Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313546553> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W4313546553 endingPage "1030" @default.
- W4313546553 startingPage "1023" @default.
- W4313546553 abstract "Mineralocorticoid receptor antagonists not only are used as a diuretics to treat essential hypertension, but also protect the heart and kidney by inhibiting inflammation and fibrosis. Since the discovery of spironolactone, the first generation of mineralocorticoid receptor antagonist, two types of non-steroid mineralocorticoid receptor antagonists (finerenone and esaxerenone) approved for clinical use have been developed, which have the advantages of high affinity, high selectivity and balanced distribution in heart and kidney, and can be used in clinic as a cardiorenal protective drug. In this paper, the development history of mineralocorticoid receptor antagonists was reviewed, and the pathophysiological mechanism of inflammation and fibrosis caused by mineralocorticoid receptors and the similarities and differences of different generations of mineralocorticoid receptor antagonists were analyzed. In particular, the phase III clinical research evidence of finerenone and esaxerenone was discussed. This paper also reviews the research progress of cardiorenal protection of non-steroid mineralocorticoid receptor antagonists in patients with chronic kidney disease." @default.
- W4313546553 created "2023-01-06" @default.
- W4313546553 creator A5008201587 @default.
- W4313546553 creator A5032526310 @default.
- W4313546553 date "2022-12-25" @default.
- W4313546553 modified "2023-10-16" @default.
- W4313546553 title "[Research progress on the cardiorenal protection of non-steroid mineralocorticoid receptor antagonists in patients with chronic kidney disease]." @default.
- W4313546553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36594390" @default.
- W4313546553 hasPublicationYear "2022" @default.
- W4313546553 type Work @default.
- W4313546553 citedByCount "0" @default.
- W4313546553 crossrefType "journal-article" @default.
- W4313546553 hasAuthorship W4313546553A5008201587 @default.
- W4313546553 hasAuthorship W4313546553A5032526310 @default.
- W4313546553 hasConcept C126322002 @default.
- W4313546553 hasConcept C134018914 @default.
- W4313546553 hasConcept C189135053 @default.
- W4313546553 hasConcept C2776069600 @default.
- W4313546553 hasConcept C2776379505 @default.
- W4313546553 hasConcept C2778525890 @default.
- W4313546553 hasConcept C2778653478 @default.
- W4313546553 hasConcept C2780072264 @default.
- W4313546553 hasConcept C71924100 @default.
- W4313546553 hasConcept C98274493 @default.
- W4313546553 hasConceptScore W4313546553C126322002 @default.
- W4313546553 hasConceptScore W4313546553C134018914 @default.
- W4313546553 hasConceptScore W4313546553C189135053 @default.
- W4313546553 hasConceptScore W4313546553C2776069600 @default.
- W4313546553 hasConceptScore W4313546553C2776379505 @default.
- W4313546553 hasConceptScore W4313546553C2778525890 @default.
- W4313546553 hasConceptScore W4313546553C2778653478 @default.
- W4313546553 hasConceptScore W4313546553C2780072264 @default.
- W4313546553 hasConceptScore W4313546553C71924100 @default.
- W4313546553 hasConceptScore W4313546553C98274493 @default.
- W4313546553 hasIssue "6" @default.
- W4313546553 hasLocation W43135465531 @default.
- W4313546553 hasOpenAccess W4313546553 @default.
- W4313546553 hasPrimaryLocation W43135465531 @default.
- W4313546553 hasRelatedWork W1971595373 @default.
- W4313546553 hasRelatedWork W2019725123 @default.
- W4313546553 hasRelatedWork W2037408526 @default.
- W4313546553 hasRelatedWork W2072829430 @default.
- W4313546553 hasRelatedWork W2079787384 @default.
- W4313546553 hasRelatedWork W2168712739 @default.
- W4313546553 hasRelatedWork W2312942238 @default.
- W4313546553 hasRelatedWork W2516746587 @default.
- W4313546553 hasRelatedWork W2589899659 @default.
- W4313546553 hasRelatedWork W2981713925 @default.
- W4313546553 hasVolume "74" @default.
- W4313546553 isParatext "false" @default.
- W4313546553 isRetracted "false" @default.
- W4313546553 workType "article" @default.