @default.
- W4313546279 cites W2165913063 @default.
- W4313546279 cites W2168648059 @default.
- W4313546279 cites W2171135008 @default.
- W4313546279 cites W2177978865 @default.
- W4313546279 cites W2220896177 @default.
- W4313546279 cites W2335825911 @default.
- W4313546279 cites W2519148913 @default.
- W4313546279 cites W2529052661 @default.
- W4313546279 cites W2767782200 @default.
- W4313546279 cites W2790485917 @default.
- W4313546279 cites W2793039150 @default.
- W4313546279 cites W2804370530 @default.
- W4313546279 cites W2890313592 @default.
- W4313546279 cites W2891496493 @default.
- W4313546279 cites W2921042206 @default.
- W4313546279 cites W2935467328 @default.
- W4313546279 cites W2947359287 @default.
- W4313546279 cites W2949721790 @default.
- W4313546279 cites W2950446586 @default.
- W4313546279 cites W2976942992 @default.
- W4313546279 cites W2998779366 @default.
- W4313546279 cites W3006640974 @default.
- W4313546279 cites W3019102719 @default.
- W4313546279 cites W3083406432 @default.
- W4313546279 cites W3112376933 @default.
- W4313546279 cites W3113218741 @default.
- W4313546279 cites W3176144469 @default.
- W4313546279 cites W4211177544 @default.
- W4313546279 cites W4281677038 @default.
- W4313546279 cites W4282936228 @default.
- W4313546279 doi "https://doi.org/10.1038/s41586-022-05528-w" @default.
- W4313546279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36599981" @default.
- W4313546279 hasPublicationYear "2023" @default.
- W4313546279 type Work @default.
- W4313546279 citedByCount "11" @default.
- W4313546279 countsByYear W43135462792023 @default.
- W4313546279 crossrefType "journal-article" @default.
- W4313546279 hasAuthorship W4313546279A5008981528 @default.
- W4313546279 hasAuthorship W4313546279A5026534952 @default.
- W4313546279 hasAuthorship W4313546279A5028845140 @default.
- W4313546279 hasAuthorship W4313546279A5041504251 @default.
- W4313546279 hasAuthorship W4313546279A5043267985 @default.
- W4313546279 hasAuthorship W4313546279A5047751097 @default.
- W4313546279 hasAuthorship W4313546279A5054276688 @default.
- W4313546279 hasAuthorship W4313546279A5070762585 @default.
- W4313546279 hasAuthorship W4313546279A5082422826 @default.
- W4313546279 hasAuthorship W4313546279A5084538139 @default.
- W4313546279 hasAuthorship W4313546279A5089370296 @default.
- W4313546279 hasAuthorship W4313546279A5091844533 @default.
- W4313546279 hasBestOaLocation W43135462791 @default.
- W4313546279 hasConcept C12554922 @default.
- W4313546279 hasConcept C126725582 @default.
- W4313546279 hasConcept C14036430 @default.
- W4313546279 hasConcept C144618238 @default.
- W4313546279 hasConcept C178790620 @default.
- W4313546279 hasConcept C185592680 @default.
- W4313546279 hasConcept C2780114586 @default.
- W4313546279 hasConcept C2780723820 @default.
- W4313546279 hasConcept C29452124 @default.
- W4313546279 hasConcept C32909587 @default.
- W4313546279 hasConcept C59157529 @default.
- W4313546279 hasConcept C68556195 @default.